DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30495 and RDH11

DIOPT Version :9

Sequence 1:	NP_001260785.1	Gene:	CG30495 / 246651	FlyBaseID:	FBgn0050495	Length:	331	Species:	Drosophila melanogaster
Sequence 2:	NP_057110.3	Gene:	RDH11 / 51109	HGNCID:	17964	Length:	318	Species:	Homo sapiens

Alignment Length:	303	Identity:	146/303 - (48%)
Similarity:	195/303 - (64%)	Gaps:	25/303 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 LYMQGGKFRKQTDE---------TGKVAIVTGGNTGLGKETVMELARRGATVYMACRNKEKVERA 85
            |||...:.||....         .|||.:|||.|||:||||..|||:|||.||:|||:.||.|..
Human    17 LYMAAPQIRKMLSSGVCTSTVQLPGKVVVVTGANTGIGKETAKELAQRGARVYLACRDVEKGELV 81

  Fly    86 RREIVKETGNSNVFSRECDLSSLDSIRKFAENFKKEQRVLHILINNAGVFWEPHRLTKEGFEMHL 150
            .:||...|||..|..|:.|||...|||.||:.|..|::.||:|||||||...|:..|.:|||||:
Human    82 AKEIQTTTGNQQVLVRKLDLSDTKSIRAFAKGFLAEEKHLHVLINNAGVMMCPYSKTADGFEMHI 146

  Fly   151 GVNHIGHFLLTNLLLGVLERSAPSRVVVVASRAHERGQIKVDDINSSDFYDEGVAYCQSKLANIL 215
            ||||:||||||:|||..|:.|||||:|.|:|.||..|:|...::....||:.|:|||.|||||||
Human   147 GVNHLGHFLLTHLLLEKLKESAPSRIVNVSSLAHHLGRIHFHNLQGEKFYNAGLAYCHSKLANIL 211

  Fly   216 FTRELAKRLEGTGVTVNALNPGIADTEIARNMIFFQTKFAQYVVETILRPLLWA---VMKTPKNG 277
            ||:|||:||:|:|||..:::||...:|:.|:..|             :|.:.|.   .:|||:.|
Human   212 FTQELARRLKGSGVTTYSVHPGTVQSELVRHSSF-------------MRWMWWLFSFFIKTPQQG 263

  Fly   278 AQTTLYAALDPDLERVSGQYFSDCALAPVAPAALDDQMAQWLW 320
            |||:|:.||...||.:||.:||||.:|.|:..|.::.:|:.||
Human   264 AQTSLHCALTEGLEILSGNHFSDCHVAWVSAQARNETIARRLW 306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30495	NP_001260785.1	FabG	44..296	CDD:223959	130/254 (51%)
CG30495	NP_001260785.1	NADB_Rossmann	45..323	CDD:304358	141/279 (51%)
RDH11	NP_057110.3	PRK06197	41..314	CDD:235737	141/279 (51%)
RDH11	NP_057110.3	NADB_Rossmann	41..309	CDD:304358	141/279 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1208
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H100724
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53570
OrthoDB	1	1.010	-	-		D414554at33208
OrthoFinder	1	1.000	-	-		FOG0000061
OrthoInspector	1	1.000	-	-		otm41333
orthoMCL	1	0.900	-	-		OOG6_100091
Panther	1	1.100	-	-	O	PTHR24320
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X72
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.790