Protein Alignment Cyp12d1-p and cyp27a1.1

DIOPT Version :10

• Sequence 1: NP_610635.4
• Gene: Cyp12d1-p / 246648
• FlyBaseID: FBgn0050489
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: XP_002663445.1
• Gene: cyp27a1.1 / 402831
• ZFINID: ZDB-GENE-081104-519
• Length: 524
• Species: Danio rerio
• Alignment Length: 524
• Identity: 141/524 - (26%)
• Similarity: 245/524 - (46%)
• Gaps: 59/524 - (11%)

  Fly     4 LSSARSVAIYVGPVRSSRSASVLAH-----EQAKSSITEEH---KTYDEIPRPNKFKFMRAFMPG 60
            ||||..:.|.:|.:|.:.:|:....     ..|..|:.:.|   ||..::|....|..:...:..
Zfish     7 LSSAERLGIGLGFLRPTAAATGFRRAAGNAAAASVSVQDGHRKLKTEADLPEIKIFTMLYRLLFK 71

  Fly    61 GEFQNASITEYTSAM-------RKRYGDIY-VMPGMFGRKDWVTTFNTKD-IEMVFRNEGIWPRR 116
            |         |.|.|       ::.||.:| :..|.|..    ...|:.| :|.:.|.:..:|.|
Zfish    72 G---------YLSRMHELQLYEKQLYGPLYKINVGNFQS----VALNSVDLLEELLRKDEKFPSR 123

  Fly   117 DGLDSIVYFREHVRPDVYGEVQGLVASQNEAWGKLRSAINPIFMQPRGLRMYYEPLSNINNEFIE 181
            ..:.....:|     |:.|...|....:.|.|.|||:.:|...:.|:....|.:.::.:..:||:
Zfish   124 GDMTLWTEYR-----DMKGIGYGPFTEEGEKWYKLRAVLNKRMLHPKDSVQYGDVVNAVITDFIK 183

  Fly   182 RIKEIRD-PKTLEVPEDFTDEISRLVFESLGLVAFDRQMGLIRKNRDNSDALTLFQTSRDIFRLT 245
            ||..:|: ..|.::..:.|:|:.|...|.:..:.|:.::|.:.|   ...|.|....:.....||
Zfish   184 RIYYLREMSPTGDLVSNLTNELYRFSLEGISSILFETRIGCLEK---EIPAETQHFINSIAQMLT 245

  Fly   246 FKLDI--QPSMWKIISTPTYRKMKRTLNDSLNVAQKMLKENQDALEKRRQAGEKINSNSMLERLM 308
            :.:.:  .|: |.....|.:::.....:.....|.||:....:||:||..|.::: :...|..|:
Zfish   246 YSMPVVFMPN-WTRNYLPFWQRYIGGWDGIFKFAGKMIDMKMEALQKRVDANQEV-AGEYLTYLL 308

  Fly   309 ---EIDPKVAVIMSLDILFAGVDATATLLSAVLLCLSKHPDKQAKLREELLSIMPTKDSLLNEEN 370
               ::..|.......::|.||||.|:..:...|..|||.|:.|..|.:|:.::: ..|.:...:.
Zfish   309 SNGKMSSKDVYGSVSELLLAGVDTTSNTMLFALYHLSKDPETQDILYQEVTNVL-KDDRIPTAQE 372

  Fly   371 MKDMPYLRAVIKETLRYYP-NGLGTMRTCQNDVILSGYRVPKGTTVLLGSNVLMKEATYYPRPDE 434
            :..|.||:||||||||.|| ..:......:|:|::.|:..||.||..|....:.::...:|.|.:
Zfish   373 VNTMSYLKAVIKETLRLYPVVPMNARLIAENEVVIGGHLFPKNTTFTLCHYAISRDEKVFPEPQK 437

  Fly   435 FLPERWLRDPETGKKMQVSPFTFLPFGFGPRMCIGKRVVDLEMETTVAKLIRNFHVEFNRDASRP 499
            |.|||||||..|    :.:||..:|||||.|.|:|:|:.:|||...:|:||:.|.:       ||
Zfish   438 FKPERWLRDGRT----RPNPFGSIPFGFGVRGCVGRRIAELEMYLALARLIKLFEI-------RP 491

  Fly   500 FKTM 503
            ..|:
Zfish   492 DPTV 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12d1-p	NP_610635.4	CYP24A1-like	76..508	CDD:410677	122/437 (28%)
cyp27a1.1	XP_002663445.1	cytochrome_P450	85..514	CDD:477761	122/437 (28%)