DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ren and CG6508

DIOPT Version :9

Sequence 1:	NP_036774.4	Gene:	Ren / 24715	RGDID:	3554	Length:	402	Species:	Rattus norvegicus
Sequence 2:	NP_609457.1	Gene:	CG6508 / 34493	FlyBaseID:	FBgn0032303	Length:	423	Species:	Drosophila melanogaster

Alignment Length:	405	Identity:	153/405 - (37%)
Similarity:	218/405 - (53%)	Gaps:	39/405 - (9%)

- Green bases have known domain annotations that are detailed below.

  Rat     6 MPLWALLLLWTSCSFSLPTDTASFGRILLKKMPSVREILEER-----GVDMTRISAEWGEFIKKS 65
            :||:.|||            ..|.|:  |::.|..|:|.:.:     ..:...::|::....::|
  Fly     9 IPLFLLLL------------DHSMGQ--LRRTPITRQINQNKTHANVKAEKILLAAKYFLVDRQS 59

  Rat    66 SFTNVTSPVVLTNYLDTQYYGEIGIGTPSQTFKVIFDTGSANLWVPSTKCGPLYTACEIHNLYDS 130
            |.|.    .||.|..:.:|...:.||||.|.|.:.|||||::|||||.||.....||:.||.|:|
  Fly    60 SQTT----QVLANGFNLEYTIRLCIGTPPQCFNLQFDTGSSDLWVPSVKCSSTNEACQKHNKYNS 120

  Rat   131 SESSSYMENGTEFTIHYGSGKVKGFLSQDVVTVGGIIV-TQTFGEVTELPLIPFMLAKFDGVLGM 194
            |.|||::|:|..|:|.||||.:.||||.|.|.:.|::: .|||.|..:.|...|:...|||::||
  Fly   121 SASSSHVEDGKGFSIQYGSGSLSGFLSTDTVDIDGMVIRNQTFAEAIDEPGSAFVNTIFDGIIGM 185

  Rat   195 GFPAQAVDGVIPVFDHILSQRVLKEEVFSVYYSRE-SHLLGGEVVLGGSDPQHYQGNFHYVSISK 258
            .| |....||...||:|:.|.::|..|||||..|: :...||||:.||.|...|:|..:||.:|.
  Fly   186 AF-ASISGGVTTPFDNIIRQGLVKHPVFSVYLRRDGTSQSGGEVIWGGIDRSIYRGCINYVPVSM 249

  Rat   259 AGSWQITMKGVSVGPATLLCEEGCMAVVDTGTSYISGPTSSLQLIMQALGVKEKRANNYVVNCSQ 323
            ...||.|...|.: ...||| .||.|:.|||||.|:.|..:.:.|.:.|...:.......|:||.
  Fly   250 PAYWQFTANSVKI-EGILLC-NGCQAIADTGTSLIAVPLRAYKAINKVLNATDAGDGEAFVDCSS 312

  Rat   324 VPTLPDISFYLGGRTYTLSNMDYVQK-NPFRNDDLCILA---LQGLDIPPPTGPVWVLGATFIRK 384
            :..||:::..:||.||||:..||:.| ....|..||:..   |||       ..:|:||..|:.|
  Fly   313 LCRLPNVNLNIGGTTYTLTPKDYIYKVQADNNQTLCLSGFTYLQG-------NLLWILGDIFLGK 370

  Rat   385 FYTEFDRHNNRIGFA 399
            .||.||....|||||
  Fly   371 VYTVFDVGKERIGFA 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ren	NP_036774.4	A1_Propeptide	31..64	CDD:400357	5/37 (14%)
Ren	NP_036774.4	renin_like	76..401	CDD:133154	137/330 (42%)
CG6508	NP_609457.1	pepsin_retropepsin_like	68..386	CDD:299705	136/328 (41%)
CG6508	NP_609457.1	Asp	73..387	CDD:278455	135/323 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344938
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.820