Sequence 1: | NP_001373429.1 | Gene: | MTOR / 2475 | HGNCID: | 3942 | Length: | 2549 | Species: | Homo sapiens |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | NP_001163420.1 | Gene: | Pi3K68D / 39329 | FlyBaseID: | FBgn0015278 | Length: | 1876 | Species: | Drosophila melanogaster |
Alignment Length: | 1472 | Identity: | 285/1472 - (19%) |
---|---|---|---|
Similarity: | 458/1472 - (31%) | Gaps: | 579/1472 - (39%) |
- Green bases have known domain annotations that are detailed below.
Human 1124 APEAPLP--------SRKAALETVDRLTESLDFTD-YASRIIHPIV-----------------RT 1162
Human 1163 LDQSPEL------------RSTAMDTLSSL--VFQLGKKYQIFIPMVNKVLVRHRINHQRYDVLI 1213
Human 1214 CRI----VKGYTLADEEEDPLIYQ---HRMLRSGQGDALAS--GPVETGPMKKLHVSTINLQKAW 1269
Human 1270 GAARRVSKDDWLEWL---RRLS-LELLKDS----SSPSLRSCWALAQAYNPMARDLFNAAFVSCW 1326
Human 1327 SELNEDQQDELIRSIELALTSQDIAEVT-QTLLNLAEFME------HSDKGPLPLR---DDNGIV 1381
Human 1382 --------LLGE----RAAKCRAYAKALHYKELEFQKGPTPAILESLISINNKLQQPEAAAGVLE 1434
Human 1435 YAMKHFGELEIQATWYEKLHEWEDAL------------VAYDKKMDTNKDDP-------ELMLGR 1480
Human 1481 MRCL-EALGEWGQLHQQCCEK-------------WTLVNDETQAKMARMAAAAAWGLGQWDSMEE 1531
Human 1532 Y-TCMIPRDTHDGAFYRAVLALHQDLFSLAQQCIDKARDLLDAELTAMAGESYSRAYGAMVSCHM 1595
Human 1596 LSELEEVIQYKLVPERREIIRQIWWERLQGCQRIVEDWQKILMVRSLVVSPHEDMRTWLKYASLC 1660
Human 1661 GKSGRLALAHKTLVLLLGVDPSRQLDHPLPTVHPQVTYAYMKNMWKSARKIDAFQHMQHFVQTMQ 1725
Human 1726 QQAQH-AIATEDQQHKQELHKLMARCFLKLGEWQLNLQGINE----------------STIPKVL 1773
Human 1774 QYYSAATEHDRSWYKAWHAWAVMN---FEAVLHYKHQNQARDEKKKLRHASGANITNATTAATTA 1835
Human 1836 ATATTTASTEGSNSESEAESTENSPTP-SPLQKKVTEDLSKTLLMYTVPAVQGFFRSISLSRGNN 1899
Human 1900 LQDTLRVLTLWFDYGHWPD--VNEALVEGVKAIQIDTWLQVIPQLI-------------AR---- 1945
Human 1946 --IDTPR---PLVGRLIHQLLTD----IGRYHPQALIYPLTVASKSTTTARHNAANKILKNMCEH 2001
Human 2002 SNTLVQQAMMV--SEELIRVAILWHEMWH------EGLEEASRLYFGERNVKGMFEVLEPLHAMM 2058
Human 2059 ERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKQLPQLTSLEL 2123
Human 2124 QYVSPKLLMCRDLELAVPGTYDPNQPIIRIQSIAPSLQVITSKQRPRKLTLMGSNGHEFVFLLKG 2188
Human 2189 HEDLRQDERVMQLFGLVNTL-LANDPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRD 2252
Human 2253 YREKKKILLNIEHRIMLRMAPDYDHLTLMQKVEVFEHAVNNTAGD-DLAKLLWLKSPSSEVWFDR 2316
Human 2317 RTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKFP-EKIPFRLT 2380
Human 2381 ---RMLTNAMEVTGLDGNYRI-TCHTVMEVLREHKDSVMAVL 2418 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
MTOR | NP_001373429.1 | Interaction with NBN. /evidence=ECO:0000269|PubMed:23762398 | 1..651 | ||
TEL1 | 363..2549 | CDD:227365 | 285/1472 (19%) | ||
HEAT 16 | 637..683 | ||||
HEAT repeat | 655..681 | CDD:293787 | |||
HEAT 17 | 686..724 | ||||
HEAT repeat | 691..721 | CDD:293787 | |||
HEAT 18 | 727..766 | ||||
HEAT repeat | 729..759 | CDD:293787 | |||
HEAT 19 | 769..811 | ||||
HEAT repeat | 772..805 | CDD:293787 | |||
HEAT 20 | 814..853 | ||||
