DRSC/TRiP Functional Genomics Resources

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Protein Alignment MTOR and Pi4KIIIalpha

DIOPT Version :9

Sequence 1:NP_001373429.1 Gene:MTOR / 2475 HGNCID:3942 Length:2549 Species:Homo sapiens
Sequence 2:NP_001259191.1 Gene:Pi4KIIIalpha / 31247 FlyBaseID:FBgn0267350 Length:2154 Species:Drosophila melanogaster


Alignment Length:2604 Identity:509/2604 - (19%)
Similarity:850/2604 - (32%) Gaps:923/2604 - (35%)


- Green bases have known domain annotations that are detailed below.


Human   297 DKY-------CKDLMGFGTKPRHITPFTSFQAV---QPQQSNALVGLLGYSSHQGLMGFGTSPSP 351
            |||       |...:..|.:|   ||:...|.:   .||::.|.|..|...:...::..|.    
  Fly     7 DKYTYQRTVLCLARVLAGIQP---TPWDKVQTLFRYCPQENAAGVFCLDTRAQDAVIALGI---- 64

Human   352 AKSTLVESRCCRD-------LMEEKFDQVCQWVLKCRNSKNSLIQMT-------ILN-LLPRLAA 401
               ..:|..|..:       |...|......|:...|::|...:::.       .|| ||..:||
  Fly    65 ---YFLEGGCQHEGQIVPYLLRLAKCLPKAVWIDDARSNKVERVRIPSAEKFSFCLNTLLSDIAA 126

Human   402 FRPSAFTDTQYLQ-DTMNHVLSCVKKEKERTAAFQALGLLSVAVRSEFKVYLPRVLDIIRAALPP 465
            ..|.:..:....| :|::.:.:.||..::.::|                   |..:.:.:|.:| 
  Fly   127 KCPDSREEIILNQVETLSALANIVKSSRDSSSA-------------------PPPIILCKATVP- 171

Human   466 KDFAHKRQKAMQVDATVFTCISMLARAMGPGIQQDIKELLEPMLAVGLSPALTAVLYDLSRQIPQ 530
                               .:..|||:||.....|     .|:|.....|.|          :|.
  Fly   172 -------------------LLFGLARSMGRYASND-----PPLLCRIFPPEL----------LPI 202

Human   531 LKKDIQDGLLKMLS--------------LVLMH--KPLRHPGMPKGLA----------HQLASPG 569
            .|...:||.....|              |...|  :|:....|...||          .|..:.|
  Fly   203 QKGGGRDGTGSSSSASGTCGGSFSSSERLAATHHFRPIIPRSMSGSLAQAQNASYDDGRQRCAGG 267

Human   570 LTTLPEASDVGSITLALRTLGSFEFEGHSLTQF--VRHCADHFLNSEHKEIRMEAARTCSRLLTP 632
            ..:.|......|:....|| ..|...|.|..||  :|.|............|:..        .|
  Fly   268 KPSKPSLHSYFSVPYDPRT-HFFTRYGSSFNQFPNMRVCESPTKGGPRPLYRVPP--------FP 323

Human   633 SIHLISGHAHVVSQTAVQVVADVLSKLLVVGITDPDPDIRYCVLASLDER----FDAHLAQ---- 689
            ..||             |.:..|..|||...           .|..|||:    |..|..:    
  Fly   324 IQHL-------------QTIFAVSKKLLTKD-----------TLEHLDEQASDIFSLHQIKGYCY 364

Human   690 ---AENLQALFVALNDQVFEIRELAICTVGRLSSMNPAFVMPFLRKMLIQILTEL---------- 741
               :|.|..:.|.|      :|||....|. |.:.....|..|::::.:...|||          
  Fly   365 KSFSETLNLVLVTL------LRELLQHQVD-LPTPFTKDVQEFVKRLFLNGQTELQNKQQDQERE 422

