Protein Alignment Ret and htl

DIOPT Version :9

• Sequence 1: NP_036775.2
• Gene: Ret / 24716
• RGDID: 3556
• Length: 1115
• Species: Rattus norvegicus
• Sequence 2: NP_524394.2
• Gene: htl / 42160
• FlyBaseID: FBgn0010389
• Length: 729
• Species: Drosophila melanogaster
• Alignment Length: 644
• Identity: 199/644 - (30%)
• Similarity: 289/644 - (44%)
• Gaps: 136/644 - (21%)

  Rat   517 PKSCAVNKRRPECE----ECGGLGSP--------TGRCEWRQGDGKGITRNFSTCSPSTRT---C 566
            ||..:..:.||...    .|..||:|        .|..:|.:|.| .:.||..|.:.....   |
  Fly   106 PKKMSFLQTRPSGSLLTLNCHALGNPEPNITWYRNGTVDWTRGYG-SLKRNRWTLTMEDLVPGDC 169

  Rat   567 PDGHCDALES-----RDINICPQD-------CLRGPI--------VGG-HER--GERQGIKAG-- 606
            .:..|....|     .|..:...|       .:.||:        .|. |.:  .:....||.
  Fly   170 GNYTCKVCNSLGCIRHDTQVIVSDRVNHKPILMTGPLNLTLVVNSTGSMHCKYLSDLTSKKAWIF 234

  Rat   607 ---YGICNCFPDEKKCFCEPED-----------------------------------------SQ 627
               :|:.|| .:.:....|.:|                                         ..
  Fly   235 VPCHGMTNC-SNNRSIIAEDKDQLDFVNVRMEQEGWYTCVESNSLGQSNSTAYLRVVRSLHVLEA 298

  Rat   628 GPLCDELCRTVITAAVLFSFIISVLLST-FCIHRYHKHAHKPPIA---------SAEMTFCRPAQ 682
            |.....|..|......:|..:|.:.::| |..:...|..|:..:.         :.::...:|..
  Fly   299 GVASGSLHSTSFVYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEG 363

  Rat   683 GFPISYSSSGTRRPSLDSMENQVSV----------DSFKIPEDPKWEFPRKNLVLGKTLGEGEFG 737
            |...|.|......|.:...:.:.:|          :.::.|.|..||.||.:||||.|||||.||
  Fly   364 GGDSSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFNEYEFPLDSNWELPRSHLVLGATLGEGAFG 428

  Rat   738 KVVKATAFRLKGRAGYTTVAVKMLKENASQSELRDLLSEFNLLKQV-NHPHVIKLYGACSQDGPL 801
            :||.|       ......|||||:||..:..::..|:.|..::|.: .|.::|.|.|.|||:|||
  Fly   429 RVVMA-------EVNNAIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPL 486

  Rat   802 LLIVEYAKYGSLRGFLRDSRKIGPAYVSSGGSRNSSS-LDHPDERVLTMGDLISFAWQISRGMQY 865
            .:|||||.:|:|:.||..:|..|     ....|:||. ...|...|:|..|||.||.||:|||.|
  Fly   487 YVIVEYAPHGNLKDFLYKNRPFG-----RDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDY 546

  Rat   866 LAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKKSKGRIPVKWMAIESLFDHIYT 930
            ||..:.:||||||||:||::...:||:||||:||:...|.|.|.:.||:|:||||.|||.:..|.
  Fly   547 LASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYD 611

  Rat   931 TQSDVWSFGVLLWEIVTLGGNPYPGI-PPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPD 994
            ::|||||:|:|||||:|.|..|||.| ..|.|:..|.:|.|||:|..||..:|.||.|||....|
  Fly   612 SKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNAD 676

  Rat   995 KRPVFADISKDLEKMMVKSRDYLDLAAS---TPSDSLLYDDGLSEEETPLVD-----CN 1045
            .||.|.:|.:.::|::....||||:..:   ||..:       |:||....|     ||
  Fly   677 DRPPFTEIVEYMDKLLQTKEDYLDVDIANLDTPPST-------SDEEEDETDNLQKWCN 728

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_036775.2	Cadherin	173..248	CDD:278457
		PTKc_RET	724..1013	CDD:173631	135/291 (46%)
		Pkinase_Tyr	725..1006	CDD:285015	134/283 (47%)
		Inhibitors binding. /evidence=ECO:0000250	806..808		1/1 (100%)
htl	NP_524394.2	Ig	112..191	CDD:299845	17/79 (22%)
		IG_like	113..191	CDD:214653	17/78 (22%)
		IG_like	205..289	CDD:214653	10/84 (12%)
		PKc_like	404..692	CDD:304357	141/299 (47%)
		STYKc	416..688	CDD:214568	134/283 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810