DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30495 and Wwox

DIOPT Version :9

Sequence 1:	NP_001260785.1	Gene:	CG30495 / 246651	FlyBaseID:	FBgn0050495	Length:	331	Species:	Drosophila melanogaster
Sequence 2:	NP_062519.2	Gene:	Wwox / 80707	MGIID:	1931237	Length:	414	Species:	Mus musculus

Alignment Length:	309	Identity:	121/309 - (39%)
Similarity:	171/309 - (55%)	Gaps:	37/309 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 MQGGKFRKQTDETGKVAIVTGGNTGLGKETVMELARRGATVYMACRNKEKVERARREIVKETGNS 96
            :||..|      ||||.:|||.|:|:|.||....|..||.|.:||||..:...|...|::|...:
Mouse   117 LQGRDF------TGKVVLVTGANSGIGFETAKSFALHGAHVILACRNLSRASEAVSRILEEWHKA 175

  Fly    97 NVFSRECDLSSLDSIRKFAENFKKEQRVLHILINNAGVFWEPHRLTKEGFEMHLGVNHIGHFLLT 161
            .|.:...||:.|.|::.|||.||.:...||:|:.|||.|..|..|||:|.|....|||:|||.|.
Mouse   176 KVEAMTLDLAVLRSVQHFAEAFKAKNVSLHVLVCNAGTFALPWGLTKDGLETTFQVNHLGHFYLV 240

  Fly   162 NLLLGVLERSAPSRVVVVASRAHERGQIKVDDINS--------------SDFYDEGVAYCQSKLA 212
            .||..||.||:|:||:||:|.:|     :..|||.              ||:: ..:||.:|||.
Mouse   241 QLLQDVLCRSSPARVIVVSSESH-----RFTDINDSSGKLDLSRLSPPRSDYW-AMLAYNRSKLC 299

  Fly   213 NILFTRELAKRLEGTGVTVNALNPG-IADTEIARNMIFFQTKFAQYVVETILRPLLWAVMKTPKN 276
            ||||:.||.:||...|||.||::|| :..:.|.||...::..|      |:.||.    .|:.:.
Mouse   300 NILFSNELHRRLSPRGVTSNAVHPGNMMYSAIHRNSWVYKLLF------TLARPF----TKSMQQ 354

  Fly   277 GAQTTLYAALDPDLERVSGQYFSDCALAPVAPAALDDQMAQWLWAQSEK 325
            ||.||:|.|:.|:||.:.|.||::|.....:..|..::.|:.||..||:
Mouse   355 GAATTVYCAVAPELEGLGGMYFNNCCRCLPSEEAQSEETARALWELSER 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30495	NP_001260785.1	FabG	44..296	CDD:223959	108/266 (41%)
CG30495	NP_001260785.1	NADB_Rossmann	45..323	CDD:304358	115/292 (39%)
Wwox	NP_062519.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		WW	19..47	CDD:238122
		Nuclear localization signal	50..55
		WW	60..90	CDD:238122
		PRK06196	107..404	CDD:235736	121/309 (39%)
		human_WWOX_like_SDR_c-like	124..407	CDD:187669	117/296 (40%)
		Interaction with MAPT. /evidence=ECO:0000269\|PubMed:15126504	125..414		116/295 (39%)
		Mediates targeting to the mitochondria	209..273		33/68 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1208
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000061
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100091
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X72
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.710