DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30495 and wwox

DIOPT Version :9

Sequence 1:	NP_001260785.1	Gene:	CG30495 / 246651	FlyBaseID:	FBgn0050495	Length:	331	Species:	Drosophila melanogaster
Sequence 2:	NP_957207.1	Gene:	wwox / 393887	ZFINID:	ZDB-GENE-040426-858	Length:	412	Species:	Danio rerio

Alignment Length:	293	Identity:	114/293 - (38%)
Similarity:	166/293 - (56%)	Gaps:	19/293 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 DETGKVAIVTGGNTGLGKETVMELARRGATVYMACRNKEKVERARREIVKETGNSNVFSRECDLS 106
            |.:.||.||||.|:|:|.||....|..||.|.:||||:.:..:|...|:.|...:.|.....||:
Zfish   118 DLSDKVIIVTGANSGIGFETARSFALHGAHVILACRNQSRASKAASLIMGEWSKARVEVLPLDLA 182

  Fly   107 SLDSIRKFAENFKKEQRVLHILINNAGVFWEPHRLTKEGFEMHLGVNHIGHFLLTNLLLGVLERS 171
            ||.|:|:|||.||..:..||:|:.||.|..:|.|||::|||....:.|:|||||..||..||..|
Zfish   183 SLRSVRQFAELFKATKLPLHVLVCNAAVCSQPWRLTEDGFESTFQICHLGHFLLVQLLQDVLRLS 247

  Fly   172 APSRVVVVASRAHERGQIKVDDINSSDF---------YDEGVAYCQSKLANILFTRELAKRLEGT 227
            ||:|||||:|.:|....: :|...:.|.         |...:||.::||.|:||:.||.:|:...
Zfish   248 APARVVVVSSESHRFTDL-LDSCGNLDLDLLSPPQKNYWSLLAYNRAKLCNLLFSSELHRRMSPH 311

  Fly   228 GVTVNALNPGIADTEIARNMIFFQTKFAQYVVETILRPLLWAVMKTPKNGAQTTLYAALDPDLER 292
            |:..|||:||        :|:|.....:.::: |:|..|.....|:.:.||.||:|.|:.|:||.
Zfish   312 GICCNALHPG--------SMMFTSIHRSWWLL-TLLFSLARPFTKSMQQGAATTVYCAVAPELEG 367

  Fly   293 VSGQYFSDCALAPVAPAALDDQMAQWLWAQSEK 325
            :.|.||::|.....:|.|.|...|..||..||:
Zfish   368 IGGMYFNNCFRCLPSPQAQDPAAALSLWELSER 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30495	NP_001260785.1	FabG	44..296	CDD:223959	101/260 (39%)
CG30495	NP_001260785.1	NADB_Rossmann	45..323	CDD:304358	111/286 (39%)
wwox	NP_957207.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		WW	18..47	CDD:278809
		Nuclear localization signal. /evidence=ECO:0000250	50..55
		WW	59..88	CDD:278809
		PRK06196	108..402	CDD:235736	114/293 (39%)
		human_WWOX_like_SDR_c-like	121..404	CDD:187669	113/290 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000061
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100091
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X72
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810