DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp12d1-p and dib

DIOPT Version :9

Sequence 1:	NP_001286304.1	Gene:	Cyp12d1-p / 246648	FlyBaseID:	FBgn0050489	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_524810.2	Gene:	dib / 45282	FlyBaseID:	FBgn0000449	Length:	489	Species:	Drosophila melanogaster

Alignment Length:	491	Identity:	130/491 - (26%)
Similarity:	235/491 - (47%)	Gaps:	55/491 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 KTYDEIPRP-------NKFKFMRAFMPG-GEFQNASITEYTSAMRKRYGDIY---VMPGMFGRKD 93
            |.|..||.|       |.:.    ::|| |.:....:.:......::||.|.   ::||    :|
  Fly    19 KPYQAIPGPRGPFGMGNLYN----YLPGIGSYSWLRLHQAGQDKYEKYGAIVRETIVPG----QD 75

  Fly    94 WVTTFNTKDIEMVFRNEGIWPRRDGLDSIVYFREHVRPDVYGEVQGLVASQNEAWGKLRSAINPI 158
            .|..::.|||.::. ||...|:|....::..:|:. ||||| :..||:.:....|.::|:.:...
  Fly    76 IVWLYDPKDIALLL-NERDCPQRRSHLALAQYRKS-RPDVY-KTTGLLPTNGPEWWRIRAQVQKE 137

  Fly   159 FMQPRGLRMYYEPLSNINNEFIERIKEIRDPKTLEVPEDFTDEISRLVFESLGLVAFD-RQMGLI 222
            ...|:.:|.:...:..:..|||..::|.|:...:    |...:::||..|...|:.|. |.....
  Fly   138 LSAPKSVRNFVRQVDGVTKEFIRFLQESRNGGAI----DMLPKLTRLNLELTCLLTFGARLQSFT 198

  Fly   223 RKNRD-NSDALTLFQTSRDIFRLTFKLDIQPSMWKIISTPTYRKMKRTLNDSLNVAQKMLKENQD 286
            .:.:| .|.:..|...:..........|....:|:.:.||::||:.:..:...:||.::::||
  Fly   199 AQEQDPRSRSTRLMDAAETTNSCILPTDQGLQLWRFLETPSFRKLSQAQSYMESVALELVEEN-- 261

  Fly   287 ALEKRRQAGEKINSNSMLERLM-------EIDPKVAVIMSLDILFAGVDATATLLSAVLLCLSKH 344
                       :.:.|:...|:       |:|....|..:.|:|.||:|.|:...:.:|..::::
  Fly   262 -----------VRNGSVGSSLISAYVKNPELDRSDVVGTAADLLLAGIDTTSYASAFLLYHIARN 315

  Fly   345 PDKQAKLREELLSIMPT-KDSLLNEENMKDMPYLRAVIKETLRYYPNGLGTMRTCQNDVILSGYR 408
            |:.|.||.||...::|: ||.|..:....|:.|.|||:||:||..|..:|..|....|.|.|||.
  Fly   316 PEVQQKLHEEARRVLPSAKDELSMDALRTDITYTRAVLKESLRLNPIAVGVGRILNQDAIFSGYF 380

  Fly   409 VPKGTTVLLGSNVLMKEATYYPRPDEFLPERWLRDPETGKKMQVSPFTFLPFGFGPRMCIGKRVV 473
            |||||||:..:.|..:...::..|..|.|:|||:     .:..::|:..||||.|.|.||.:|:.
  Fly   381 VPKGTTVVTQNMVACRLEQHFQDPLRFQPDRWLQ-----HRSALNPYLVLPFGHGMRACIARRLA 440

  Fly   474 DLEMETTVAKLIRNFHVEFN-RDASRPFKTMFVMEP 508
            :..|...:.:|:|.:.:.:: .|.....||:.:.:|
  Fly   441 EQNMHILLLRLLREYELIWSGSDDEMGVKTLLINKP 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12d1-p	NP_001286304.1	p450	70..508	CDD:299894	120/451 (27%)
dib	NP_524810.2	p450	25..446	CDD:299894	121/453 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	1	1.000	-	-		FOG0000720
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24305
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
	6	5.920