Human   742 --EHSGIGRIKEQSARMLGHLVSNAPRLIRPYMEPILKALILKLKDP--DPDPNPGVINNVLATI 802
              |.:||..:.:...    ::::||         ..:..|:..::|.  |.|.|...:.|.|..:
  Fly   423 RREENGIAVVNKYKV----NVMANA---------ACVDLLVWAIRDETVDVDYNVPSLQNGLQFL 474

Human   803 ---------GELAQVSGLEMRKWVDELFIIIMDMLQDSSLLAKRQVALWTLGQLVASTGYVVEPY 858
                     |.|:|...||:.      ..|:||.:   .||   .|.|..||:|.          
  Fly   475 LKKEADKLCGRLSQKLNLELS------HKIVMDHM---PLL---MVCLEGLGKLA---------- 517

Human   859 RKYPTLLEVLLNFLKTEQNQGTRREAIRVLGLLGALDPYKHKVNIGMIDQSRDAS------AVSL 917
            .|:|.:....:::|        |...:....:||.|  :.|.:. .:..|.::..      ||..
  Fly   518 HKFPNIAGTSISYL--------RDFLVAPSPILGKL--HDHAMQ-SLAQQKKEKELTPFKIAVQH 571

Human   918 SESK--------------SSQDSSDYSTSEML--VNMGNL--------PLDEF-YPAVSMVALMR 957
            |:|:              |....|.::..|.|  ..:.||        .||:| .||:......|
  Fly   572 SDSRTAVVIYGDNQKPPGSGTGRSGHAAFESLRDAAIENLSIALRAAHTLDQFCVPALVANVSNR 636

Human   958 IF-------RDQSLSHHHTMVVQAITFIFKSLGLKCVQFLPQVMPTFLNVI-----RVCDGAIRE 1010
            :|       ..|...|...:|...|..:   ||...|. |.....|..|::     |.|.....:
  Fly   637 LFTAEKSGSESQGECHKSNLVSLNIIVM---LGHVAVA-LKDTSKTTQNILQFFIQRFCKVPSEQ 697

Human  1011 --FLFQQLG-MLVSFVKSHIRPYMDEIVTLMREFWVMNTSIQSTIILLIEQIVVALGGEFKLYLP 1072
              .:..||| |::|..::|:   .|||:.:.....|.:.|:..|                     
  Fly   698 NALIVDQLGCMIISQCETHV---FDEIMKMFSRVTVQSASLAYT--------------------- 738

Human  1073 QLIPHMLRVFMHDNSPGRIVSIKLLAAIQLFGANL--DDYLHLLLPPIVKLFDAPEAPLPSRKAA 1135
             ..|...:.|.|       ||..::.|:....||:  |..:..||..:::||             
  Fly   739 -SDPEHRKQFHH-------VSDAVVNALGNIAANIQGDAEMLELLGKLLELF------------- 782

Human  1136 LETVDRLTESLDFTDYASRIIHPIVRTLDQSPELRSTAMDTLSSLVFQLGKKYQIFIPMVNKVLV 1200
                  :...||..           |:.|.:|..:..     ||....||    :.||:: .|||
  Fly   783 ------VQIGLDGE-----------RSYDNTPGAQKA-----SSRAGNLG----MLIPVI-AVLV 820

Human  1201 ---------RHRINHQRYDVLICRIVKGYTLADEEEDPLIYQHRMLRSGQGDALASGPVETGPMK 1256
                     |.|::....|.....:|.|:|.|                                 
  Fly   821 RRLPPIKNPRQRLHKLFKDFWAYCVVMGFTNA--------------------------------- 852

Human  1257 KLHVSTINLQKAWGAARRVSKDDWLEWLRRLSLELLKDSSSPSLRSCWALAQAYNPMARDLFNAA 1321
                      :.|.|       ||.:.:::::      :.||.|.|                ..|
  Fly   853 ----------RLWPA-------DWYQGVQQIA------AKSPLLIS----------------QTA 878

