Protein Alignment Cyp12d1-p and CYP11B1

DIOPT Version :10

• Sequence 1: NP_610635.4
• Gene: Cyp12d1-p / 246648
• FlyBaseID: FBgn0050489
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_000488.3
• Gene: CYP11B1 / 1584
• HGNCID: 2591
• Length: 503
• Species: Homo sapiens
• Alignment Length: 429
• Identity: 111/429 - (25%)
• Similarity: 192/429 - (44%)
• Gaps: 44/429 - (10%)

  Fly   101 KDIEMVFRNEGIWPRRDGLDSIVYFREHVRPDVYGEVQGLVASQNEAWGKLRSAINPIFMQPRGL 165
            :|:|.:.:.:.:.|.|..|:..|.:|:|     .|...|:.......|...|..:||..:.|..:
Human    95 EDVEKLQQVDSLHPHRMSLEPWVAYRQH-----RGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAV 154

  Fly   166 RMYYEPLSNINNEFIERIKE-----IRDPKTLEVPEDFTDEISRLVFESLGLVAFDRQMGLIRKN 225
            :.:...:..:..:|.:.:|:     .|...||:|    ...|.....|:..|..|..::||: .:
Human   155 QRFLPMVDAVARDFSQALKKKVLQNARGSLTLDV----QPSIFHYTIEASNLALFGERLGLV-GH 214

  Fly   226 RDNSDALTLFQTSRDIFRLTFKLDIQP---SMWKIISTPTYRKMKRTLNDSL-----NVAQKMLK 282
            ..:|.:|........:|:.|.:|...|   |.|   ::|...|......|.:     |..||:.
Human   215 SPSSASLNFLHALEVMFKSTVQLMFMPRSLSRW---TSPKVWKEHFEAWDCIFQYGDNCIQKIY- 275

  Fly   283 ENQDALEKRRQAGEKINSNSMLERLMEIDPKVAVIMSLDILFAGVDATATLLSAVLLCLSKHPDK 347
              |:....|.|....|.:..:|.  .|:.|......|:::....||.|...|...|..|:::|:.
Human   276 --QELAFSRPQQYTSIVAELLLN--AELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNV 336

  Fly   348 QAKLREELLSIMPTKDSLLNEENMK---DMPYLRAVIKETLRYYPNGLGTMRTCQNDVILSGYRV 409
            |..||:|.|:...:    ::|...|   ::|.|||.:|||||.||.||...|...:|::|..|.:
Human   337 QQALRQESLAAAAS----ISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHI 397

  Fly   410 PKGTTVLLGSNVLMKEATYYPRPDEFLPERWLRDPETGKKMQVSPFTFLPFGFGPRMCIGKRVVD 474
            |.||.|.:....|.:....:|||:.:.|:|||....:|:.     |..:|||||.|.|:|:|:.:
Human   398 PAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRN-----FYHVPFGFGMRQCLGRRLAE 457

  Fly   475 LEMETTVAKLIRNFHVEFNRDASRPFKTMFVMEPAITFP 513
            .||...:..::::..||............|::.|:: ||
Human   458 AEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSM-FP 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12d1-p	NP_610635.4	CYP24A1-like	76..508	CDD:410677	108/422 (26%)
CYP11B1	NP_000488.3	CYP11B	72..499	CDD:410737	111/429 (26%)