DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ren and Bace

DIOPT Version :9

Sequence 1:	NP_036774.4	Gene:	Ren / 24715	RGDID:	3554	Length:	402	Species:	Rattus norvegicus
Sequence 2:	NP_001285756.1	Gene:	Bace / 34182	FlyBaseID:	FBgn0032049	Length:	372	Species:	Drosophila melanogaster

Alignment Length:	368	Identity:	152/368 - (41%)
Similarity:	213/368 - (57%)	Gaps:	51/368 - (13%)

- Green bases have known domain annotations that are detailed below.

  Rat    36 KMPSVREILEERGVDMTRISAEWGEFIKKSSFTNVTSPVVLTNYLDTQYYGEIGIGTPSQTFKVI 100
            ::||:|.:.||:                            |:|.::..|||.|.||||:|:|||:
  Fly    49 QLPSLRSVDEEQ----------------------------LSNSMNMAYYGAISIGTPAQSFKVL 85

  Rat   101 FDTGSANLWVPSTKCGPLYTACEIHNLYDSSESSSYMENGTEFTIHYGSGKVKGFLSQDVVTVGG 165
            ||:||:||||||..|..  .||..||.||||.||:|:.||..|:|.||:|.:.|:||.|.|.|.|
  Fly    86 FDSGSSNLWVPSNTCKS--DACLTHNQYDSSASSTYVANGESFSIQYGTGSLTGYLSTDTVDVNG 148

  Rat   166 I-IVTQTFGEVTELPLIPFMLAKFDGVLGMGFPAQAVDGVIPVFDHILSQRVLKEEVFSVYYSRE 229
            : |.:|||.|.|..|...|..|.|||:|||.:.:.|||||.|.|.:::||.::...|||.|.:|:
  Fly   149 LSIQSQTFAESTNEPGTNFNDANFDGILGMAYESLAVDGVAPPFYNMVSQGLVDNSVFSFYLARD 213

  Rat   230 -SHLLGGEVVLGGSDPQHYQGNFHYVSISKAGSWQITMKGVSVGPATLLCEEGCMAVVDTGTSYI 293
             :..:|||::.||||...|.|...||.||:.|.||.||.|.|:...: ||:: |.|:.|||||.|
  Fly   214 GTSTMGGELIFGGSDASLYSGALTYVPISEQGYWQFTMAGSSIDGYS-LCDD-CQAIADTGTSLI 276

  Rat   294 SGPTSSLQLIMQALGVKEKRANNYVVNCSQVPTLPDISFYLGGRTYTLSNMDYVQKNPFRNDDLC 358
            ..|.::...:.:.|.|.|   :.| ::||.|.:|||::|.:||..:.|....|:    .::|..|
  Fly   277 VAPYNAYITLSEILNVGE---DGY-LDCSSVSSLPDVTFNIGGTNFVLKPSAYI----IQSDGNC 333

  Rat   359 ILALQ--GLDIPPPTGPVWVLGATFIRKFYTEFDRHNNRIGFA 399
            :.|.:  |.|.       |:||..||.::|||||..|||||||
  Fly   334 MSAFEYMGTDF-------WILGDVFIGQYYTEFDLGNNRIGFA 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ren	NP_036774.4	A1_Propeptide	31..64	CDD:400357	5/27 (19%)
Ren	NP_036774.4	renin_like	76..401	CDD:133154	147/328 (45%)
Bace	NP_001285756.1	pepsin_retropepsin_like	59..369	CDD:299705	146/356 (41%)
Bace	NP_001285756.1	Asp	68..371	CDD:278455	145/321 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344935
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.820