Protein Alignment Cyp12d1-p and CYP27B1

DIOPT Version :9

• Sequence 1: NP_001286304.1
• Gene: Cyp12d1-p / 246648
• FlyBaseID: FBgn0050489
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_000776.1
• Gene: CYP27B1 / 1594
• HGNCID: 2606
• Length: 508
• Species: Homo sapiens
• Alignment Length: 504
• Identity: 128/504 - (25%)
• Similarity: 222/504 - (44%)
• Gaps: 64/504 - (12%)

  Fly    44 EIPRPNKFKFM-RAFMPGG-------EFQNASITEYTSAMRKRYGDIYVMPGMFGRKDWVTTFNT 100
            :||.|:...|: ..|..||       :.|.|:          .:|.:           |:.:|.|
Human    39 DIPGPSTPSFLAELFCKGGLSRLHELQVQGAA----------HFGPV-----------WLASFGT 82

  Fly   101 KD---------IEMVFRNEGIWPRRDGLDSIVYFREHVRPDVYGEVQGLVASQNEAWGKLRSAIN 156
            ..         :|.:.|.||..|.|   .|...:.||.|  ......||:.::.|.|.:|||.:.
Human    83 VRTVYVAAPALVEELLRQEGPRPER---CSFSPWTEHRR--CRQRACGLLTAEGEEWQRLRSLLA 142

  Fly   157 PIFMQPRGLRMYYEPLSNINNEFIERIKEIR----DPKTLEVPEDFTDEISRLVFESLGLVAFDR 217
            |:.::|:....|...|:|:..:.:.|::..|    .|..|  ..|...|..:...|.:..|....
Human   143 PLLLRPQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPAL--VRDVAGEFYKFGLEGIAAVLLGS 205

  Fly   218 QMGLIRKNRDNSDALTLFQTSRDIFRLTFKLDIQPSMWKIISTPTYRKMKRTLNDSLNVAQKML- 281
            ::|.: :.:...|..|..:....:|..|......|...:.:....:.::.|..:.....||:.:
Human   206 RLGCL-EAQVPPDTETFIRAVGSVFVSTLLTMAMPHWLRHLVPGPWGRLCRDWDQMFAFAQRHVE 269

  Fly   282 -KENQDALEKRRQAGEKINSNSMLERLM--EIDPKVAVIMSL-DILFAGVDATATLLSAVLLCLS 342
             :|.:.|:....|..:.:.|.:.|...:  |..|..:::.:: ::|.||||..:..||..|..||
Human   270 RREAEAAMRNGGQPEKDLESGAHLTHFLFREELPAQSILGNVTELLLAGVDTVSNTLSWALYELS 334

  Fly   343 KHPDKQAKLREEL-LSIMPTKDSLLNEENMKDMPYLRAVIKETLRYYPNGLGTMRTCQNDVILSG 406
            :||:.|..|..|: .::.|...:..:...:..:|.|:||:||.||.||...|..|....|:.:..
Human   335 RHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGD 399

  Fly   407 YRVPKGTTVLLGSNVLMKEATYYPRPDEFLPERWLRDPETGKKMQVSPFTFLPFGFGPRMCIGKR 471
            |.:||.|.|.|......::...:|.|:.|.|.|||     |:.....||..||||||.|.|:|:|
Human   400 YIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWL-----GEGPTPHPFASLPFGFGKRSCMGRR 459

  Fly   472 VVDLEMETTVAKLIRNFHVEFNRDAS--RPFKTMFVMEPAITFPFKFTD 518
            :.:||::..:|:::.:|.|:....|:  || ||..|:.|..:...:|.|
Human   460 LAELELQMALAQILTHFEVQPEPGAAPVRP-KTRTVLVPERSINLQFLD 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12d1-p	NP_001286304.1	p450	70..508	CDD:299894	116/458 (25%)
CYP27B1	NP_000776.1	p450	41..505	CDD:278495	125/498 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	194	1.000	Domainoid score	I3171
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	201	1.000	Inparanoid score	I3768
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48087
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8467
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.880