DRSC/TRiP Functional Genomics Resources

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Protein Alignment MTOR and mei-41

DIOPT Version :10

Sequence 1:NP_004949.1 Gene:MTOR / 2475 HGNCID:3942 Length:2549 Species:Homo sapiens
Sequence 2:NP_523369.2 Gene:mei-41 / 32608 FlyBaseID:FBgn0004367 Length:2517 Species:Drosophila melanogaster


Alignment Length:543 Identity:97/543 - (17%)
Similarity:186/543 - (34%) Gaps:194/543 - (35%)


- Green bases have known domain annotations that are detailed below.


Human   180 ASPATIEMAI------------ETLQK---------SDGLSTHRSSLLNSHLQWLL--------- 214
            ||..|||..|            |.|||         :|.::|..||.|...:.|:.         
  Fly   220 ASARTIENLIFSMCPIAESEHVEILQKLAGILMDNWADAVTTQPSSFLIRAIVWVCCGLSARPKV 284

Human   215 -----DNYETAEGVSLPRSTLYNHYLRHCQEHKLDPVNAASFGKLIRSIFMGLRTRRLGTRGNSK 274
                 .||:..|    .:::|.|.|         :.:...:|.:.:...||              
  Fly   285 GEEKKRNYKGQE----MKASLKNVY---------EKLAILAFDENLNKTFM-------------- 322

Human   275 YHYYGIRVKPDSPL------NRLQEDMQYMAMRQQPMQQKQRYKPMQKVDGVADGFTGSGQQTGT 333
                      |||:      :.::.|..:...|.....:|:..|  :.::|::..:..|      
  Fly   323 ----------DSPIFVTLFQDFIEADGLWGDKRGDEYVKKKLEK--EDIEGISKAWYSS------ 369

Human   334 SVEQTVIAQSQHHQQFLDASRALPEFGEVEISSLPDGTTFEDIKSLQSLYREHCEAILDVVVNLQ 398
                             :.||...:..|         |..||.:||  |:.|.|...:|.:.:.:
  Fly   370 -----------------NGSRVWDKLME---------TCSEDARSL--LWIEFCSKNVDELTDNR 406

Human   399 FS--LIEKLWQTFWRYSPSTPTDGTTITESSNLSEIESRLPKAKLITLCKHESILKWMCNCDHGM 461
            ||  .::|:      .:.||..:  .:||.     ||:..||..  :|.:|:         :.|:
  Fly   407 FSNFPLQKM------INSSTSLE--MVTEI-----IETMAPKCS--SLLEHQ---------NSGV 447

Human   462 YQALVEILIPDVLRPIPSA---LTQAIRNFAKSLEGWLSNAMNNIPQRMIQTKVAAVSAFAQTLR 523
            :.:::.     .....||:   :.|.:|.:.::                     |:.:...|.|.
  Fly   448 FLSVIR-----CAARYPSSEKTMLQQLRKYFRA---------------------ASEAKKGQFLL 486

Human   524 RYTSLNHLAQAARAVLQNTSQINQMLSDLNRVDFANVQEQASWVCQCDDNMVQRLETDFKMTLQQ 588
            ...:||....:.....:.|.:...::|:|  |:|:..:..|:...|..:..:|.:..: |.|   
  Fly   487 NVLTLNGCDGSIFDTQKFTQKGTMLVSEL--VNFSKTKTLATGFEQLSEQQIQEMSCN-KYT--- 545

Human   589 QSTLEQWAAWLDNVMMQALK----------PYEGRPSFPKAARQFLLKWSFY----SSMVIRDLT 639
             |.|.| |......|.:.:|          .:|...:....:|.|...|.|.    ...:::.|.
  Fly   546 -SRLIQ-AVLASKTMPEEIKEKIIGAFDKNSWETLITDTFGSRVFEKIWEFVDVKRKQEIMKVLV 608

Human   640 -LRSAASFGSFHLIRLLYDEYMF 661
             :.:::.|..|.::|.  |.|:|
  Fly   609 GIHNSSKFWKFAMLRC--DLYLF 629

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MTORNP_004949.1 Interaction with NBN. /evidence=ECO:0000269|PubMed:23762398 1..651 93/531 (18%)
TEL1 363..2549 CDD:227365 60/319 (19%)
HEAT 16 637..683 7/26 (27%)
HEAT repeat 655..681 CDD:293787 3/7 (43%)
HEAT 17 686..724
HEAT repeat 691..721 CDD:293787
HEAT 18 727..766
HEAT repeat 729..759 CDD:293787
HEAT 19 769..811
HEAT repeat 772..805 CDD:293787
HEAT 20 814..853
HEAT repeat 817..847 CDD:293787
HEAT 21 857..893
HEAT 22 894..942
HEAT 23 943..988
HEAT repeat 955..981 CDD:293787
HEAT 24 989..1027
HEAT repeat 993..1021 CDD:293787
HEAT 25 1029..1068
HEAT repeat 1033..1062 CDD:293787
HEAT 26 1069..1105
HEAT repeat 1073..1099 CDD:293787
HEAT 27 1106..1144
HEAT repeat 1111..1142 CDD:293787
HEAT 28 1145..1188
HEAT repeat 1154..1180 CDD:293787
HEAT 29 1189..1225
HEAT 30 1226..1273
HEAT 31 1274..1311
HEAT 32 1312..1345
TPR 1 1346..1382
TPR 2 1383..1408
TPR 3 1409..1442
TPR 4 1443..1473
TPR 5 1474..1507
TPR 6 1508..1541
TPR 7 1542..1574
TPR 8 1575..1614
TPR 9 1615..1649
TPR 10 1650..1693
TPR 11 1694..1731
TPR 12 1732..1786
TPR 13 1787..1846
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1812..1867
TPR 14 1898..1930
TPR 15 1931..1970
TPR 16 1971..2005
Sufficient for interaction with the FKBP1A/rapamycin complex. /evidence=ECO:0000250|UniProtKB:Q9JLN9 2012..2144
FKBP12-rapamycin binding domain 2025..2114
G-loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269 2162..2168
Interaction with MLST8 2258..2296
Catalytic loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269 2335..2343
Activation loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269 2355..2380
mei-41NP_523369.2 UME 955..1060 CDD:214825
FAT 1653..1985 CDD:396714
TEL1 <1946..2517 CDD:227365
PIKKc_ATR 2181..2448 CDD:270625
Blue background indicates that the domain is not in the aligned region.

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