DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptprc and Ptp36E

DIOPT Version :9

Sequence 1:	NP_612516.2	Gene:	Ptprc / 24699	RGDID:	3451	Length:	1273	Species:	Rattus norvegicus
Sequence 2:	NP_001286033.1	Gene:	Ptp36E / 35091	FlyBaseID:	FBgn0267486	Length:	682	Species:	Drosophila melanogaster

Alignment Length:	649	Identity:	196/649 - (30%)
Similarity:	315/649 - (48%)	Gaps:	77/649 - (11%)

- Green bases have known domain annotations that are detailed below.

  Rat   583 EQQELVERDEEKQLINVDP-----IHSDLLLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKDAR 642
            |:.:|..|||...|....|     |...|.|...:||..   .|:..|||:..:|.|. ..:.|.
  Fly    61 ERIKLEARDENNSLSKTIPNGPIDIRHFLKLCDLRRKFP---VLYKLEFQTAAKVESN-TCRHAL 121

  Rat   643 KSQNQNKNRYVDILPYDYNRVELSEINGDAGSTYINASYIDGFKEPRKYIAAQGPRDETVDDFWK 707
            |..|..||:....:|||||||.|.::.|...|.|:||||:|...:|..||..|||.:|||..:|:
  Fly   122 KKNNLEKNQNPKCIPYDYNRVVLEKVGGLQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWR 186

  Rat   708 MIWEQKATVIVMVTRCEEGNRNKCAEYWPCMEEGTRTFRDVVVTINDHKRCPDYIIQ--KLSIAH 770
            |:|::..:.|||:|:..:..:..|.:|||...|....:.|:.:.|...::..::.|:  :|...:
  Fly   187 MVWQENISAIVMLTKTFDFAKVMCHQYWPPNMEVHEQYGDIFINIVREEQLANFHIRTFRLYKMN 251

  Rat   771 KKEKATG-REVTHIQFTSWPDHGVPEDPHLLLKLRRRVN-AFSNFFS------GPIVVHCSAGVG 827
            :|::.|. |.:....:|.|..|..|.. :.||:.||||. ...|...      |||:||||.|.|
  Fly   252 EKQEVTDERLILQFHYTEWYSHSCPFS-NALLEFRRRVRLVVGNIIKDEDDMRGPILVHCSDGGG 315

  Rat   828 RTGTYIGIDAMLESLEAEGKVDVYGYVVNLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLS 892
            |:|.|:.|||.||..|.|...:|:||:..||:.|..:|:...||..|:..|.|:...|:|...:|
  Fly   316 RSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEHIICGKTWFPVS 380

  Rat   893 ELHSCLQNLKKRDPPSDPSPLEAEYQRLPSYRSWRTQHI-------GNQEENKKKNRSSNVVPYD 950
            ||...|:...:|:..:..:..:|||.::..    :|...       |::.:|::|||....||.|
  Fly   381 ELSDRLKAKARRNSGTKMNEYQAEYDQICK----QTPRFTIGDCAGGHRADNREKNRDVLCVPPD 441

  Rat   951 FNRVPLKHELEMSKESEAESDESSDEDSDSEETSKYINASFVMSYWKPEMMIAAQGPLKETIGDF 1015
            ..|..|     .|.:..|.:|              |||:.||..|.||...|..:.|:|.|:|:|
  Fly   442 NFRPYL-----TSFQGNAFTD--------------YINSVFVDGYTKPREYIVTEWPMKHTLGEF 487

  Rat  1016 WQMIFQRKVKVIVMLTELMSGDQEVCAQYWGEGK-QTYGDM----EVMLKD-TN------KSSAY 1068
            |.:::.::...:|:|.:..|..|:..:.:..:.| :.||.:    .||.|. ||      |.:..
  Fly   488 WSLVYDQECSAVVVLCQPPSQSQQYPSFWPNKSKMEKYGPVFSVHYVMSKSYTNIKQWEFKINKK 552

  Rat  1069 ILRAFELRHSKRKEPRTVYQYQCTTW-KGEELPAEPKDLVTLIQNI---KQKLPKSGSEGMKYHK 1129
            |:...|:....:...|||..:|.|.| .|.::|:....||.|:..:   :.|:           .
  Fly   553 IVSLTEMMAGVKAPTRTVQLFQLTCWPMGHKVPSSTNSLVYLMNMVEIWRNKV-----------D 606

  Rat  1130 HASILVHCRDGSQQTGLFCALFNLLESAETEDVVDVFQVVKSLRKARPGMVGSFEQYQFLYDIM 1193
            :..:.|...||..:.|::||....:|.......|||||.||::|:.||.:|.:..:|::.||::
  Fly   607 YGPVCVVSPDGRSRAGVYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLV 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptprc	NP_612516.2	PTP_N	5..27	CDD:289238
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	45..192
		CD45	203..257	CDD:289344
		FN3	366..431	CDD:238020
		FN3	454..534	CDD:238020
		PTPc	621..880	CDD:214550	96/268 (36%)
		PTPc	649..880	CDD:238006	87/240 (36%)
		Substrate binding. /evidence=ECO:0000250	822..828		3/5 (60%)
		PTPc	913..1194	CDD:214550	80/304 (26%)
		PTPc	939..1194	CDD:238006	74/271 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	960..984		3/23 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1219..1273
Ptp36E	NP_001286033.1	Y_phosphatase	125..368	CDD:395053	88/243 (36%)
Ptp36E	NP_001286033.1	Y_phosphatase	428..671	CDD:395053	75/273 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4228
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	290	1.000	Inparanoid score	I2711
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.860