Protein Alignment Cyp12d1-p and Cyp46a1

DIOPT Version :9

• Sequence 1: NP_001286304.1
• Gene: Cyp12d1-p / 246648
• FlyBaseID: FBgn0050489
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_034140.1
• Gene: Cyp46a1 / 13116
• MGIID: 1341877
• Length: 500
• Species: Mus musculus
• Alignment Length: 517
• Identity: 124/517 - (23%)
• Similarity: 229/517 - (44%)
• Gaps: 71/517 - (13%)

  Fly    22 SASVLAHEQAKSSITEEHKTYDEIPRPNKFKFMRAFMP---------GGEFQNASITEYTSAMRK 77
            ||.:||.....:.:......|:.||.|.:..|:...:|         |...|:..:.     ..|
Mouse    10 SAVLLAFGLCCTFVHRARSRYEHIPGPPRPSFLLGHLPYFWKKDEDCGRVLQDVFLD-----WAK 69

  Fly    78 RYGDIYVMPGMFGRKDWVTTFNTKDIEMVFRNEGIWPRRDGLDSIVYFREHVRPDVYGE---VQG 139
            :||.: |...:|.:...:.|    ..|.|  .:.:...:...||.:|   .....|:||   .||
Mouse    70 KYGPV-VRVNVFYKTSVIVT----SPESV--KKFLMSTKYNKDSKMY---RALQTVFGERLFGQG 124

  Fly   140 LVASQNEA-WGKLRSAINPIFMQPRGLRMYYEPLSNINNEFIERIKEIRDPKT-LEVPEDFTDEI 202
            ||:..:.. |.|.|..::..|.     |.....|....||..|::.||.:.|. .:.|....|.:
Mouse   125 LVSECDYGRWYKQRKVMDLAFS-----RSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDML 184

  Fly   203 SRLVFESLGLVAFDRQMG-LIRKNRDNSDALTLFQTSRDIFRLTFKLDIQPSMWKIISTPTYRKM 266
            :....:.|...||..:.. |:...:..|.|:.:........|.|        :.|.:  |..||.
Mouse   185 TCATIDILAKAAFGMETSMLLGAQKPLSQAVKVMLEGISASRNT--------LAKFM--PGKRKQ 239

  Fly   267 KRTLNDSLNVAQKMLKENQDALEKRRQA---GEKINSNSMLERLMEI-----DPKVAVIMSLDIL 323
            .|.:.:|:.:.:::   .:|.:::||:|   ||.:.:: :|.::::.     |.:|.:...:...
Mouse   240 LREIRESIRLLRQV---GKDWVQRRREALKRGEDMPAD-ILTQILKAEEGAQDDEVLLDNFVTFF 300

  Fly   324 FAGVDATATLLSAVLLCLSKHPDKQAKLREELLSIMPTKDSLLNEENMKDMPYLRAVIKETLRYY 388
            .||.:.:|..|:..::.||:.|:..|:|:.|:..::.:|.. |:.|::..:.||..|:||:||.|
Mouse   301 IAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVVGSKRH-LDYEDLGRLQYLSQVLKESLRLY 364

  Fly   389 PNGLGTMRTCQNDVILSGYRVPKGTTVLLGSNVLMKEATYYPRPDEFLPERWLRDPETGKKMQVS 453
            |...||.|..:.:.::.|.|||..|.:|..:.|:.:..||:..|..|.|:|:      |......
Mouse   365 PPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRF------GPGAPKP 423

  Fly   454 PFTFLPFGFGPRMCIGKRVVDLEMETTVAKLIRNFHVEFNRDASRPF-----KTMFVMEPAI 510
            .||:.||..|.|.|||::...:|::..:|||::  .:||.....:.|     .|:..::|.:
Mouse   424 RFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQ--RIEFRLVPGQRFGLQEQATLKPLDPVL 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12d1-p	NP_001286304.1	p450	70..508	CDD:299894	111/456 (24%)
Cyp46a1	NP_034140.1	p450	34..466	CDD:278495	115/474 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D825914at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010