DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp12d1-p and Cyp4d21

DIOPT Version :9

Sequence 1:	NP_001286304.1	Gene:	Cyp12d1-p / 246648	FlyBaseID:	FBgn0050489	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_609129.2	Gene:	Cyp4d21 / 34036	FlyBaseID:	FBgn0031925	Length:	511	Species:	Drosophila melanogaster

Alignment Length:	480	Identity:	121/480 - (25%)
Similarity:	218/480 - (45%)	Gaps:	60/480 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 RPNKFKFMRAFMP------GGEFQNASITEYTSAMRKRYGDIYVMPGMFGR--KDWV---TTFNT 100
            |.|.|:..|...|      |...|  ::|.......:|:||.:   ..:|:  :.|:   ....|
  Fly    24 RVNTFEKSRILGPFTIPIVGNGLQ--ALTLRPENFIQRFGDYF---NKYGKTFRLWILGECLIYT 83

  Fly   101 KDIEMVFRNEGIWPRRDGLDSIVYFREHVRPDVYGEVQGLVASQNEAWGKLRSAINPIFMQPRGL 165
            ||::..   |.|......|.....:| .:| |..|:  ||:.|....|...|..:.|.| ..:.|
  Fly    84 KDLKYF---ESILSSSTLLKKAHLYR-FLR-DFLGD--GLLLSTGNKWTSRRKVLAPAF-HFKCL 140

  Fly   166 RMYYEPLSNINNEFIERIKEIRDPKTLEVPEDFTDEISRLVFESLGLVAFDRQMGLIRKNRDNSD 230
            ..:.|.:...:...:|::|...|.||.      .|....:..|:|. |..:..|| ::.|..|..
  Fly   141 ENFVEIMDRNSGIMVEKLKNYADGKTC------VDLFKFVSLEALD-VTTETAMG-VQVNAQNEP 197

  Fly   231 ALTLFQTSRDIFRLTFKLDIQPSM---WKI-ISTP-TYRKMKRTLNDSLNVAQKMLKENQDALEK 290
            .....:..:.:..:..|.....||   |.. ::.| .||::::.:....:...|:::|.:..||:
  Fly   198 NFPYTKALKSVVYIESKRLASVSMRYNWLFPLAAPLVYRRLQKDIAIMQDFTDKVIRERRAILER 262

  Fly   291 RRQAG---------EKINSN---SMLERLME--IDPK----VAVIMSLDI-LFAGVDATATLLSA 336
            .|..|         :.|...   ::|:.|::  ||.|    |.:...:|: :|||.|.|.:.:|.
  Fly   263 ARADGTYKPLIMGDDDIGGKAKMTLLDILLQATIDNKPLSDVDIREEVDVFIFAGDDTTTSGVSH 327

  Fly   337 VLLCLSKHPDKQAKLREELLSIM-PTKDSLLNEENMKDMPYLRAVIKETLRYYPNGLGTMRTCQN 400
            .|..:|:||..|..:.|||:|:: |..|:.:.:..:.::.||..|||||:|.:|......|....
  Fly   328 ALHAISRHPKVQECIYEELVSVLGPDPDASVTQTKLLELKYLDCVIKETMRLHPPVPILGRYIPE 392

  Fly   401 DVILSGYRVPKGTTVLLGSNVLMKEATYYPRPDEFLPERWLRDPETGKKMQVSPFTFLPFGFGPR 465
            |:.:....:|..|::||....:.::..|:|.|..|.||||: |.:|  .....|..::||..||:
  Fly   393 DLKIGEITIPGNTSILLMPYYVYRDPEYFPDPLVFKPERWM-DMKT--TSNTPPLAYIPFSSGPK 454

  Fly   466 MCIGKRVVDLEMETTVAKLIRNFHV 490
            .|||::..:|:|:..::|:||::.:
  Fly   455 NCIGQKFANLQMKALISKVIRHYEL 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12d1-p	NP_001286304.1	p450	70..508	CDD:299894	113/451 (25%)
Cyp4d21	NP_609129.2	p450	35..482	CDD:278495	117/469 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D825914at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.920