DRSC/TRiP Functional Genomics Resources

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Protein Alignment MTOR and nonC

DIOPT Version :10

Sequence 1:NP_004949.1 Gene:MTOR / 2475 HGNCID:3942 Length:2549 Species:Homo sapiens
Sequence 2:NP_727132.1 Gene:nonC / 31625 FlyBaseID:FBgn0263968 Length:3218 Species:Drosophila melanogaster


Alignment Length:2384 Identity:492/2384 - (20%)
Similarity:859/2384 - (36%) Gaps:709/2384 - (29%)


- Green bases have known domain annotations that are detailed below.


Human   426 KEKERTAAFQALGL---LSVAVRSEFKVYLPRVLDIIRAALPPKDFAHKRQKAMQVDATVFTCIS 487
            |..:|...:..:.|   ||...:.|..:|..:::.::      |||....:.| .:...|...:.
  Fly   220 KSSKRMQKYMIMALRATLSCDTKCELHMYADKIMLLL------KDFLENAESA-DIFIVVSNTLV 277

Human   488 MLARAMGPGIQQDIKELLEPMLAVGLSPALTAVLYDLSRQIPQLKKDIQDGLLKMLSLVLMHKPL 552
            ..|.:.....:....::::.::...|......   ||.....|:.:.:.....|.:.        
  Fly   278 QFAASYAETFECHFTDVVDIVIGWQLEAGQPT---DLKTHCAQVLEQLTPFFSKQID-------- 331

Human   553 RHPGMPKGLAHQLASPGLTTLPEASD----------VGSITLALRTLGSFE-FEGHSLTQ-FVRH 605
                ...||..|... .:|||.|...          ||:....|:.|...: |.|....: .|:.
  Fly   332 ----FSYGLLDQFVE-DITTLEEGEPANTAERVGAFVGAFNTLLKCLARMQIFVGMPTCECIVKM 391

Human   606 CADHFLNSEHKEIRMEAARTCSRLLTPSIHLISGHAHVVSQTAVQVVADVLSKLLVVGITDPDPD 670
            ..||.:.                 :.|::||        :..|:..:.:::...|:...|..||.
  Fly   392 AVDHLIK-----------------IMPTLHL--------NTEALVNINELICICLLNNFTGLDPI 431

Human   671 IRYCVLASLDERFDAHLAQAENLQALFVALNDQVFEIRELAICTVGRL-SSMNPAFV------MP 728
            :...||....:|. ..|.:.:....|:            |.:|||.|| :.:.|:.|      .|
  Fly   432 LLEQVLLDQVKRM-ISLTELQRQSVLY------------LLLCTVRRLRARLTPSLVHFIFQSNP 483

Human   729 FLRKMLIQILTELEHSGIGRIKEQSARMLGHLVSNAPRLIRPYMEPILKALILKLKDPDPDPNPG 793
            ::.|:.::...|..:..:.|..:::.     |:.|.|.|.:.|     |.|:        |....
  Fly   484 YMTKVRLRSPGETSYKLLLRTCQETL-----LIRNVPLLQQAY-----KYLV--------DDIDA 530

Human   794 VINNVLATIGELAQVSGLEMRKWVDELFIIIMDMLQDSSLLAKRQVALWTLGQLVASTGYVVEPY 858
            .:..:|.|          ..|....:..::::..|...:.|||:             |..::..|
  Fly   531 CLEKLLIT----------APRSKARKASVLLVFHLSALAALAKQ-------------TSSIIGMY 572

Human   859 RKYPTLLEVLL-----NFLKTEQNQGTRREAIRVLGLLGALDPYKHKVNIGMIDQSRDASAVSLS 918
            ...|::||:||     :.||........::||  .|||..                         
  Fly   573 ACKPSILELLLTNCRAHELKFWSKYPAAQQAI--FGLLVV------------------------- 610

Human   919 ESKSSQDSSDYSTSEMLVNMGNLPLDEFYPAVSMVALMRIFRDQSLSHHHTMVVQAITFIFKSLG 983
               ..|.:.::.|:..|:                       |||.||..:|              
  Fly   611 ---HCQANHNFRTNSSLL-----------------------RDQELSAENT-------------- 635

Human   984 LKCVQFLPQVMPT---FLNVIRVCD---GAIREFLFQQLGMLVSFVKSHIRPYMDEIVTLMRE-- 1040
                      .||   |.:::|..|   |...:...|.|.:|:.:::..:|...::|..||.:  
  Fly   636 ----------SPTANSFASILRFLDSVLGQAHQLAPQNLRVLLQWIQMLLRECREKIDLLMEQEN 690

