Protein Alignment Cyp12d1-p and Cyp27a1

DIOPT Version :10

• Sequence 1: NP_610635.4
• Gene: Cyp12d1-p / 246648
• FlyBaseID: FBgn0050489
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_849178.2
• Gene: Cyp27a1 / 301517
• RGDID: 727915
• Length: 533
• Species: Rattus norvegicus
• Alignment Length: 493
• Identity: 130/493 - (26%)
• Similarity: 239/493 - (48%)
• Gaps: 51/493 - (10%)

  Fly    23 ASVLAHEQAKSSITEEH----KTYDEIPRPNKFKFM-RAFMPGGEFQNASITEYTSAMRKRYGDI 82
            |::..||..:...|.:.    ::..|:|.|...:|: :.|:.|....   :.|..:..:.:||.:
  Rat    36 AALRDHESTEGPGTGQDRPRLRSLAELPGPGTLRFLFQLFLRGYVLH---LHELQALNKAKYGPM 97

  Fly    83 YVMPGMFGRKDWVTTFNTKD---------IEMVFRNEGIWPRRDGLDSIVYFREHVRPDVYGEVQ 138
                       |.|||.|:.         :|.|.|.||.:|.||.::.   ::||  .|..|...
  Rat    98 -----------WTTTFGTRTNVNLASAPLLEQVMRQEGKYPIRDSMEQ---WKEH--RDHKGLSY 146

  Fly   139 GLVASQNEAWGKLRSAINPIFMQPRGLRMYYEPLSNINNEFIERIKEIRDPKTL--EVPEDFTDE 201
            |:..:|.:.|..||.::|...::|....:|.:.|:.:.::||.|:.::|.....  :|| |....
  Rat   147 GIFITQGQQWYHLRHSLNQRMLKPAEAALYTDALNEVISDFIARLDQVRTESASGDQVP-DVAHL 210

  Fly   202 ISRLVFESLGLVAFDRQMGLIRKNRDNSDALTLFQTSRDIFRLTFKLDIQPSMWKIISTPTYRKM 266
            :..|..|::..:.|::::|.:..:.. .|..|..::...:|:.:..:...|. |   |.|.....
  Rat   211 LYHLALEAICYILFEKRVGCLEPSIP-EDTATFIRSVGLMFKNSVYVTFLPK-W---SRPLLPFW 270

  Fly   267 KRTLNDSLNV---AQKMLKENQDALEKRRQAG--EKINSNSMLERLME---IDPKVAVIMSLDIL 323
            ||.:|:..|:   .:||:.:....:|.:.||.  :.:..:..|..|:.   :.|:..|....:::
  Rat   271 KRYMNNWDNIFSFGEKMIHQKVQEIEAQLQAAGPDGVQVSGYLHFLLTKELLSPQETVGTFPELI 335

  Fly   324 FAGVDATATLLSAVLLCLSKHPDKQAKLREELLSIMPTKDSLLNEENMKDMPYLRAVIKETLRYY 388
            .||||.|:..|:..|..|||:|:.|..|.:|:..::|. ..:...::...||.|:||||||||.|
  Rat   336 LAGVDTTSNTLTWALYHLSKNPEIQEALHKEVTGVVPF-GKVPQNKDFAHMPLLKAVIKETLRLY 399

  Fly   389 PNGLGTMR-TCQNDVILSGYRVPKGTTVLLGSNVLMKEATYYPRPDEFLPERWLRDPETGKKMQV 452
            |......| ..:.:..::|:..||.|..:|...|:.::.:.:|.|:.|.|.||||..|.......
  Rat   400 PVVPTNSRIITEKETEINGFLFPKNTQFVLCHYVVSRDPSVFPEPESFQPHRWLRKREDDNSGIQ 464

  Fly   453 SPFTFLPFGFGPRMCIGKRVVDLEMETTVAKLIRNFHV 490
            .||..:|||:|.|.|:|:|:.:|||:..:::||:.:.|
  Rat   465 HPFGSVPFGYGVRSCLGRRIAELEMQLLLSRLIQKYEV 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12d1-p	NP_610635.4	CYP24A1-like	76..508	CDD:410677	119/435 (27%)
Cyp27a1	NP_849178.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	38..58		3/19 (16%)
		cytochrome_P450	91..527	CDD:477761	119/435 (27%)
		Sterol-binding. /evidence=ECO:0000255	386..400		10/13 (77%)