DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp12d1-p and cyp27a7

DIOPT Version :9

Sequence 1:	NP_001286304.1	Gene:	Cyp12d1-p / 246648	FlyBaseID:	FBgn0050489	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	XP_002663445.1	Gene:	cyp27a7 / 402831	ZFINID:	ZDB-GENE-081104-519	Length:	524	Species:	Danio rerio

Alignment Length:	524	Identity:	141/524 - (26%)
Similarity:	245/524 - (46%)	Gaps:	59/524 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LSSARSVAIYVGPVRSSRSASVLAH-----EQAKSSITEEH---KTYDEIPRPNKFKFMRAFMPG 60
            ||||..:.|.:|.:|.:.:|:....     ..|..|:.:.|   ||..::|....|..:...:..
Zfish     7 LSSAERLGIGLGFLRPTAAATGFRRAAGNAAAASVSVQDGHRKLKTEADLPEIKIFTMLYRLLFK 71

  Fly    61 GEFQNASITEYTSAM-------RKRYGDIY-VMPGMFGRKDWVTTFNTKD-IEMVFRNEGIWPRR 116
            |         |.|.|       ::.||.:| :..|.|..    ...|:.| :|.:.|.:..:|.|
Zfish    72 G---------YLSRMHELQLYEKQLYGPLYKINVGNFQS----VALNSVDLLEELLRKDEKFPSR 123

  Fly   117 DGLDSIVYFREHVRPDVYGEVQGLVASQNEAWGKLRSAINPIFMQPRGLRMYYEPLSNINNEFIE 181
            ..:.....:|     |:.|...|....:.|.|.|||:.:|...:.|:....|.:.::.:..:||:
Zfish   124 GDMTLWTEYR-----DMKGIGYGPFTEEGEKWYKLRAVLNKRMLHPKDSVQYGDVVNAVITDFIK 183

  Fly   182 RIKEIRD-PKTLEVPEDFTDEISRLVFESLGLVAFDRQMGLIRKNRDNSDALTLFQTSRDIFRLT 245
            ||..:|: ..|.::..:.|:|:.|...|.:..:.|:.::|.:.|   ...|.|....:.....||
Zfish   184 RIYYLREMSPTGDLVSNLTNELYRFSLEGISSILFETRIGCLEK---EIPAETQHFINSIAQMLT 245

  Fly   246 FKLDI--QPSMWKIISTPTYRKMKRTLNDSLNVAQKMLKENQDALEKRRQAGEKINSNSMLERLM 308
            :.:.:  .|: |.....|.:::.....:.....|.||:....:||:||..|.::: :...|..|:
Zfish   246 YSMPVVFMPN-WTRNYLPFWQRYIGGWDGIFKFAGKMIDMKMEALQKRVDANQEV-AGEYLTYLL 308

  Fly   309 ---EIDPKVAVIMSLDILFAGVDATATLLSAVLLCLSKHPDKQAKLREELLSIMPTKDSLLNEEN 370
               ::..|.......::|.||||.|:..:...|..|||.|:.|..|.:|:.::: ..|.:...:.
Zfish   309 SNGKMSSKDVYGSVSELLLAGVDTTSNTMLFALYHLSKDPETQDILYQEVTNVL-KDDRIPTAQE 372

  Fly   371 MKDMPYLRAVIKETLRYYP-NGLGTMRTCQNDVILSGYRVPKGTTVLLGSNVLMKEATYYPRPDE 434
            :..|.||:||||||||.|| ..:......:|:|::.|:..||.||..|....:.::...:|.|.:
Zfish   373 VNTMSYLKAVIKETLRLYPVVPMNARLIAENEVVIGGHLFPKNTTFTLCHYAISRDEKVFPEPQK 437

  Fly   435 FLPERWLRDPETGKKMQVSPFTFLPFGFGPRMCIGKRVVDLEMETTVAKLIRNFHVEFNRDASRP 499
            |.|||||||..|    :.:||..:|||||.|.|:|:|:.:|||...:|:||:.|.:       ||
Zfish   438 FKPERWLRDGRT----RPNPFGSIPFGFGVRGCVGRRIAELEMYLALARLIKLFEI-------RP 491

  Fly   500 FKTM 503
            ..|:
Zfish   492 DPTV 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12d1-p	NP_001286304.1	p450	70..508	CDD:299894	125/450 (28%)
cyp27a7	XP_002663445.1	p450	68..507	CDD:278495	126/463 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	217	1.000	Domainoid score	I2609
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	219	1.000	Inparanoid score	I3547
OMA	1	1.010	-	-		QHG48087
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6352
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.880