DRSC/TRiP Functional Genomics Resources

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Protein Alignment MTOR and Pi3K68D

DIOPT Version :9

Sequence 1:NP_001373429.1 Gene:MTOR / 2475 HGNCID:3942 Length:2549 Species:Homo sapiens
Sequence 2:NP_001163420.1 Gene:Pi3K68D / 39329 FlyBaseID:FBgn0015278 Length:1876 Species:Drosophila melanogaster


Alignment Length:1472 Identity:285/1472 - (19%)
Similarity:458/1472 - (31%) Gaps:579/1472 - (39%)


- Green bases have known domain annotations that are detailed below.


Human  1124 APEAPLP--------SRKAALETVDRLTESLDFTD-YASRIIHPIV-----------------RT 1162
            :|..|||        |.:||: .|.|..:|...|| |.|.|...:|                 ||
  Fly   454 SPPPPLPPRNQQCYESNQAAM-PVSRPPQSSVLTDSYTSSIPANVVLDRRKTCTRLYELISDQRT 517

Human  1163 LDQSPEL------------RSTAMDTLSSL--VFQLGKKYQIFIPMVNKVLVRHRINHQRYDVLI 1213
            .|  |||            |....|..:::  |......|...:....||:|...:|..:..||.
  Fly   518 DD--PELLEFYHMVKEVRARYPHDDAPTNVGHVVAAEFNYHYMMDTSIKVIVHPALNTLQSTVLA 580

Human  1214 CRI----VKGYTLADEEEDPLIYQ---HRMLRSGQGDALAS--GPVETGPMKKLHVSTINLQKAW 1269
            ..:    ||||.:      |:.:.   ..::......||||  |.|: |.:....|..|.|    
  Fly   581 ASMGKEQVKGYGM------PVTFTCDIDSVVAQVVAQALASLEGQVK-GTVTDYAVKPIGL---- 634

Human  1270 GAARRVSKDDWLEWL---RRLS-LELLKDS----SSPSLRSCWALAQAYNPMARDLFNAAFVSCW 1326
                       ||||   .||| ||.:.:|    ....|..|.:.|.....:||           
  Fly   635 -----------LEWLAPTSRLSQLECVHNSFQLEKDVHLGLCLSTAANMQAIAR----------- 677

Human  1327 SELNEDQQDELIRSIELALTSQDIAEVT-QTLLNLAEFME------HSDKGPLPLR---DDNGIV 1381
            :|.:::...:|:.  |..|.::.:..|| ..::.|.|.:|      .|....:|.|   ..:|:|
  Fly   678 TERDDEHDADLLP--EHLLPNEVVPIVTYDNMMILIETLEMEIDKLESAADGVPGRSVVSCSGVV 740

Human  1382 --------LLGE----RAAKCRAYAKALHYKELEFQKGPTPAILESLISINNKLQQPEAAAGVLE 1434
                    |||.    ..|:|.|..|.:  .|:|.:|..|.|            ..||..:...:
  Fly   741 QAVKAICALLGSIDTMEIARCVADLKRI--CEVEQKKYSTGA------------SNPEIVSDYGD 791

Human  1435 YAMKHFGELEIQATWYEKLHEWEDAL------------VAYDKKMDTNKDDP-------ELMLGR 1480
            ||........:......|.:|..||:            ||:..|.......|       :.::..
  Fly   792 YAQVVLRPRSMLEQIKVKCNELRDAVQELVELYANVFRVAFSVKTPDYSTTPIPISCVSKPIVVC 856

Human  1481 MRCL-EALGEWGQLHQQCCEK-------------WTLVNDETQAKMARMAAAAAWGLGQWDSMEE 1531
            :.|| ..|..|.......|.:             .|..||.:.....|:..:|      |.:.::
  Fly   857 ISCLHRPLPNWKFDDYSLCVQIVYGTRLLSKPNVLTCSNDTSGGLFPRLNFSA------WLTFDQ 915

Human  1532 Y-TCMIPRDTHDGAFYRAVLALHQDLFSLAQQCIDKARDLLDAELTAMAGESYSRAYGAMVSCHM 1595
            : .|.:||:.      |....|:                   .:..|..||..:...|       
  Fly   916 HPICTLPREA------RLTFVLY-------------------GKQAASEGEPNADQNG------- 948

