DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prkar2b and Pka-R1

DIOPT Version :9

Sequence 1:	NP_001025191.1	Gene:	Prkar2b / 24679	RGDID:	3394	Length:	416	Species:	Rattus norvegicus
Sequence 2:	NP_001189150.1	Gene:	Pka-R1 / 40305	FlyBaseID:	FBgn0259243	Length:	464	Species:	Drosophila melanogaster

Alignment Length:	299	Identity:	125/299 - (41%)
Similarity:	179/299 - (59%)	Gaps:	17/299 - (5%)

- Green bases have known domain annotations that are detailed below.

  Rat   101 APVINRFTRRASVCAEAYNPDEEEDDAESRI--IHPKTDDQRNRLQEACKDILLFKNLDPEQMSQ 163
            ||.:.   ||..:.||...    |:||.:.:  :.||.....|.|.:|....:||.:||..:.|.
  Fly   173 APPVR---RRGGISAEPVT----EEDATNYVKKVVPKDYKTMNALSKAIAKNVLFAHLDESERSD 230

  Rat   164 VLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNT 228
            :.||||......||::|.|||:||||||||.|..|::|..:    .|......||||||||:|.|
  Fly   231 IFDAMFPVNHIAGENIIQQGDEGDNFYVIDVGEVDVFVNSE----LVTTISEGGSFGELALIYGT 291

  Rat   229 PRAATITATSPGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEVSERLKVVDVIGTK 293
            |||||:.|.:...|||:||.::|||::.:..:||||||.|:..:..|:||:..|||.|.|.:.|.
  Fly   292 PRAATVRAKTDVKLWGIDRDSYRRILMGSTIRKRKMYEEFLSRVSILESLDKWERLTVADSLETC 356

  Rat   294 VYNDGEQIIAQGDSADSFFIVESGEVRITMKRKGKSDIEENGAVEIARCLRGQYFGELALVTNKP 358
            .::|||.|:.||.:.|.|:|:..|...:..:|   |:..|:.| |:.|.....||||:||:.::|
  Fly   357 SFDDGETIVKQGAAGDDFYIILEGCAVVLQQR---SEQGEDPA-EVGRLGSSDYFGEIALLLDRP 417

  Rat   359 RAASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATY 397
            |||:..|.|.:||:.:|...|||:||||.:|:||||..|
  Fly   418 RAATVVARGPLKCVKLDRARFERVLGPCADILKRNITQY 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prkar2b	NP_001025191.1	Dimerization and phosphorylation	2..151		14/51 (27%)
		DD_RIIbeta_PKA	3..43	CDD:213051
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	53..97
		CAP_ED	152..265	CDD:237999	54/112 (48%)
		CAP_ED	274..394	CDD:237999	50/119 (42%)
Pka-R1	NP_001189150.1	Crp	213..>339	CDD:223736	59/129 (46%)
		CAP_ED	219..328	CDD:237999	54/112 (48%)
		Crp	331..>442	CDD:223736	44/114 (39%)
		CAP_ED	337..453	CDD:237999	50/119 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54324
OrthoDB	1	1.010	-	-		D1047290at2759
OrthoFinder	1	1.000	-	-		FOG0000531
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100449
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X421
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.730