Protein Alignment CG30495 and HSD17B1

DIOPT Version :10

• Sequence 1: NP_001260785.1
• Gene: CG30495 / 246651
• FlyBaseID: FBgn0050495
• Length: 331
• Species: Drosophila melanogaster
• Sequence 2: NP_001317148.1
• Gene: HSD17B1 / 3292
• HGNCID: 5210
• Length: 329
• Species: Homo sapiens
• Alignment Length: 296
• Identity: 65/296 - (21%)
• Similarity: 111/296 - (37%)
• Gaps: 58/296 - (19%)

  Fly    47 VAIVTGGNTGLGKETVMELA---RRGATVYMACRN---KEKVERARREIVKETGNSNVFSRECDL 105
            |.::||.::|:|....:.||   .:...||...|:   :.::..|.|.:.            |..
Human     5 VVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALA------------CPP 57

  Fly   106 SSLDSIRKFAENFKK----EQRV----LHILINNA--GVFWEPHRLTKEGFEMHLGVNHIGHFLL 160
            .||::::....:.|.    .:||    :.:|:.||  |:......|.::.....|.||.:|...:
Human    58 GSLETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRM 122

  Fly   161 TNLLLGVLERSAPSRVVVVASRAHERGQIKVDDINSSDFYDEGVAYCQSKLANILFTRELAKRLE 225
            ....|..::|....||:|..|         |..:....|.|   .||.||.|.......||..|.
Human   123 LQAFLPDMKRRGSGRVLVTGS---------VGGLMGLPFND---VYCASKFALEGLCESLAVLLL 175

  Fly   226 GTGVTVNAL---NP----------GIADTEIARNMIFFQTKFAQYVVETILRPLLWAVMKTPKNG 277
            ..||...:|   .|          |..:..:.|..|....:|.||:..:  :.:.....:.|:..
Human   176 PFGVHSLSLIECGPVHTAFMEKVLGSPEEVLDRTDIHTFHRFYQYLAHS--KQVFREAAQNPEEV 238

  Fly   278 AQTTLYAALDPDLERVSGQYFSDCALAPVAPAALDD 313
            |:..|.|...|   :.:.:||:.....|:....|||
Human   239 AEVFLTALRAP---KPTLRYFTTERFLPLLRMRLDD 271

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG30495	NP_001260785.1	Rossmann-fold NAD(P)(+)-binding proteins	45..323	CDD:473865	65/296 (22%)
HSD17B1	NP_001317148.1	Rossmann-fold NAD(P)(+)-binding proteins	4..262	CDD:473865	61/285 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	292..329