Human  1322 FVSCWSELNEDQQDELIRSIELALTSQDIAEVTQTLLNLAEFMEHSDKGPLPLRDDNGIVLLGER 1386
            ..|...|||          ..||:.|..:.|:...:|.|   :|||        .||....:.:.
  Fly   879 HKSDMRELN----------YTLAIKSDSVNELRSQILVL---LEHS--------SDNVATAINKL 922

Human  1387 A-AKCRAYAKALHYKE-LEFQKGPTPAILESLIS--INNKLQQPE---------AAAGVLE---- 1434
            : |:| .|..::::.| |..:....|: ||.::|  .:..||:.:         .|..|.|    
  Fly   923 SFAQC-TYLLSVYWLEMLRVENADEPS-LEPIMSYLCDTALQRDKTGIWQCVKCVADQVFEKFRN 985

Human  1435 --YAMKHFGE--LEIQAT----WYEKLHE---------------------WED----------AL 1460
              ||.....|  ||.|||    ::..:|:                     |..          .|
  Fly   986 VLYAHDEIREKVLESQATLLLVYFNHIHKPIQMVADQYLSFLVDRFPHLLWNRRVLWCMLDILQL 1050

Human  1461 VAYDKKMDTNKDDPELMLGRMRCLEALGEWGQLHQQCCEKWTL-VNDETQAKMARMAAAAAWGLG 1524
            :||...:|.|::.|.|.:                  ....:|| :.|...|:..|:...|....|
  Fly  1051 LAYSLSLDPNEETPTLRV------------------VSTPYTLQLMDSLPARELRLKDFADRCQG 1097

Human  1525 ------QW------DSMEEYTCMIPRDT---HDG---AFYRAV--LALHQDLFSLAQQCI----- 1564
                  :|      ..::||...||...   |.|   ||...|  .|.|....|....|:     
  Fly  1098 IVNEAMKWAPRSTRSHLQEYPNQIPTPVLAHHSGLALAFDSVVSSSAQHTGTMSKRPSCVNSDTP 1162

Human  1565 --------------------------DKA--RDLLDAEL-TAMAGESYSRAYGAM--VSCHML-- 1596
                                      |||  .|.|.::: .|.|.:|.:|..||:  .:.:::  
  Fly  1163 RFVSVLCLRSKYAGEISGLLSVLSEKDKAGLADRLVSDVWEACAEKSDARHRGALWRATAYLIIC 1227

Human  1597 SELEEVIQYKLVPERREIIRQIWWERLQGCQRIVEDWQKILMVRSLVVSPHEDMRTWLKYASLCG 1661
            ||:...:.:.:...:.|:..:      ...:..||.||.:|..|       :|:       .||.
  Fly  1228 SEISRKLLHAVASSQLELFTE------SAMETAVECWQWVLTAR-------QDL-------ELCF 1272

Human  1662 KSGRLALAHKTLVLLLGVDP-SRQLDHPLPT------------VHPQVTY-AYMKNMWKSAR--- 1709
            ....::....|....:|:.. ..::.|||..            :.|.:.: ..:..|..:|:   
  Fly  1273 IQEMVSAWQTTFEKRMGLFAWETEVTHPLAAYEGCKLVSKPILIAPHLIWLQLLSEMVDTAKYCN 1337

Human  1710 --KIDAFQHMQH----FVQTMQQQAQHAIATEDQQHKQELHKLMARCFLKLGEWQLNLQGINEST 1768
              |::.|..:.|    .:::.:|..|  ::|...:.|      :.:|.|.|      |||   :|
  Fly  1338 RDKVEMFCLLLHRCLPVLKSSKQNRQ--VSTVGCRFK------LLQCGLSL------LQG---NT 1385

Human  1769 IPKVL-------QYYSAATEH--------DRSWYKAWHAWAVMNFEAVLHYKHQNQARDEKKKL- 1817
            |||.|       :.||.|.::        ::|..:...       :.::..|.....|.|||.| 
  Fly  1386 IPKSLSRNILRERIYSNALDYFCGPPTCPNQSREQLLE-------DIMILLKFWQTMRSEKKHLV 1443

