DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ret and Cad96Ca

DIOPT Version :9

Sequence 1:	NP_036775.2	Gene:	Ret / 24716	RGDID:	3556	Length:	1115	Species:	Rattus norvegicus
Sequence 2:	NP_651349.1	Gene:	Cad96Ca / 43026	FlyBaseID:	FBgn0022800	Length:	773	Species:	Drosophila melanogaster

Alignment Length:	1039	Identity:	260/1039 - (25%)
Similarity:	390/1039 - (37%)	Gaps:	381/1039 - (36%)

- Green bases have known domain annotations that are detailed below.

  Rat    25 APLGLYFSRDAYW------------ERLYVDQPAGTPLLYVHALRDAPGEVPSFRL--GQYLYGV 75
            ||..||. |:..|            :|:..:.|.|..|::        |..|.|.|  |
  Fly    53 APPILYV-RERNWRISETEKVGQIIDRVRAEDPDGDDLIF--------GIEPRFSLPGG------ 102

  Rat    76 YRTRLHENDW-------IHIDSGTGLLYLNQSLDHSSWEQ----LSIRNGGFPLLTVFLQVFLGS 129
                  |||.       ..||..||::.||:||...:.:.    :::.:|.:   |...:||:..
  Fly   103 ------ENDASPPEKIPFQIDRETGVVTLNESLAGRAGQNFLIYITVTDGSY---TAKNEVFINI 158

  Rat   130 TAQREGECHWPGCARVYFSFINDTFPNCSSFKARDLCTPETGVS---FRIRENRPPGTFYQFRML 191
            ..:||                     |.|.::      |:|.:|   ..|.:..|     :|..|
  Fly   159 LGERE---------------------NSSGYR------PQTSISNVVHNISQFLP-----RFDQL 191

  Rat   192 P-VQFLCPNISVKYKLLEGDGLPFRCDPDCLEVSTR---WALDRELQEKYVLEAECAVAGP---G 249
            | ||      |::      :|||          ::|   |         |....:..:.||   |
  Fly   192 PGVQ------SIR------NGLP----------NSRPGGW---------YPPVPQNNIFGPPPFG 225

  Rat   250 ANKEKVAVSFPVTVYDEDDSPPTFSGGVGTASAVVEFKRKEGTVVATLQVFDADVVPASGELVRR 314
            .|       :|       ..||...|..|..|.  |.::.:..|..|..|..:...|.|...:..
  Fly   226 NN-------YP-------PPPPNIPGVRGEQSG--EEEQPDEEVTPTTPVRISSTTPKSRTKLTP 274

  Rat   315 YTSTLLSGDSWAQQTFRVEHT-PNETLVQS----NNNSVRATMHNYKLVLNRSLSISESRVLQLV 374
            .|         |..:.|||.. |.||...|    ||:|...|:.:.|           |..:.:|
  Fly   275 IT---------ANNSTRVESAIPAETTTPSGGHHNNSSSPITIFSLK-----------SGTIPIV 319

  Rat   375 VLVNDSDFQGPGSGVLFLHFNVSVLPVTLNLPMAYSFPVNRRARRYAQIGKVC--VENCQEFSGV 437
            |.|          |..|         |.:.:.:||..     .||...|.:..  .:..:|.:..
  Fly   320 VTV----------GGFF---------VAIAVLLAYLC-----RRRLCAISRTLKKTKEKEELAKK 360

  Rat   438 SIQYKLQPSSTNCSALGVVTSTEDTSGTLYVNDTEALRRPECTELQYTVVATDRQTRRQT-QASL 501
            |.|.:|..           |.|:|:..::.:...:.   |.....:|.....|:|....| |.|.
  Fly   361 SNQSQLSS-----------TLTDDSRNSMVMQQWQG---PVAFANRYVPWERDQQMGIATSQLST 411

  Rat   502 VVTVEGTYIAEEVGCPKSCAVNKRRPECEECGGLGSPTGRCEWRQGDGKGITRNFSTCSPSTRTC 566
            .||                           .||:.||            |:        ||..|.
  Fly   412 GVT---------------------------NGGVSSP------------GV--------PSPGTG 429

  Rat   567 PDGHCDALESRDINICPQDCLRGPIVGGHERGERQGIKAGYGICNCFPDEKKCFCEPEDSQGPLC 631
            ..|.         |:.| .||.|   |....|..:         |.|..|..|
  Fly   430 EPGS---------NLGP-GCLTG---GAGSSGAPE---------NAFAGEANC------------ 460

  Rat   632 DELCRTVITAAVLFSFIISVLLSTFCIHRYHKHAHKPPIASAEMTFCRPAQGFPISYSSSGTRRP 696

  Fly   461 ----------------------------------------------------------------- 460

  Rat   697 SLDSMENQVSVDSFKIPEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFRLKGRAGYTTVAVKML 761
                               .:|||||..|.....||||.||:|.:..|..:.|..|.||||||.|
  Fly   461 -------------------DRWEFPRYRLKFFNILGEGAFGQVWRCEATNINGNEGITTVAVKTL 506

  Rat   762 KENASQSELRDLLSEFNLLKQVN-HPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRDSRKIGP 825
            ||:|::.:.:|||||..::|.:. |.:|:.|.|.|:...|..:|:||...|.|:.:||.||
  Fly   507 KESATEVDRKDLLSELEVMKSLEPHINVVHLLGCCTDKDPTFVILEYVNRGKLQTYLRSSR---- 567

  Rat   826 AYVSSGGSRNSSSLDHPDERVLTMGDLISFAWQISRGMQYLAEMKLVHRDLAARNILVAEGRKMK 890
                  ..|:..: .|....|||..||.||.:|:::||.||....::||||||||||:.:....|
  Fly   568 ------AERHYGN-THGKSNVLTSCDLTSFMYQVAKGMDYLTSRGIIHRDLAARNILITDDHTCK 625

  Rat   891 ISDFGLSRDVYEEDSYVKKSKGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPG 955
            ::|||.:|||.....|.:||:|::|::|||.|||:|:|::.:||:||||:|:|||||||..||||
  Fly   626 VADFGFARDVITSKIYERKSEGKLPIRWMATESLYDNIFSVKSDIWSFGILMWEIVTLGSTPYPG 690

  Rat   956 IPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKSRDYLDL 1019
            |....:...::.|:|:|:|::|..|:|.:|..||..:|.:||:||:|.:.|:|::....||::|
  Fly   691 ISAADVMRKVRDGYRLEKPEHCRRELYNIMYYCWSHDPQERPLFAEIIQMLDKLLHTEMDYIEL 754

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_036775.2	Cadherin	173..248	CDD:278457	15/81 (19%)
		PTKc_RET	724..1013	CDD:173631	123/289 (43%)
		Pkinase_Tyr	725..1006	CDD:285015	121/281 (43%)
		Inhibitors binding. /evidence=ECO:0000250	806..808		1/1 (100%)
Cad96Ca	NP_651349.1	Cadherin_repeat	65..164	CDD:206637	26/142 (18%)
		STYKc	470..741	CDD:214568	121/281 (43%)
		PTKc	474..742	CDD:270623	120/278 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810