Protein Alignment Cyp12d1-p and Cyp27b1

DIOPT Version :10

• Sequence 1: NP_610635.4
• Gene: Cyp12d1-p / 246648
• FlyBaseID: FBgn0050489
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_446215.1
• Gene: Cyp27b1 / 114700
• RGDID: 69192
• Length: 501
• Species: Rattus norvegicus
• Alignment Length: 505
• Identity: 132/505 - (26%)
• Similarity: 222/505 - (43%)
• Gaps: 58/505 - (11%)

  Fly    40 KTYDEIPRPNKFKFM-RAFMPGGEFQNASITEYTSAMRKRYGDIYVMPGMFGRKDWVTTFNTKDI 103
            ::..:||.|:...|: ..|..||..:...:..:.:|   |||.|:  .|.||....|...:...:
  Rat    28 RSLSDIPGPSTPSFLAELFCKGGLSRLHELQVHGAA---RYGPIW--SGSFGTLRTVYVADPALV 87

  Fly   104 EMVFRNEGIWPRRDGLDSIVYFREHVRPDVYGEVQGLVASQNEAWGKLRSAINPIFMQPRGLRMY 168
            |.:.|.|...|.|....|   :.||.|.  :....||:.:..|.|.:|||.:.|:.::|:....|
  Rat    88 EQLLRQESHCPERCSFSS---WSEHRRR--HQRACGLLTADGEEWQRLRSLLAPLLLRPQAAAGY 147

  Fly   169 YEPLSNINNEFIERIKEIRDPKTLEVPE---DFTDEISRLVFESLGLVAFDRQMGLIRKNRDNSD 230
            ...|.::.::.:.|::..|. :...:|:   |...|..:...|.:|.|....::|.:..... .|
  Rat   148 AGTLDSVVSDLVRRLRRQRG-RGSGLPDLVLDVAGEFYKFGLEGIGAVLLGSRLGCLEAEVP-PD 210

  Fly   231 ALTLFQTSRDIFRLTFKLDIQPSMW--KIISTPTYRKMKRTLNDSLNVAQKMLKENQDALEKRRQ 293
            ..|..:....:|..|......|| |  ::|..| :.::.|..:.....|||.:::.:.....|.|
  Rat   211 TETFIEAVGSVFVSTLLTMAMPS-WLHRLIPGP-WARLCRDWDQMFAFAQKHVEQREGEAAVRNQ 273

  Fly   294 A-----------------GEKINSNSMLERLMEIDPKVAVIMSLDILFAGVDATATLLSAVLLCL 341
            .                 .||::..|::..:.|            :|.||||..:..||..|..|
  Rat   274 GKPEEDLPTGHHLTHFLFREKVSVQSIVGNVTE------------LLLAGVDTVSNTLSWALYEL 326

  Fly   342 SKHPDKQAKLREELL-SIMPTKDSLLNEENMKDMPYLRAVIKETLRYYPNGLGTMRTCQNDVILS 405
            |:||:.|:.|..|:. ::.|...:.|....:..:|.|:|||||.||.||...|..|....|:.:.
  Rat   327 SRHPEVQSALHSEITGAVNPGSYAHLQATALSQLPLLKAVIKEVLRLYPVVPGNSRVPDRDICVG 391

  Fly   406 GYRVPKGTTVLLGSNVLMKEATYYPRPDEFLPERWLRDPETGKKMQVSPFTFLPFGFGPRMCIGK 470
            .|.:|:.|.|.|......::...:..|:.|.|.|||     |:.....||..||||||.|.|||:
  Rat   392 NYVIPQDTLVSLCHYATSRDPAQFREPNSFNPARWL-----GEGPAPHPFASLPFGFGKRSCIGR 451

  Fly   471 RVVDLEMETTVAKLIRNFHVEFNRDASRPFK--TMFVMEPAITFPFKFTD 518
            |:.:||::..:|:::.:|.| .....:.|.|  |..|:.|..:...:|.|
  Rat   452 RLAELELQMALAQILTHFEV-LPEPGALPVKPMTRTVLVPERSIHLQFVD 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12d1-p	NP_610635.4	CYP24A1-like	76..508	CDD:410677	121/456 (27%)
Cyp27b1	NP_446215.1	CYP27B1	61..496	CDD:410741	123/466 (26%)