DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp12d1-p and Cyp24a1

DIOPT Version :9

Sequence 1:	NP_001286304.1	Gene:	Cyp12d1-p / 246648	FlyBaseID:	FBgn0050489	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_963966.1	Gene:	Cyp24a1 / 25279	RGDID:	2462	Length:	514	Species:	Rattus norvegicus

Alignment Length:	515	Identity:	136/515 - (26%)
Similarity:	248/515 - (48%)	Gaps:	46/515 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 VRSSRSASVLAHEQAKSSITEEHKTYD--EIPRPNKF----KFMRAFMPGG-EFQNASITEYTSA 74
            |.|..|||....|.....:..:.:|.:  .:|.|..:    ..:..|..|| :.|:.::.||
  Rat    28 VTSKASASRAPKEVPLCPLMTDGETRNVTSLPGPTNWPLLGSLLEIFWKGGLKKQHDTLAEY--- 89

  Fly    75 MRKRYGDIYVMPGMFGRKDWVTTFNTKDIEMVFRNEGIWPRRDGLDSIVYFREHVRPDVYGEVQG 139
             .|:||.|:.|  ..|..|.|...:...:|.::|.|...|:|..:.....:|:| |.:.|    |
  Rat    90 -HKKYGQIFRM--KLGSFDSVHLGSPSLLEALYRTESAHPQRLEIKPWKAYRDH-RNEAY----G 146

  Fly   140 LVASQNEAWGKLRSAINPIFMQPRGLRMYYEPLSNINNEFIERIKEIRDPKTLEVPEDFTDEISR 204
            |:..:.:.|.::|||.....|:|..:....:.::.:..:|:||:.|:.|.:. .:| |...|:::
  Rat   147 LMILEGQEWQRVRSAFQKKLMKPVEIMKLDKKINEVLADFLERMDELCDERG-RIP-DLYSELNK 209

  Fly   205 LVFESLGLVAFDRQMGLIRKNRDNSDALTLFQTSRDIFRLTFKLDIQPSMWKIISTPTYRKMKRT 269
            ..|||:.||.::::.||::|..: .:||| |.|:......||        .|::.||.  ::.:.
  Rat   210 WSFESICLVLYEKRFGLLQKETE-EEALT-FITAIKTMMSTF--------GKMMVTPV--ELHKR 262

  Fly   270 LNDSLNVAQKM-----LKENQDALEKRRQAGEKINSNSMLERLMEID---PKVAVIMSLDILFAG 326
            ||..:..|..:     .|..:..::.|.|...:......|..:.:.|   .|.......::..|.
  Rat   263 LNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQDHLSKKELYAAVTELQLAA 327

  Fly   327 VDATATLLSAVLLCLSKHPDKQAKLREELLSIMPTKDSLLNEENMKDMPYLRAVIKETLRYYPNG 391
            |:.||..|..:|..||::|..|.:|.:|:.|::|...: ...|::::||||:|.:||::|..|:.
  Rat   328 VETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQT-PRAEDLRNMPYLKACLKESMRLTPSV 391

  Fly   392 LGTMRTCQNDVILSGYRVPKGTTVLLGSNVLMKEATYYPRPDEFLPERWLRDPETGKKMQVSPFT 456
            ..|.||.....:|..|.:||||.:.|.:.||......:....:|.|||||:     |:.:::||.
  Rat   392 PFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQ-----KEKKINPFA 451

  Fly   457 FLPFGFGPRMCIGKRVVDLEMETTVAKLIRNFHVEFNRDASRPFKTMFVMEPAITFPFKF 516
            .||||.|.|||||:|:.:|::...:..:|:.:.:....:.......:.::.|:...|..|
  Rat   452 HLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEMLHLGILVPSRELPIAF 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12d1-p	NP_001286304.1	p450	70..508	CDD:299894	120/445 (27%)
Cyp24a1	NP_963966.1	CYP24A1	90..508	CDD:410738	119/444 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	200	1.000	Inparanoid score	I3706
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	1	1.000	-	-		FOG0000720
OrthoInspector	1	1.000	-	-		mtm8942
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.870