Human  1041 FWVMNTSIQSTIILLIE-------QIVVALGGEFKLYLPQLIPHMLRVFMHDNSPGRIVSIKLLA 1098
            |..:..:|.:|...|:.       |.|:..|.|.....|:|:     :...|.:         |.
  Fly   691 FRGICRNIAATASKLVPLESAACIQTVLDYGLERLEKYPKLL-----ILYRDTA---------LQ 741

Human  1099 AIQLFGAN-----LDDYLHLLLPPIVKLFDAPEAPLP---SRKAAL--ETVDRLTESLD--FTDY 1151
            .:|:...|     ...|..|   |:.......|:.:|   ||:.::  :.:.:.:...|  |.|:
  Fly   742 QLQMLSTNYHAPYFQIYAQL---PLHLTLTGGESSMPGMASRRVSVWQQRISQYSAVRDNVFRDF 803

Human  1152 ASRIIHP------------IVRTLDQSPELRSTAMDTLSSLVFQLGKKYQ-IFIPMVNKVLVRHR 1203
            ..|:..|            .||:...:|:      |.....:.|..|:.| :.|..:.....|:.
  Fly   804 FDRVQKPEQDSLIHCLRELFVRSCQVAPQ------DERQMNLSQCTKRCQRLAIAWLQFEAARYC 862

Human  1204 INHQRYDVLICRIVKGYTLADEEE-----DPLIYQHRMLRSGQGDALASGPVETGPMKKLHVSTI 1263
            :: ||...         |:...:|     :.:|.:|..|.||....:....::...:::|.....
  Fly   863 VD-QRLRT---------TVGKPQETFLGFEAIIMRHARLLSGCAKEIERSALDDLSLEELLSMQS 917

Human  1264 NLQKAWGAARRVSKDDWLEWLRRLSLELLKDSS---SPSLRSCWALAQAYNPMARDLFNAAFVSC 1325
            ||....|         :|:.|.:|.....:.|:   .|..:...|..:..||..:..||...:..
  Fly   918 NLSLLLG---------FLDALEKLIYNAAEGSAFALRPPEKQVAAFFRLNNPTCQSWFNRIRIGV 973

Human  1326 WSELNEDQQDEL-IRSIELALT---------SQDIAEVTQTLLNLAEFMEHSDKGPLPLRDDNGI 1380
            .......||.|| ||..:..|.         ||.|..:..:|::..|  ..|.:|   ||     
  Fly   974 VIIAMHVQQPELVIRYAQQILVNSKTQDPTYSQAIVYMAWSLVSCQE--ADSLRG---LR----- 1028

Human  1381 VLLGERAAKCRAYAKALHYKELEFQKGPTPAILESLISINNKLQQPEAAAGVLEYAMKHF----G 1441
              |..|...|::| |.|.|                         ..:.|||..|.|:..:    .
  Fly  1029 --LWARGKSCKSY-KWLKY-------------------------AADQAAGKRESALAGYRTILA 1065

Human  1442 ELEIQATWYEKLHEWEDALVAYDKKMDTNKDDPELMLGRMRCLEALGEWGQL----HQQ------ 1496
            |.|:|:           .|..:.::...::        .|:||:.||:|.||    .||      
  Fly  1066 EKELQS-----------ELEPHTRQFVVSQ--------MMQCLQDLGQWSQLVELKQQQMTRPED 1111

Human  1497 ---------------CCEKWTLVNDETQAKMARMAAA----AAWGLGQWDSMEEYTCMIPRDTHD 1542
                           ..|:....::|:.:.|..:...    :.|. ..||.....:.:..|.:..
  Fly  1112 RELNPFLQRSNVEVNALERLLAKSEESCSSMDALGGVFQQLSLWP-SNWDESVSSSGLSERASFS 1175

Human  1543 GAFYR---AVLALHQDLFSLAQQCI-DKARDLLDAE-LTAMAGESYSRAYGAMVSCHMLSELEEV 1602
            ....|   ..:.||:   .|..:|: |:|::|||.: ..::...|:.:.     ||..|:.|..:
  Fly  1176 SIHMRQRTEDIVLHK---LLEDRCVPDQAKNLLDTQWRDSLLNPSFDQR-----SCKELTLLRHI 1232

Human  1603 IQ-------YKLVP------ERRE-------IIRQIWWERL--QGCQRIVEDWQKILMVRSLVVS 1645
            :|       ..|:|      :.|.       ::|.:.|.:|  |.|  ....|:.:.        
  Fly  1233 VQGVSGGQELSLLPVSSGRCQNRSKFISSAILMRCLAWTQLLRQHC--APGSWETLC-------- 1287

Human  1646 PHEDMRTWLKYASLCGKSGRLALAHKTLVLLLG-----VDPSRQLDHPLPTVHPQVTYAYMKNMW 1705
                    |..|:...:.|.|.||...|....|     :.....|:..:.|.:|::...|     
  Fly  1288 --------LDAAAAAREEGNLQLAETLLTQFFGQPIGEIAALFSLEQGVQTDNPEMLRGY----- 1339