Human  1818 -RHASGANITNATTAAT----------TAA-----------TATTTASTE-----------GSNS 1849
             ......::|||:.::|          ||:           |.:.:||..           ||:|
  Fly  1444 TSEVGDYDLTNASVSSTQMLAVRNNPETASLISGGGLVNDYTRSMSASGNAVGMGMGVAGGGSSS 1508

Human  1850 -------ESEAESTENSPTPSPLQ-KKVTED---LSKTLLMYTVPAVQGFFRSISLSRGNNLQDT 1903
                   .|.:..::.|.....|| :|.:.|   :.|..|:..:.||:..| .|:....|:|.|.
  Fly  1509 GWYNTIPHSTSTLSKRSNRSKRLQYQKDSYDKDYMKKRNLILELLAVELEF-LITWYNPNSLPDL 1572

Human  1904 L--------------RVLTLWFDYGH--W---PDVNEALVEGVKAIQ-IDTWLQ----------- 1937
            :              ...|:|.||..  |   |.:...|.:.:|..: ||..:.           
  Fly  1573 IVPGEEQITEWRNRPYKSTVWRDYARLAWCYNPALAVFLPQRIKNAEIIDEEVSRLVCSDPIAVC 1637

Human  1938 VIPQLIARIDTPRPLVGR---LIH----------QLLTDIGRYHPQALIYPLTVASKSTTTARHN 1989
            .||:.:..:.|.:.|:..   |::          |.|....|.:|.   :||| |..:..|....
  Fly  1638 HIPEALKYLCTTKNLLQESPDLVYILSWSPVTPIQALAYFSRQYPS---HPLT-AQYAVKTLSSY 1698

Human  1990 AANKILKNMCEHSNTLVQQAMMVSEELI-----RVAILWHEM-WHEGLEEASRLYFGE---RNVK 2045
            .|..:|..:.:....|....|....|.|     |..|:.|:: |:    ..:.:|..|   ....
  Fly  1699 PAESVLPYIPQLVQALRHDTMGYVVEFIKNISRRSQIVAHQLIWN----MQTNMYMDEDQQHKDP 1759

Human  2046 GMFEVLEPLH----AMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYH 2106
            .::|.|:.|.    |......:...|..|: .:|:....:.| .|.:.|....|:...|      
  Fly  1760 NLYEALDQLSQSIIASFSGAAKRFYEREFD-FFGKITAVSGE-IRSFAKGIERKNACLA------ 1816

Human  2107 VFRRISKQ-------LPQLTSLELQYVSP---------------KLLMCRDLELAVPGTYDPNQP 2149
            ...||..|       .|:...|::.|.|.               ::..|...||........|.|
  Fly  1817 ALSRIKVQGGCYLPSNPEAMVLDIDYSSGTPMQSAAKAPYLARFRVYRCGITELETRAMEVSNNP 1881

Human  2150 IIRIQSIAPSLQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPT 2214
                           :.|...|:||...:....:|  |..:|:|||...:|    |.|:..|...
  Fly  1882 ---------------NSQEDAKMTLGVESWQAAIF--KVGDDVRQDMLALQ----VITIFKNIFQ 1925

Human  2215 SLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLNIEHRIMLRMAPDYDHLT 2279
            .:..:|.:..|.|:..:...|:|..||:..:...|.|.                          |
  Fly  1926 QVGLDLFLFPYRVVATAPGCGVIECVPNAKSRDQLGRQ--------------------------T 1964

Human  2280 LMQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRHPSNL 2344
            .....|.|:|..    ||:          ||:.:...|.|:.:|:|..|::||:|.:.|||..|:
  Fly  1965 DSGLSEYFQHQY----GDE----------SSKEFQAARANFVKSMAAYSLIGYLLQIKDRHNGNI 2015

