DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp12d1-p and cyp27a1.2

DIOPT Version :9

Sequence 1:	NP_001286304.1	Gene:	Cyp12d1-p / 246648	FlyBaseID:	FBgn0050489	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	XP_001334004.3	Gene:	cyp27a1.2 / 795106	ZFINID:	ZDB-GENE-081104-511	Length:	522	Species:	Danio rerio

Alignment Length:	538	Identity:	140/538 - (26%)
Similarity:	252/538 - (46%)	Gaps:	57/538 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LSSARSVA-IYVGPVRSS---RSASVLAHEQAKSSITEEH---KTYDEIPRPNKFKFMRAFMPGG 61
            ||||..:. .::.|..::   |||:..| ..|..|:.:.|   ||..::|....|..:...:..|
Zfish     7 LSSAERLGWCFLRPTAAATGFRSAAGNA-AAASVSVQDGHRKLKTEADLPEIKIFTMLYQMLFKG 70

  Fly    62 EFQNASITEYTSAMRKRYGDIYVMPGMFGRKDWVTTFNTKDIEMVFRNEGIWPRRDGLDSIVYFR 126
            ...  |:.|.....::.||.::.:..  |....::..:.:.:|.:.|.:..:|.|   ..:..:.
Zfish    71 YLN--SVHELQLYQKQVYGPLWKINA--GNLQGISISSVELLEELLRKDEKYPCR---GYMTLWT 128

  Fly   127 EHVRPDVYGEVQGLVASQNEAWGKLRSAINPIFMQPRGLRMYYEPLSNINNEFIERIKEIRD-PK 190
            ||  .|:.|...|....:.|.|.|||:.:|...:.|:....|.:.::.:..:||:||..:|: ..
Zfish   129 EH--RDLRGISYGPFTEEGEKWYKLRAVLNKRMLHPKDSVQYGDVVNAVITDFIKRIYYLREMSP 191

  Fly   191 TLEVPEDFTDEISRLVFESLGLVAFDRQMGLIRKNRDNSDALTLFQTSRDIFRLTFKLDIQPSMW 255
            |.::..:.|:|:.|...|.:..:.|:.::|.:.|... ::..........:|..:..:.:.|: |
Zfish   192 TGDLVSNLTNELYRFSLEGIASILFETRIGCLEKEIP-AETQKFINFIAQMFTYSMHVALLPN-W 254

  Fly   256 KIISTPTYRKMKRTLNDSLNVAQKMLKENQDALEKRRQ-----AGEKIN---SNSMLERLMEIDP 312
            .....|.::|.....:.......||:....:|::||..     |||.:.   ||..:.| .::..
Zfish   255 TRKYFPFWQKYIDGWDGIFKFGTKMIDMKMEAIQKRVDTNQDVAGEYLTYLLSNGKISR-KDVYG 318

  Fly   313 KVAVIMSLDILFAGVDATATLLSAVLLCLSKHPDKQAKLREELLSIMPTKDSLLNEENMKDMPYL 377
            .|:     ::|.||||:|:..:...|..|||.|:.|..|.:|:..:: ..|.:...|.:..||:|
Zfish   319 SVS-----ELLLAGVDSTSNTMLWALYLLSKDPEAQETLYQEVTKVL-KDDRIPTAEEVNSMPFL 377

  Fly   378 RAVIKETLRYYP-NGLGTMRTCQNDVILSGYRVPKGTTVLLGSNVLMKEATYYPRPDEFLPERWL 441
            :||||||||.|| ..:.:....:.:|::..|..||.||..|...|:.::...:|.|.:|.|||||
Zfish   378 KAVIKETLRLYPVVPVNSRLIAETEVVIGEYFFPKKTTFTLCHYVISRDEKVFPEPQKFKPERWL 442

  Fly   442 RDPETGKKMQVSPFTFLPFGFGPRMCIGKRVVDLEMETTVAKLIRNFHVEFNRDASRP------- 499
            ||..|    :.:||..:|||||.|.|:|:|:.:|||...:|:||:.|.:       ||
Zfish   443 RDGRT----RPNPFGSIPFGFGVRACVGRRIAELEMHLALARLIKLFEM-------RPDPTVGEV 496

  Fly   500 ---FKTMFVMEPAITFPF 514
               |:::.|....:...|
Zfish   497 KANFRSVLVPNKKVNLHF 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12d1-p	NP_001286304.1	p450	70..508	CDD:299894	121/457 (26%)
cyp27a1.2	XP_001334004.3	p450	66..505	CDD:278495	122/467 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	217	1.000	Domainoid score	I2609
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	219	1.000	Inparanoid score	I3547
OMA	1	1.010	-	-		QHG48087
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6352
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.880