DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp12d1-p and si:dkey-91i10.3

DIOPT Version :9

Sequence 1:	NP_001286304.1	Gene:	Cyp12d1-p / 246648	FlyBaseID:	FBgn0050489	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001116749.1	Gene:	si:dkey-91i10.3 / 565876	ZFINID:	ZDB-GENE-081105-124	Length:	513	Species:	Danio rerio

Alignment Length:	493	Identity:	127/493 - (25%)
Similarity:	239/493 - (48%)	Gaps:	32/493 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 EEHKTYDEIPRPNKFKFMRAFMPGGEFQNASITEYTSAMRKRYGDIY--VMPGMFGRKDWVTTFN 99
            ::.||.|::..|:....:......|.||.      |..|:..:..||  :....:|....|...:
Zfish    41 DKQKTMDDLDGPSFLTSLYWLFGKGYFQT------THQMQIEHSKIYGPLWKSKYGPLVIVNVAS 99

  Fly   100 TKDIEMVFRNEGIWPRRDGLDSIVYFREHVRPDVYGEVQGLVASQNEAWGKLRSAINPIFMQPRG 164
            ...||.|.|.||..|.|..:.....:|: :|...||.    :......|.::||.:||..::|:.
Zfish   100 ADLIEQVLRQEGRHPIRTDMPHWRGYRK-LRNHAYGP----LTEMGPEWQRIRSILNPRMLKPKH 159

  Fly   165 LRMYYEPLSNINNEFIERIKEIRDPKTLEV-PEDFTDEISRLVFESLGLVAFDRQMGLIRKNRDN 228
            :..|...::.:.::|||::.:::..|..:| ..|...|:.:..||.:..|.|:.:||.:......
Zfish   160 VSNYTNAINGVVSDFIEKMAKLKTTKGNDVMVYDVAGELYKFAFEGISSVLFETRMGCLNDEIPE 224

  Fly   229 SDALTLFQTSRDIFRLTFKLDIQPS-MWKIISTPTYRKMKRTLNDSLNVAQKMLKENQDALEKRR 292
            .....:|... ::|||:..:.:.|. :|..:  |.::......:....||.:::::....::::.
Zfish   225 ETQKFIFSVG-EMFRLSPIVILFPKFLWPYM--PFWKHFVAVWDHLFKVADELVQQKMTEIQEKV 286

  Fly   293 QAGEKINSNSMLERLMEIDPKVAVIMS--LDILFAGVDATATLLSAVLLCLSKHPDKQAKLREEL 355
            :.|..:....:...|:........::.  .::|.||||.|:..:|..|..|::.|:.|.||.||:
Zfish   287 KTGSPVEGEYLTHLLISEQMSFTEVLGSITELLLAGVDTTSNTISWALYHLAREPEIQQKLHEEV 351

  Fly   356 LSIMPTKDSLLNEENMKDMPYLRAVIKETLRYYPNGLGTMR-TCQNDVILSGYRVPKGTTVLLGS 419
            :|:.| .|...:.:::..||.|:|:::||||.||...|..| ..:|::::..:..||.|...|..
Zfish   352 VSVCP-GDKTPSSDDITRMPLLKAIVRETLRLYPVVPGNARVVAENEIVVGDHLFPKNTLFHLCH 415

  Fly   420 NVLMKEATYYPRPDEFLPERWLRDPETGKKMQVSPFTFLPFGFGPRMCIGKRVVDLEMETTVAKL 484
            ..:..:.|.:|.|..|||:||:|:.   |::...||..:|||||.|.|:|:||.:|||...:::|
Zfish   416 FAVSYDETVFPDPFAFLPQRWIREQ---KQLSQHPFGSVPFGFGIRACLGRRVAELEMYLLLSRL 477

  Fly   485 IRNFHVEFNRDAS----RPFKTMFVMEPAITFPFKFTD 518
            |:.:  |...|.|    :|. |..::.||.:...:|.|
Zfish   478 IKRY--EVRPDPSGKTVKPI-TRTLLVPATSIDLQFID 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12d1-p	NP_001286304.1	p450	70..508	CDD:299894	116/448 (26%)
si:dkey-91i10.3	NP_001116749.1	p450	52..510	CDD:278495	122/478 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	217	1.000	Domainoid score	I2609
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	219	1.000	Inparanoid score	I3547
OMA	1	1.010	-	-		QHG48087
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6352
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.880