Protein Alignment Ppp3ca and CanA1

DIOPT Version :9

• Sequence 1: NP_058737.1
• Gene: Ppp3ca / 24674
• RGDID: 3382
• Length: 521
• Species: Rattus norvegicus
• Sequence 2: NP_001247378.2
• Gene: CanA1 / 43670
• FlyBaseID: FBgn0010015
• Length: 622
• Species: Drosophila melanogaster
• Alignment Length: 538
• Identity: 373/538 - (69%)
• Similarity: 436/538 - (81%)
• Gaps: 42/538 - (7%)

  Rat    13 TTDRVVKAVPFPPSHRLTAKEVFDN--DGKPRVDILKAHLMKEGRLEESVALRIITEGASILRQE 75
            |.:|:|..||.||:|:||..||:|:  .|||..|.|:.|.:.|||:||:||||||||||::||:|
  Fly    51 TRERMVDDVPLPPTHKLTMSEVYDDPKTGKPNFDALRQHFLLEGRIEEAVALRIITEGAALLREE 115

  Rat    76 KNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILY 140
            ||::|::||:|||||||||||||:|||||||.||.||||||||||||||||||||||||:|||.|
  Fly   116 KNMIDVEAPITVCGDIHGQFFDLVKLFEVGGPPATTRYLFLGDYVDRGYFSIECVLYLWSLKITY 180

  Rat   141 PKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPE 205
            |.||.|||||||||||||||||||||.|||||.:|||||:||||||||||:||||||:|||||||
  Fly   181 PTTLSLLRGNHECRHLTEYFTFKQECIIKYSESIYDACMEAFDCLPLAALLNQQFLCIHGGLSPE 245

  Rat   206 INTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFGNEKTQEHFTHNTVRGCSYFYSYPAVCDFLQ 270
            |.|||||:.|:||:||||||||||:||||||||||||||.|.|:||:|||||||:||.|.|:|||
  Fly   246 IFTLDDIKTLNRFREPPAYGPMCDLLWSDPLEDFGNEKTNEFFSHNSVRGCSYFFSYSACCEFLQ 310

  Rat   271 HNNLLSILRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFN 335
            .||||||:|||||||||||||||:|.|||||||||||||||||||||||||||||||||||||||
  Fly   311 KNNLLSIVRAHEAQDAGYRMYRKNQVTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFN 375

  Rat   336 CSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDEL--GSEED---------------- 382
            ||||||||||||||||||||||||||||||||:|||||||||  |.:::
  Fly   376 CSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNILNICSDDELVAGPDDELEEELRKKIVLVPANA 440

  Rat   383 ----------GFDGATAAARKEVIRNKIRAIGKMARVFSVLREESESVLTLKGLTPTGMLPSGVL 437
                      ....:.:|.|||:|||||||||||:||||:|||||||||.||||||||.||.|.|
  Fly   441 SNNNNNNNTPSKPASMSALRKEIIRNKIRAIGKMSRVFSILREESESVLQLKGLTPTGALPVGAL 505

  Rat   438 SGGKQTLQSATVEAIEADEAIKGFSPQHKITSFEEAKGLDRINERMPPRRDAM--PSDANLNSIN 500
            |||:.:|:          ||::|.:....|.||.||||||.:||||||||..:  .|.:::.::.
  Fly   506 SGGRDSLK----------EALQGLTASSHIHSFAEAKGLDAVNERMPPRRPLLMSASSSSITTVT 560

  Rat   501 KALASETNGTDSNGSNSS 518
            ::.:|.:|..::|.:.||
  Fly   561 RSSSSSSNNNNNNSNTSS 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ppp3ca	NP_058737.1	MPP_PP2B	41..345	CDD:277361	254/303 (84%)
		Catalytic. /evidence=ECO:0000305	56..340		242/283 (86%)
		SAPNY motif. /evidence=ECO:0000250|UniProtKB:Q08209	307..311		3/3 (100%)
		Interaction with PxIxIF motif in substrate. /evidence=ECO:0000250|UniProtKB:Q08209	327..336		8/8 (100%)
		Calcineurin B binding. /evidence=ECO:0000250|UniProtKB:Q08209	341..369		27/27 (100%)
		Calmodulin-binding. /evidence=ECO:0000250|UniProtKB:Q08209	392..406		12/13 (92%)
		Autoinhibitory segment. /evidence=ECO:0000250|UniProtKB:P16298	407..414		4/6 (67%)
		Autoinhibitory domain. /evidence=ECO:0000269|PubMed:1322410	465..487		15/21 (71%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	475..521		17/46 (37%)
CanA1	NP_001247378.2	MPP_PP2B	81..385	CDD:277361	254/303 (84%)
		PP2Ac	98..369	CDD:197547	230/270 (85%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	92	1.000	Domainoid score	I7405
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53795
OrthoDB	1	1.010	-	-		D194337at33208
OrthoFinder	1	1.000	-	-		FOG0000983
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100566
Panther	1	1.100	-	-	O	PTHR45673
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X576
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.830