Human  1706 KSARKIDAFQHMQHFVQTMQQQAQHAIATEDQQHKQELHKLMARC-------------------- 1750
               .::....|:|      |||:        |.|..:|...:..|                    
  Fly  1340 ---SELVKCLHLQ------QQQS--------QTHSGDLSSSIDVCAALCLNIQKSNNQPAAGADL 1387

Human  1751 FLKLGEW--QLNLQGINESTIPKVLQYYS---------------AATEHDRSWYKAWHAWAVM-- 1796
            .|.|.:|  .....|:..:..|.::|...               |..:.:|...:..|:....  
  Fly  1388 LLNLADWIAVRTCNGLTTNQSPVLIQLLDQLPECPLTCDSSQPLAIPQAERMVARLVHSCLQQRP 1452

Human  1797 NF-EAVLHYKHQNQARDEKKKLRHASGANITNATTAATTA-ATATTTASTEGSNSESE------- 1852
            |: ||::.|.:          ..:..|..:.::....|.| |||.:.|.......|||       
  Fly  1453 NYAEALIAYGN----------WCYRWGKKVADSCCVLTQADATAISQALDIPQPLESEKLDELLQ 1507

Human  1853 AESTENSPT------PSP------------------LQKKVTEDLSKTLLM----------YTVP 1883
            |.|||..|.      |..                  |..|..|.|...|.:          |...
  Fly  1508 ALSTEQPPANCVEVCPDAARARDDEAAKNRLRRLTFLADKTPEALDAILQIWRRAIANTYDYYKD 1572

Human  1884 AVQGFFRSISLSRG-----------------------NNLQDTLRVLTLWFDYGHWPDVNEALVE 1925
            |.:.:|:.:|...|                       |.:..|||:|.|...  |...:.|.|.:
  Fly  1573 AARSYFQYLSFKSGSGPEKPEGEGVVSQRERLHVDDSNLVTTTLRLLRLIVK--HASGLQEVLEQ 1635

Human  1926 GVKAIQIDTWLQVIPQLIARIDTPRPLVGRLIHQLLTDIGRYHPQALIYPLTV--------ASKS 1982
            |:....|..|..:||||.:|::...|.|.:.:..||..:.:..||.:|:|..|        |:..
  Fly  1636 GLHTTPIAPWKVIIPQLFSRLNHHEPYVRKSVCDLLCRLAKSRPQLVIFPAVVGANREQQDATAP 1700

Human  1983 TTTARHNAANK-----ILKNMCEHSNTLVQQAMMVSEELIRVAILWHEMWHEGLEEASRLYF--- 2039
            ..|||....:.     :|..:.:.:...||...::.:||.||.:||.|.|...|......|.   
  Fly  1701 PATARPTTEDACCYGYLLGELSKQAPEAVQHVKLMVKELRRVCLLWDEYWIHSLAHIYNTYVSRV 1765

Human  2040 -------------GERNVKGMFEV--------LEPLHAMMERGPQTLKETSFNQAYGRDLMEAQE 2083
                         |:.|   .|.|        ||.|.|:..|.|:|..|.||.:.:...:....:
  Fly  1766 SALATDFRPDDHEGKNN---RFNVWRPQLLADLEALVAVTSRPPETTYERSFRKRFDAPIRLTVD 1827

Human  2084 WCRKYMKSGNVKDLTQAWD---LYYHVFRRISKQL-PQLTSLELQYVSPKLLMCRDLELAVPG-- 2142
            ..|.       :...:|||   ..||:.:  |..: ...::|::|.:||.|.....:.:::||  
  Fly  1828 ALRH-------RRYPEAWDKLKQLYHILQ--SNMIRGSGSTLKMQSISPVLCGIGRMRISMPGLD 1883

Human  2143 TYDPNQPIIRIQSIAPSLQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNT 2207
            .:.|:...:.|:|:..|:.|:.:|.:|:|:...||||..:.||.||.|||..|||:||...:.|.
  Fly  1884 AHGPDGDQVYIESVESSVCVLPTKTKPKKVAFYGSNGQRYTFLFKGMEDLHLDERIMQFLSISNA 1948

Human  2208 LLANDPTSLRKN------LSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKK-------- 2258
            ::|     .|.:      .....|:||||...||||.||.....:.||.:.:::::.        
  Fly  1949 IMA-----CRSDAPGNGCYRAHHYSVIPLGPQSGLISWVDGVTPVFALYKKWQQRRSQVAGNAGA 2008

Human  2259 -ILLNIEHRIMLRMAPD--YDHLT-LMQK-----------------VEVFEHAVNNTAGDDLAKL 2302
             .:.|:..|.     .|  |:.|: |:.|                 ::|.:.....|..|.||:.
  Fly  2009 GAVANVPRRF-----TDLFYNKLSPLLAKHNMQVSDPRRQWPISVLLQVLDELSQETPNDLLARE 2068

