DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp12d1-p and cyp27a1.4

DIOPT Version :9

Sequence 1:	NP_001286304.1	Gene:	Cyp12d1-p / 246648	FlyBaseID:	FBgn0050489	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001315442.1	Gene:	cyp27a1.4 / 322341	ZFINID:	ZDB-GENE-030131-1060	Length:	522	Species:	Danio rerio

Alignment Length:	532	Identity:	131/532 - (24%)
Similarity:	243/532 - (45%)	Gaps:	45/532 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LSSARSVA-IYVGPVRSSRSASVLAHEQAKSSITEEH-----KTYDEIPRPNKFKFMRAFMPGGE 62
            ||||..:. .::.|..::......|...|.:|::.:.     ||..::|....|..:...:..|.
Zfish     7 LSSAERLGWCFLRPTTAATGFRRAAGNSAAASVSVQDGHRKLKTEADLPEIKIFTMLYQMLFKGY 71

  Fly    63 FQNASITEYTSAMRKRYGDIYVMPGMFGRKDWVTTFNTKDIEMVFRNEGIWPRRDGLDSIVYFRE 127
            ..  |:.|.....::.||.::.:..  |....::..:.:.:|.:.|.:..:|.|   ..:..:.|
Zfish    72 LN--SVHELQLYQKQVYGPLWKINA--GNLQGISITSVELLEELLRKDEKYPCR---GYMTLWTE 129

  Fly   128 HVRPDVYGEVQGLVASQNEAWGKLRSAINPIFMQPRGLRMYYEPLSNINNEFIERIKEIRD-PKT 191
            |  .|:.|...|....:.|.|.|||:.:|...:.|:....|.:.::.:..:||:||..:|: ..|
Zfish   130 H--RDLRGISYGPFTEEGEKWYKLRAVLNKRMLHPKDSLQYGDVVNAVITDFIKRIYYLREMSPT 192

  Fly   192 LEVPEDFTDEISRLVFESLGLVAFDRQMGLIRKNRDNSDALTLFQTSRDIFRLTFKLDIQPSMWK 256
            .::..:.|:|:.|...|.:..:.|:.::|.:.|... ::......:...:|.....:.:.|: |.
Zfish   193 GDLVSNLTNELYRFSLEGIASILFETRIGCLEKEIP-AETQEFINSIAQMFTYNMHVALLPN-WT 255

  Fly   257 IISTPTYRKMKRTLNDSLNVAQKMLKENQDALEKRRQAGEKINSNSMLERLM---EIDPKVAVIM 318
            ....|.::|.....:.......||:....:|::.|....::: :...|..|:   ::..|.....
Zfish   256 RNYLPFWQKYIDGWDGIFKFGTKMINLKMEAIQTRLDTNQEV-AGEYLTYLLSSGKMSCKDVYGS 319

  Fly   319 SLDILFAGVDATATLLSAVLLCLSKHPDKQAKLREELLSIMPTKDSLLNEENMKDMPYLRAVIKE 383
            ..::|.||||.|:..:...|..|||.|..|..|.:|:..:: ..|.:...|.:..||:|:|||||
Zfish   320 VSEVLLAGVDTTSNTMLWALYLLSKDPAAQETLHQEVTKVL-KGDRIPTAEEVNSMPFLKAVIKE 383

  Fly   384 TLRYYP-NGLGTMRTCQNDVILSGYRVPKGTTVLLGSNVLMKEATYYPRPDEFLPERWLRDPETG 447
            |||.|| ..:.:....:::||:..|..||.||..|....:..:...:|.|.:|.|||||||..|
Zfish   384 TLRLYPVVPVNSRLIAESEVIIGEYLFPKKTTFNLFHYAISHDEKVFPEPQKFKPERWLRDGRT- 447

  Fly   448 KKMQVSPFTFLPFGFGPRMCIGKRVVDLEMETTVAKLIRNFHVEFNRDASRP----------FKT 502
               :.:||..:|||||.|.|:|:|:.:|||...:|:||:.|.:       ||          |::
Zfish   448 ---RPNPFGSIPFGFGVRACVGRRIAELEMHLALARLIKLFEM-------RPDPTVGEVKANFRS 502

  Fly   503 MFVMEPAITFPF 514
            :.|....:...|
Zfish   503 VLVPNKKVNLHF 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12d1-p	NP_001286304.1	p450	70..508	CDD:299894	116/452 (26%)
cyp27a1.4	NP_001315442.1	p450	66..505	CDD:278495	117/462 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	217	1.000	Domainoid score	I2609
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	219	1.000	Inparanoid score	I3547
OMA	1	1.010	-	-		QHG48087
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6352
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.880