Protein Alignment CG30495 and HSD17B11

DIOPT Version :10

• Sequence 1: NP_001260785.1
• Gene: CG30495 / 246651
• FlyBaseID: FBgn0050495
• Length: 331
• Species: Drosophila melanogaster
• Sequence 2: NP_057329.3
• Gene: HSD17B11 / 51170
• HGNCID: 22960
• Length: 300
• Species: Homo sapiens
• Alignment Length: 302
• Identity: 82/302 - (27%)
• Similarity: 125/302 - (41%)
• Gaps: 54/302 - (17%)

  Fly     5 IRFLQSIAPVFLAHGIVGIIAFCVRLYMQGGKFRKQTDETGKVAIVTGGNTGLGKETVMELARRG 69
            ::||..|. :.|...||..:...|:|::.  |.||..  ||::.::||...|:|:.|..|.|:..
Human     1 MKFLLDIL-LLLPLLIVCSLESFVKLFIP--KRRKSV--TGEIVLITGAGHGIGRLTAYEFAKLK 60

  Fly    70 ATVYMACRNKEKVERARREIVKETGNSNVFSRECDLSSLDSIRKFAENFKKEQRVLHILINNAGV 134
            :.:.:...||..:|....: .|..| :.|.:...|.|:.:.|...|:..|.|...:.||:|||||
Human    61 SKLVLWDINKHGLEETAAK-CKGLG-AKVHTFVVDCSNREDIYSSAKKVKAEIGDVSILVNNAGV 123

  Fly   135 FWEPHRLTKEG--FEMHLGVNHIGHFLLTNLLLGVLERSAPSRVVVVASRAHERGQIKVDDINSS 197
            .:.......:.  .|....||.:.||..|...|..:.::....:|.|||.|   |.:.|..:
Human   124 VYTSDLFATQDPQIEKTFEVNVLAHFWTTKAFLPAMTKNNHGHIVTVASAA---GHVSVPFL--- 182

  Fly   198 DFYDEGVAYCQSKLANILF----TRELAKRLEGTGVTVNALNPGIADTEIARN------------ 246
                  :|||.||.|.:.|    |.||| .|:.|||....|.|...:|...:|
Human   183 ------LAYCSSKFAAVGFHKTLTDELA-ALQITGVKTTCLCPNFVNTGFIKNPSTSLGPTLEPE 240

  Fly   247 ---------------MIFFQTKFA-QYVVETILRPLLWAVMK 272
                           |||..:..| ...:|.||.....||:|
Human   241 EVVNRLMHGILTEQKMIFIPSSIAFLTTLERILPERFLAVLK 282

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG30495	NP_001260785.1	Rossmann-fold NAD(P)(+)-binding proteins	45..323	CDD:473865	70/262 (27%)
HSD17B11	NP_057329.3	17beta-HSDXI-like_SDR_c	38..277	CDD:187598	66/253 (26%)