Human  1596 LSELEEVIQYKLVPERREIIRQIWWERLQGCQRIVEDWQKILMVRSLVVSPHEDMRTWLKYASLC 1660
                          |||::..::.|     |...:.|:::::                     :|
  Fly   949 --------------ERRQVTTELGW-----CSIQLFDFKRVM---------------------IC 973

Human  1661 GKSGRLALAHKTLVLLLGVDPSRQLDHPLPTVHPQVTYAYMKNMWKSARKIDAFQHMQHFVQTMQ 1725
            |.. .|:|.......:||..|:|.. ||.|...|.::.    .:.....:|:..:|     |.:.
  Fly   974 GPY-LLSLWPPMTDKMLGPAPARGC-HPQPDFCPVLSI----EVPPYGGRIEFPEH-----QEVP 1027

Human  1726 QQAQH-AIATEDQQHKQELHKLMARCFLKLGEWQLNLQGINE----------------STIPKVL 1773
            :.|.| ..|:.|...::||          |...:|...|..|                :.:||||
  Fly  1028 KPAPHYDFASLDANLQEEL----------LDTAELGYTGATERREVFWEKRLYLQSYPNALPKVL 1082

Human  1774 QYYSAATEHDRSWYKAWHAWAVMN---FEAVLHYKHQNQARDEKKKLRHASGANITNATTAATTA 1835
            .              |.|:|...|   ..|:||                                
  Fly  1083 H--------------AAHSWDYANLIDLHALLH-------------------------------- 1101

Human  1836 ATATTTASTEGSNSESEAESTENSPTP-SPLQKKVTEDLSKTLLMYTVPAVQGFFRSISLSRGNN 1899
                                   |..| ||||       |..||:                    
  Fly  1102 -----------------------SWAPLSPLQ-------SLELLL-------------------- 1116

Human  1900 LQDTLRVLTLWFDYGHWPD--VNEALVEGVKAIQIDTWLQVIPQLI-------------AR---- 1945
                          ..:||  |.|..||.:..:..|..:..:|||:             ||    
  Fly  1117 --------------PRYPDAKVREKAVEWISKMPNDQLVDFLPQLVQSLKHDTYEGSAMARFLLS 1167

Human  1946 --IDTPR---PLVGRLIHQLLTD----IGRYHPQALIYPLTVASKSTTTARHNAANKILKNMCEH 2001
              :::||   .:...|:|.|..|    ||     |.:..........|..|:...||        
  Fly  1168 KCLESPRFAHHMYWLLVHSLPDDPHNSIG-----AAMVDQEYDESQVTQVRYYRRNK-------- 1219

Human  2002 SNTLVQQAMMV--SEELIRVAILWHEMWH------EGLEEASRLYFGERNVKGMFEVLEPLHAMM 2058
               ::.:|:|.  .|::::..:..|.|..      |.::||......:....||.||    |   
  Fly  1220 ---MMLRALMAICGEKMLQRFMYQHRMCQKLTTIAESVKEAKESMRQKSLAAGMDEV----H--- 1274

Human  2059 ERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKQLPQLTSLEL 2123
                             :||:| |..|                             ||....||:
  Fly  1275 -----------------QDLLE-QPTC-----------------------------LPLGPELEV 1292

Human  2124 QYVSPKLLMCRDLELAVPGTYDPNQPIIRIQSIAPSLQVITSKQRPRKLTLMGSNGHEFVFLLKG 2188
            ..||.:                             :.....|...|.|:..:|.:......:.|.
  Fly  1293 TGVSVR-----------------------------NCSYFNSNTLPLKINFVGPDAESLPAIFKC 1328

Human  2189 HEDLRQDERVMQLFGLVNTL-LANDPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRD 2252
            .:||:||:..:||..::|.: ||.     |.:|.:..:..:|....||:|..|...:||      
  Fly  1329 GDDLQQDQLTIQLIRIMNKMWLAE-----RLDLKMVTFNCVPTGYKSGMIELVSEAETL------ 1382

