DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prkcg and Pkcdelta

DIOPT Version :9

Sequence 1:	NP_036760.1	Gene:	Prkcg / 24681	RGDID:	3397	Length:	697	Species:	Rattus norvegicus
Sequence 2:	NP_572797.3	Gene:	Pkcdelta / 32191	FlyBaseID:	FBgn0259680	Length:	1894	Species:	Drosophila melanogaster

Alignment Length:	540	Identity:	228/540 - (42%)
Similarity:	290/540 - (53%)	Gaps:	77/540 - (14%)

- Green bases have known domain annotations that are detailed below.

  Rat   193 DPYVKLKLIPDPRNLTKQKTKTVK----ATLNPVW-NETFVFNLKPGDVERRL------SVEVWD 246
            ||:.|:|:  |..|....|.:..:    ||..|:| .|..|::.:..|.|...      |::...
  Fly  1373 DPHKKIKI--DTTNKCYVKEEAPRYPLVATPRPLWKREKIVYSDENTDDESGSEEGSGGSLDEDS 1435

  Rat   247 WDRTSRNDFMGAMSFGVSELLKAPVDGWYKLLNQEEGEYYNVPVADADNCSLLQKFEACNYPLEL 311
            .|.:...:.....|...||.|.|..      :..:.|......|.|:.|.|      ..|.....
  Fly  1436 DDESGGEECSSTSSSASSEDLDAVA------MVTKAGSSNATTVLDSSNSS------GSNAGTLS 1488

  Rat   312 YERVRMGPSSSPIPSPSPSPTDSKRC-----FFG----ASPGRL--------------------- 346
            ......|.......|.|||......|     |.|    :||.::
  Fly  1489 VPSAGSGSGGGASTSSSPSIIRMSTCSNDSGFEGGTAPSSPKKMLETSYTYSQFQKSGRFTAPAT 1553

  Rat   347 --------HISDFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVL 403
                    .:.||.||.||||||||||:|||.|.:...||||.|||||:::|||||.||:|::||
  Fly  1554 VIPRFKNYSVDDFHFLAVLGKGSFGKVLLAELRDTTYYYAIKCLKKDVVLEDDDVDSTLIERKVL 1618

  Rat   404 ALGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEIAIGL 468
            |||.:.|     :|..|..||||...|:|||||:.|||||:|||:.|:|.|..|.||.|||..||
  Fly  1619 ALGTKHP-----YLCHLFCTFQTESHLFFVMEYLNGGDLMFHIQESGRFSEERARFYGAEIISGL 1678

  Rat   469 FFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGSTTRTFCGTPDYIAPEIIAYQPYG 533
            .|||.:||||||||||||:||.|||::|.||||||..::...|..:|||||||:|||||..:.|.
  Fly  1679 KFLHKKGIIYRDLKLDNVLLDYEGHVRIADFGMCKLQIYLDKTADSFCGTPDYMAPEIIKGEKYN 1743

  Rat   534 KSVDWWSFGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSREAVAICKGFLTKHPGKRL 598
            ::||||||||||||||.||.||.|.||:|||.:|..:...:|..:|.||..|.||.|.|...||:
  Fly  1744 QNVDWWSFGVLLYEMLIGQSPFSGCDEDELFWSICNEIPWFPVYISAEATGILKGLLEKDYTKRI 1808

  Rat   599 GS--GPDGEPTIRAHGFFRWIDWERLERLEIAPPFRPR---PCGRSGENFDKFFTRAAPALTPPD 658
            ||  .|.|:  |..|.|||.|||..||:.:|.|||:|:   |.  ..:.||:.|||....|||.|
  Fly  1809 GSQYSPAGD--IADHIFFRPIDWGLLEKRQIEPPFKPQVKHPL--DTQYFDRVFTRERVRLTPID 1869

  Rat   659 RLVLASIDQADFQGFTYVNP 678
            :.:|||:||..|.||||.||
  Fly  1870 KEILASMDQKQFHGFTYTNP 1889

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prkcg	NP_036760.1	C1_cPKC_rpt1	34..91	CDD:410383
		C1_cPKC_rpt2	101..154	CDD:410386
		C2_PKC_alpha_gamma	158..289	CDD:175992	23/106 (22%)
		STKc_cPKC	354..677	CDD:270739	185/327 (57%)
Pkcdelta	NP_572797.3	S_TKc	1566..1824	CDD:214567	154/264 (58%)
Pkcdelta	NP_572797.3	STKc_nPKC_theta_like	1570..1889	CDD:270744	184/327 (56%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343127
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D143719at33208
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X125
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850