Human  2345 MLDRLSGKILHIDFGDCFEVAMTREKFP-EKIPFRLTRMLTNAMEVTGLDGN-----YRITCHTV 2403
            |:|: .|.|:|||||..||.:      | ..|.|.....||:.| |..:.|.     ::..|...
  Fly  2016 MIDK-DGHIIHIDFGFMFESS------PGGNIGFEPDMKLTDEM-VMIMGGKMDSPAFKWFCELC 2072

Human  2404 ME---VLREHKDSVMAVLEAFVYDPLLNWRLMDTN--------TKGNKRS--------------- 2442
            ::   .:|.::|::::::...:...|..:|....|        ||.||.:               
  Fly  2073 VQAFLAVRPYQDAIVSLVSLMLDTGLPCFRGQTINLLKQRFVATKNNKEAAAHMLAVIRNSYQNF 2137

Human  2443 RTRT 2446
            ||||
  Fly  2138 RTRT 2141

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MTORNP_001373429.1 Interaction with NBN. /evidence=ECO:0000269|PubMed:23762398 1..651 75/407 (18%)
TEL1 363..2549 CDD:227365 492/2528 (19%)
HEAT 16 637..683 9/49 (18%)
HEAT repeat 655..681 CDD:293787 6/25 (24%)
HEAT 17 686..724 10/44 (23%)
HEAT repeat 691..721 CDD:293787 9/29 (31%)
HEAT 18 727..766 9/50 (18%)
HEAT repeat 729..759 CDD:293787 7/41 (17%)
HEAT 19 769..811 10/52 (19%)
HEAT repeat 772..805 CDD:293787 8/43 (19%)
HEAT 20 814..853 10/38 (26%)
HEAT repeat 817..847 CDD:293787 9/29 (31%)
HEAT 21 857..893 5/35 (14%)
HEAT 22 894..942 13/77 (17%)
HEAT 23 943..988 13/52 (25%)
HEAT repeat 955..981 CDD:293787 6/32 (19%)
HEAT 24 989..1027 10/45 (22%)
HEAT repeat 993..1021 CDD:293787 8/35 (23%)
HEAT 25 1029..1068 6/38 (16%)
HEAT repeat 1033..1062 CDD:293787 5/28 (18%)
HEAT 26 1069..1105 6/35 (17%)
HEAT repeat 1073..1099 CDD:293787 5/25 (20%)
HEAT 27 1106..1144 6/39 (15%)
HEAT repeat 1111..1142 CDD:293787 4/30 (13%)
HEAT 28 1145..1188 9/42 (21%)
HEAT repeat 1154..1180 CDD:293787 4/25 (16%)
HEAT 29 1189..1225 12/44 (27%)
HEAT 30 1226..1273 2/46 (4%)
HEAT 31 1274..1311 6/36 (17%)
HEAT 32 1312..1345 6/32 (19%)
TPR 1 1346..1382 9/35 (26%)
TPR 2 1383..1408 5/26 (19%)
TPR 3 1409..1442 11/49 (22%)
TPR 4 1443..1473 12/64 (19%)
TPR 5 1474..1507 4/33 (12%)
TPR 6 1508..1541 9/47 (19%)
TPR 7 1542..1574 13/69 (19%)
TPR 8 1575..1614 8/43 (19%)
TPR 9 1615..1649 6/33 (18%)
TPR 10 1650..1693 7/55 (13%)
TPR 11 1694..1731 8/46 (17%)
TPR 12 1732..1786 16/68 (24%)
TPR 13 1787..1846 15/92 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1812..1867 20/96 (21%)
TPR 14 1898..1930 11/50 (22%)
TPR 15 1931..1970 10/63 (16%)
TPR 16 1971..2005 7/33 (21%)
Sufficient for interaction with the FKBP1A/rapamycin complex. /evidence=ECO:0000250 2012..2144 30/166 (18%)
Interaction with MLST8 2258..2296 4/37 (11%)
Pi4KIIIalphaNP_001259191.1 PI4Ka 1600..1775 CDD:238443 35/182 (19%)
PI4Kc_III_alpha 1836..2153 CDD:270711 84/375 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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