Human  2253 YREKKKILLNIEHRIMLRMAPDYDHLTLMQKVEVFEHAVNNTAGD-DLAKLLWLKSPSSEVWFDR 2316
                                         :|::| |..:..:..| .:|:.|..::||...:...
  Fly  1383 -----------------------------RKIQV-ECGLTGSFKDRPIAEWLGKQNPSPLEYQSA 1417

Human  2317 RTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKFP-EKIPFRLT 2380
            ..|:|.|.|..|:..|:||:.|||..|:|| :.||.:.|||||.....|.....|. ::.||.||
  Fly  1418 VRNFTLSCAGYSVATYVLGICDRHNDNIML-KTSGHLFHIDFGKFLGDAQMFGNFKRDRTPFVLT 1481

Human  2381 ---RMLTNAMEVTGLDGNYRI-TCHTVMEVLREHKDSVMAVL 2418
               ..:.|..:....|.:|.: .|.....::|::.|.::..|
  Fly  1482 SDMAYVINGGDKPSTDFHYFVDLCCRAFNIVRKNADLLLHTL 1523

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MTORNP_001373429.1 Interaction with NBN. /evidence=ECO:0000269|PubMed:23762398 1..651
TEL1 363..2549 CDD:227365 285/1472 (19%)
HEAT 16 637..683
HEAT repeat 655..681 CDD:293787
HEAT 17 686..724
HEAT repeat 691..721 CDD:293787
HEAT 18 727..766
HEAT repeat 729..759 CDD:293787
HEAT 19 769..811
HEAT repeat 772..805 CDD:293787
HEAT 20 814..853
HEAT repeat 817..847 CDD:293787
HEAT 21 857..893
HEAT 22 894..942
HEAT 23 943..988
HEAT repeat 955..981 CDD:293787
HEAT 24 989..1027
HEAT repeat 993..1021 CDD:293787
HEAT 25 1029..1068
HEAT repeat 1033..1062 CDD:293787
HEAT 26 1069..1105
HEAT repeat 1073..1099 CDD:293787
HEAT 27 1106..1144 9/27 (33%)
HEAT repeat 1111..1142 CDD:293787 8/25 (32%)
HEAT 28 1145..1188 16/74 (22%)
HEAT repeat 1154..1180 CDD:293787 10/54 (19%)
HEAT 29 1189..1225 10/39 (26%)
HEAT 30 1226..1273 11/51 (22%)
HEAT 31 1274..1311 13/44 (30%)
HEAT 32 1312..1345 5/32 (16%)
TPR 1 1346..1382 10/53 (19%)
TPR 2 1383..1408 9/28 (32%)
TPR 3 1409..1442 6/32 (19%)
TPR 4 1443..1473 7/41 (17%)
TPR 5 1474..1507 8/53 (15%)
TPR 6 1508..1541 6/33 (18%)
TPR 7 1542..1574 2/31 (6%)
TPR 8 1575..1614 7/38 (18%)
TPR 9 1615..1649 3/33 (9%)
TPR 10 1650..1693 11/42 (26%)
TPR 11 1694..1731 6/37 (16%)
TPR 12 1732..1786 12/69 (17%)
TPR 13 1787..1846 7/61 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1812..1867 5/55 (9%)
TPR 14 1898..1930 6/33 (18%)
TPR 15 1931..1970 14/64 (22%)
TPR 16 1971..2005 5/33 (15%)
Sufficient for interaction with the FKBP1A/rapamycin complex. /evidence=ECO:0000250 2012..2144 22/139 (16%)
Interaction with MLST8 2258..2296 3/37 (8%)
Pi3K68DNP_001163420.1 EIN3 <58..392 CDD:296674
PI3K_rbd 561..669 CDD:197540 33/129 (26%)
C2A_PI3K_class_II 844..1021 CDD:175979 39/260 (15%)
PI3Ka_II 1038..1202 CDD:238441 48/288 (17%)
PI3Kc_II 1235..1583 CDD:270710 86/414 (21%)
PX_PI3K_C2_68D 1611..1721 CDD:132794
C2B_PI3K_class_II 1751..1871 CDD:176027
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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