HEAT repeat | 817..847 | CDD:293787 | |||
HEAT 21 | 857..893 | ||||
HEAT 22 | 894..942 | ||||
HEAT 23 | 943..988 | ||||
HEAT repeat | 955..981 | CDD:293787 | |||
HEAT 24 | 989..1027 | ||||
HEAT repeat | 993..1021 | CDD:293787 | |||
HEAT 25 | 1029..1068 | ||||
HEAT repeat | 1033..1062 | CDD:293787 | |||
HEAT 26 | 1069..1105 | ||||
HEAT repeat | 1073..1099 | CDD:293787 | |||
HEAT 27 | 1106..1144 | 9/27 (33%) | |||
HEAT repeat | 1111..1142 | CDD:293787 | 8/25 (32%) | ||
HEAT 28 | 1145..1188 | 16/74 (22%) | |||
HEAT repeat | 1154..1180 | CDD:293787 | 10/54 (19%) | ||
HEAT 29 | 1189..1225 | 10/39 (26%) | |||
HEAT 30 | 1226..1273 | 11/51 (22%) | |||
HEAT 31 | 1274..1311 | 13/44 (30%) | |||
HEAT 32 | 1312..1345 | 5/32 (16%) | |||
TPR 1 | 1346..1382 | 10/53 (19%) | |||
TPR 2 | 1383..1408 | 9/28 (32%) | |||
TPR 3 | 1409..1442 | 6/32 (19%) | |||
TPR 4 | 1443..1473 | 7/41 (17%) | |||
TPR 5 | 1474..1507 | 8/53 (15%) | |||
TPR 6 | 1508..1541 | 6/33 (18%) | |||
TPR 7 | 1542..1574 | 2/31 (6%) | |||
TPR 8 | 1575..1614 | 7/38 (18%) | |||
TPR 9 | 1615..1649 | 3/33 (9%) | |||
TPR 10 | 1650..1693 | 11/42 (26%) | |||
TPR 11 | 1694..1731 | 6/37 (16%) | |||
TPR 12 | 1732..1786 | 12/69 (17%) | |||
TPR 13 | 1787..1846 | 7/61 (11%) | |||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1812..1867 | 5/55 (9%) | |||
TPR 14 | 1898..1930 | 6/33 (18%) | |||
TPR 15 | 1931..1970 | 14/64 (22%) | |||
TPR 16 | 1971..2005 | 5/33 (15%) | |||
Sufficient for interaction with the FKBP1A/rapamycin complex. /evidence=ECO:0000250 | 2012..2144 | 22/139 (16%) | |||
Interaction with MLST8 | 2258..2296 | 3/37 (8%) | |||
Pi3K68D | NP_001163420.1 | EIN3 | <58..392 | CDD:296674 | |
PI3K_rbd | 561..669 | CDD:197540 | 33/129 (26%) | ||
C2A_PI3K_class_II | 844..1021 | CDD:175979 | 39/260 (15%) | ||
PI3Ka_II | 1038..1202 | CDD:238441 | 48/288 (17%) | ||
PI3Kc_II | 1235..1583 | CDD:270710 | 86/414 (21%) | ||
PX_PI3K_C2_68D | 1611..1721 | CDD:132794 | |||
C2B_PI3K_class_II | 1751..1871 | CDD:176027 | |||
Blue background indicates that the domain is not in the aligned region. |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 0 | 0.000 | Not matched by this tool. | |||
Domainoid | 0 | 0.000 | Not matched by this tool. | |||
eggNOG | 1 | 0.900 | - | - | E1_COG5032 | |
Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
Homologene | 0 | 0.000 | Not matched by this tool. | |||
Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
Isobase | 0 | 0.000 | Not matched by this tool. | |||
OMA | 0 | 0.000 | Not matched by this tool. | |||
OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
Panther | 0 | 0.000 | Not matched by this tool. | |||
Phylome | 1 | 0.910 | - | - | ||
RoundUp | 0 | 0.000 | Not matched by this tool. | |||
SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
TreeFam | 0 | 0.000 | Not matched by this tool. | |||
User_Submission | 0 | 0.000 | Not matched by this tool. | |||
2 | 1.810 |