Human  2303 LWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMT 2367
            ||.::.::..|......:.|.::||||:||::||||||..|::::..||.|:|||:..|||...|
  Fly  2069 LWCQAGNAAEWRQSVRRFVRCMSVMSMIGYVIGLGDRHLDNVLINLGSGDIVHIDYNVCFEKGRT 2133

Human  2368 REKFPEKIPFRLTRMLTNAMEVTGLDGNYRITCHTVMEVLREHKDSVMAVLEAFVYDPLLNWRLM 2432
            . :.|||:|||||:.|..||.:||::|.:|:.|..|::|:|:.:::::.:|||||||||::|...
  Fly  2134 L-RIPEKVPFRLTQNLVQAMGITGIEGPFRLGCEYVLKVMRKERETLLTLLEAFVYDPLVDWTTN 2197

Human  2433 DTNTKGNKRS-----RTRTDSYSAGQSVEILDGVELGE-PAHKK 2470
            | :.:..:||     :...|...||       |:.:|: ..|||
  Fly  2198 D-DAQALRRSLNAKLQESADGGGAG-------GLGVGDLKYHKK 2233

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MTORNP_004949.1 Interaction with NBN. /evidence=ECO:0000269|PubMed:23762398 1..651 38/239 (16%)
TEL1 363..2549 CDD:227365 492/2384 (21%)
HEAT 16 637..683 7/45 (16%)
HEAT repeat 655..681 CDD:293787 6/25 (24%)
HEAT 17 686..724 8/38 (21%)
HEAT repeat 691..721 CDD:293787 7/30 (23%)
HEAT 18 727..766 6/38 (16%)
HEAT repeat 729..759 CDD:293787 3/29 (10%)
HEAT 19 769..811 6/41 (15%)
HEAT repeat 772..805 CDD:293787 5/32 (16%)
HEAT 20 814..853 6/38 (16%)
HEAT repeat 817..847 CDD:293787 4/29 (14%)
HEAT 21 857..893 13/40 (33%)
HEAT 22 894..942 3/47 (6%)
HEAT 23 943..988 6/44 (14%)
HEAT repeat 955..981 CDD:293787 6/25 (24%)
HEAT 24 989..1027 9/43 (21%)
HEAT repeat 993..1021 CDD:293787 9/33 (27%)
HEAT 25 1029..1068 11/47 (23%)
HEAT repeat 1033..1062 CDD:293787 9/37 (24%)
HEAT 26 1069..1105 5/35 (14%)
HEAT repeat 1073..1099 CDD:293787 3/25 (12%)
HEAT 27 1106..1144 8/47 (17%)
HEAT repeat 1111..1142 CDD:293787 6/35 (17%)
HEAT 28 1145..1188 11/56 (20%)
HEAT repeat 1154..1180 CDD:293787 6/37 (16%)
HEAT 29 1189..1225 6/36 (17%)
HEAT 30 1226..1273 10/51 (20%)
HEAT 31 1274..1311 6/39 (15%)
HEAT 32 1312..1345 9/33 (27%)
TPR 1 1346..1382 9/44 (20%)
TPR 2 1383..1408 7/24 (29%)
TPR 3 1409..1442 5/36 (14%)
TPR 4 1443..1473 3/29 (10%)
TPR 5 1474..1507 11/57 (19%)
TPR 6 1508..1541 5/36 (14%)
TPR 7 1542..1574 10/35 (29%)
TPR 8 1575..1614 9/58 (16%)
TPR 9 1615..1649 6/35 (17%)
TPR 10 1650..1693 10/47 (21%)
TPR 11 1694..1731 7/36 (19%)
TPR 12 1732..1786 12/90 (13%)
TPR 13 1787..1846 12/62 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1812..1867 17/86 (20%)
TPR 14 1898..1930 10/31 (32%)
TPR 15 1931..1970 11/38 (29%)
TPR 16 1971..2005 8/46 (17%)
Sufficient for interaction with the FKBP1A/rapamycin complex. /evidence=ECO:0000250|UniProtKB:Q9JLN9 2012..2144 38/161 (24%)
FKBP12-rapamycin binding domain 2025..2114 25/115 (22%)
G-loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269 2162..2168 2/5 (40%)
Interaction with MLST8 2258..2296 9/66 (14%)
Catalytic loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269 2335..2343 6/7 (86%)
Activation loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269 2355..2380 13/24 (54%)
nonCNP_727132.1 SMG1 571..1140 CDD:464869 137/744 (18%)
PIKKc_SMG1 1894..2196 CDD:270714 107/312 (34%)
FATC 3189..3217 CDD:460514
Blue background indicates that the domain is not in the aligned region.

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