DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30486 and CRISP2

DIOPT Version :9

Sequence 1:	NP_725234.2	Gene:	CG30486 / 246645	FlyBaseID:	FBgn0050486	Length:	263	Species:	Drosophila melanogaster
Sequence 2:	XP_005249406.1	Gene:	CRISP2 / 7180	HGNCID:	12024	Length:	278	Species:	Homo sapiens

Alignment Length:	215	Identity:	46/215 - (21%)
Similarity:	76/215 - (35%)	Gaps:	53/215 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LLSVLIIVLISQEALSTDYCNKDLCLPEITHIACRNYGDFDESCGSEAIIMKFPMHMRAHLLAVL 68
            ||.||.:|.:...:|..:  .||   |..|                  .::...:.::..::...
Human     3 LLPVLFLVTVLLPSLPAE--GKD---PAFT------------------ALLTTQLQVQREIVNKH 44

  Fly    69 NDFRNTVAKGQYPHLRPASRMATLRWHEELAGLAKFALRRC--DYIDDYCSNTDEFSYVSYIYGS 131
            |:.|..|:.       |||.|..:.|..|:...|:....:|  .:.|.....|           |
Human    45 NELRKAVSP-------PASNMLKMEWSREVTTNAQRWANKCTLQHSDPEDRKT-----------S 91

  Fly   132 TKW---LQLEKDPISVLDFVLQFWMDDVKGCTMAHINAEKPAKDGQCRGYFTQLVQDLAAHVGCA 193
            |:.   |.:..||.| ....:|.|.|::    :..:....|.......|::||||......|||.
Human    92 TRCGENLYMSSDPTS-WSSAIQSWYDEI----LDFVYGVGPKSPNAVVGHYTQLVWYSTYQVGCG 151

  Fly   194 MMLRKGQTSGLYQYGVLCHF 213
            :.....|.|..|.|  :|.:
Human   152 IAYCPNQDSLKYYY--VCQY 169

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30486	NP_725234.2	SCP_euk	61..214	CDD:240180	36/158 (23%)
CRISP2	XP_005249406.1	SCP_CRISP	35..172	CDD:240183	36/160 (23%)
CRISP2	XP_005249406.1	Crisp	224..278	CDD:285731
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151291
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2340
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	49	1.000	Inparanoid score	I5480
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1528782at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.800