DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp12d1-p and Cyp27b1

DIOPT Version :9

Sequence 1:	NP_001286304.1	Gene:	Cyp12d1-p / 246648	FlyBaseID:	FBgn0050489	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_446215.1	Gene:	Cyp27b1 / 114700	RGDID:	69192	Length:	501	Species:	Rattus norvegicus

Alignment Length:	505	Identity:	132/505 - (26%)
Similarity:	222/505 - (43%)	Gaps:	58/505 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 KTYDEIPRPNKFKFM-RAFMPGGEFQNASITEYTSAMRKRYGDIYVMPGMFGRKDWVTTFNTKDI 103
            ::..:||.|:...|: ..|..||..:...:..:.:|   |||.|:  .|.||....|...:...:
  Rat    28 RSLSDIPGPSTPSFLAELFCKGGLSRLHELQVHGAA---RYGPIW--SGSFGTLRTVYVADPALV 87

  Fly   104 EMVFRNEGIWPRRDGLDSIVYFREHVRPDVYGEVQGLVASQNEAWGKLRSAINPIFMQPRGLRMY 168
            |.:.|.|...|.|....|   :.||.|.  :....||:.:..|.|.:|||.:.|:.::|:....|
  Rat    88 EQLLRQESHCPERCSFSS---WSEHRRR--HQRACGLLTADGEEWQRLRSLLAPLLLRPQAAAGY 147

  Fly   169 YEPLSNINNEFIERIKEIRDPKTLEVPE---DFTDEISRLVFESLGLVAFDRQMGLIRKNRDNSD 230
            ...|.::.::.:.|::..|. :...:|:   |...|..:...|.:|.|....::|.:..... .|
  Rat   148 AGTLDSVVSDLVRRLRRQRG-RGSGLPDLVLDVAGEFYKFGLEGIGAVLLGSRLGCLEAEVP-PD 210

  Fly   231 ALTLFQTSRDIFRLTFKLDIQPSMW--KIISTPTYRKMKRTLNDSLNVAQKMLKENQDALEKRRQ 293
            ..|..:....:|..|......|| |  ::|..| :.::.|..:.....|||.:::.:.....|.|
  Rat   211 TETFIEAVGSVFVSTLLTMAMPS-WLHRLIPGP-WARLCRDWDQMFAFAQKHVEQREGEAAVRNQ 273

  Fly   294 A-----------------GEKINSNSMLERLMEIDPKVAVIMSLDILFAGVDATATLLSAVLLCL 341
            .                 .||::..|::..:.|            :|.||||..:..||..|..|
  Rat   274 GKPEEDLPTGHHLTHFLFREKVSVQSIVGNVTE------------LLLAGVDTVSNTLSWALYEL 326

  Fly   342 SKHPDKQAKLREELL-SIMPTKDSLLNEENMKDMPYLRAVIKETLRYYPNGLGTMRTCQNDVILS 405
            |:||:.|:.|..|:. ::.|...:.|....:..:|.|:|||||.||.||...|..|....|:.:.
  Rat   327 SRHPEVQSALHSEITGAVNPGSYAHLQATALSQLPLLKAVIKEVLRLYPVVPGNSRVPDRDICVG 391

  Fly   406 GYRVPKGTTVLLGSNVLMKEATYYPRPDEFLPERWLRDPETGKKMQVSPFTFLPFGFGPRMCIGK 470
            .|.:|:.|.|.|......::...:..|:.|.|.|||     |:.....||..||||||.|.|||:
  Rat   392 NYVIPQDTLVSLCHYATSRDPAQFREPNSFNPARWL-----GEGPAPHPFASLPFGFGKRSCIGR 451

  Fly   471 RVVDLEMETTVAKLIRNFHVEFNRDASRPFK--TMFVMEPAITFPFKFTD 518
            |:.:||::..:|:::.:|.| .....:.|.|  |..|:.|..:...:|.|
  Rat   452 RLAELELQMALAQILTHFEV-LPEPGALPVKPMTRTVLVPERSIHLQFVD 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12d1-p	NP_001286304.1	p450	70..508	CDD:299894	122/462 (26%)
Cyp27b1	NP_446215.1	CYP27B1	61..496	CDD:410741	123/466 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	196	1.000	Domainoid score	I3026
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	200	1.000	Inparanoid score	I3706
OMA	1	1.010	-	-		QHG48087
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8942
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.880