DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Coq9 and COQ9

DIOPT Version :9

Sequence 1:	NP_724594.1	Gene:	Coq9 / 246650	FlyBaseID:	FBgn0050493	Length:	326	Species:	Drosophila melanogaster
Sequence 2:	NP_064708.1	Gene:	COQ9 / 57017	HGNCID:	25302	Length:	318	Species:	Homo sapiens

Alignment Length:	313	Identity:	101/313 - (32%)
Similarity:	163/313 - (52%)	Gaps:	23/313 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 RLAPLQPRPLT----FLIARSYGKDEKKANLEDFRAREEQRER------ERDAADQAAEKASQKE 80
            ||..|:..|:.    .|:.|::     .|:....|:.:||:::      ::.:..|.|||...:.
Human    16 RLLQLRCLPVARCRQALVPRAF-----HASAVGLRSSDEQKQQPPNSFSQQHSETQGAEKPDPES 75

  Fly    81 AGGGGGLGAKGSESTGPEDDAKQAKVDAIRAKILDAALQHVPQQGWTRQAIILGAEESGYPSVVH 145
            :........:|.|.   |:|.:..  :.::.:||.|||:.||..|||.:||..||:..|..|...
Human    76 SHSPPRYTDQGGEE---EEDYESE--EQLQHRILTAALEFVPAHGWTAEAIAEGAQSLGLSSAAA 135

  Fly   146 GMFPEGGFALVSHFNGKCNAQL---VESLQQKTDGGKQEVEDPLDFLVQAVRQRLEMVTPYKTHW 207
            .||.:.|..|:.||..:||.:|   :|..|:....|:.|......||..||..||.|:.||..||
Human   136 SMFGKDGSELILHFVTQCNTRLTRVLEEEQKLVQLGQAEKRKTDQFLRDAVETRLRMLIPYIEHW 200

  Fly   208 PQAMALLAQPQHAPTALAQVLTLVDDICYYSGDRSVDFGWYTRRVGLATIMKMTELYFLQDKSPG 272
            |:|:::|..|.:.|::|:.:.::|||:.:|:||:|.||.|||||..||.|...|||..:||.||.
Human   201 PRALSILMLPHNIPSSLSLLTSMVDDMWHYAGDQSTDFNWYTRRAMLAAIYNTTELVMMQDSSPD 265

  Fly   273 HAQTWEFLKSRMDEAVQLQMMLSQTEGMTHTFQRSFNSAFITARNILGLGYNR 325
            ...||.||::|:::|:.:.....|.:.......:....|.:|.:|:.||...|
Human   266 FEDTWRFLENRVNDAMNMGHTAKQVKSTGEALVQGLMGAAVTLKNLTGLNQRR 318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Coq9	NP_724594.1	diverge_rpsU	110..297	CDD:274110	76/189 (40%)
Coq9	NP_724594.1	COQ9	217..287	CDD:285683	32/69 (46%)
COQ9	NP_064708.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	44..98		11/58 (19%)
		COQ9	102..281	CDD:419797	75/178 (42%)
		Lipid binding. /evidence=ECO:0000269\|PubMed:25339443, ECO:0007744\|PDB:4RHP	241..244		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147354
Domainoid	1	1.000	83	1.000	Domainoid score	I8373
eggNOG	1	0.900	-	-		E1_COG5590
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6477
Inparanoid	1	1.050	166	1.000	Inparanoid score	I4176
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55764
OrthoDB	1	1.010	-	-		D1304924at2759
OrthoFinder	1	1.000	-	-		FOG0006412
OrthoInspector	1	1.000	-	-		oto90027
orthoMCL	1	0.900	-	-		OOG6_104041
Panther	1	1.100	-	-	LDO	PTHR21427
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2073
SonicParanoid	1	1.000	-	-		X4676
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800