DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pgant9 and Galnt5

DIOPT Version :9

Sequence 1:	NP_001097342.1	Gene:	Pgant9 / 246627	FlyBaseID:	FBgn0050463	Length:	650	Species:	Drosophila melanogaster
Sequence 2:	NP_113984.1	Gene:	Galnt5 / 83627	RGDID:	620361	Length:	930	Species:	Rattus norvegicus

Alignment Length:	702	Identity:	248/702 - (35%)
Similarity:	353/702 - (50%)	Gaps:	131/702 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LVYTDDT---RRRAAQEGAGASGAGSAPGVGGGAGGLGDPIALALRNEPAGEDFGINGNVIGGGG 90
            |.:|.|.   ::::..|    :|.|..|...|.....|..:           :|..:..||....
  Rat   272 LKFTADVGHLKKQSTNE----TGLGVLPEADGAKVAPGKKL-----------NFSESQIVIITKE 321

  Fly    91 QKQAHDEADIP----PTV---------GKHKADLQAERMR-----KKAAEQPKKKPQED------ 131
            :.|..|..::|    .||         |||....|::.:.     |:|..|.|....|:
  Rat   322 EGQKTDTKEVPNSKIQTVFPKLLGESQGKHIPRSQSQTLSSPLAPKRAVSQSKPTLAEELHTARS 386

  Fly   132 ---SKKVI----DPPANFEEN--------------------PGELGKPVRLPKEMSDEMKKAVDD 169
               :|...    ...||..||                    ||:.|:||.:|    ...||..:.
  Rat   387 NLTAKATTVGHQQSHANISENPGKHHVLRIDVTLSPRDLNAPGQFGRPVVVP----PGKKKEAEQ 447

  Fly   170 GWTKNAFNQYVSDLISVHRTLPDPRDAWCKDEARYLTNLPKTDVIICFHNEAWTVLLRTVHSVLD 234
            .|.:..||.|:||||.|.|.:.|.|.|.|.::..: .:||.|.:|:||.:|.|:.|||:|||||:
  Rat   448 RWKEGNFNVYLSDLIPVDRAIEDTRPAGCAEQLVH-NDLPTTSIIMCFVDEVWSALLRSVHSVLN 511

  Fly   235 RSPEHLIGKIILVDDYSDMPHLKRQLEDYFAAYPKVQIIRGQKREGLIRARILGANHAKSPVLTY 299
            |||.|||.:|:||||:|...:||..|:.|.:.:|||:|:|.::|.||||||:.||.:|...|||:
  Rat   512 RSPPHLIKEILLVDDFSTKDYLKANLDKYMSQFPKVRILRLKERHGLIRARLAGAQNATGDVLTF 576

  Fly   300 LDSHCECTEGWLEPLLDRIARNSTTVVCPVIDVISDETLEYHYRDSGGVNVGGFDWNLQFSWHPV 364
            ||||.||..|||||||:|:..|...|.||||:||:|:.:.|...|:  ...|.|.|.:.|.|..:
  Rat   577 LDSHVECNVGWLEPLLERVYLNRKKVACPVIEVINDKDMSYMTVDN--FQRGVFTWPMNFGWRTI 639

  Fly   365 -PERERKRHNSTAEPVYSPTMAGGLFSIDREFFDRLGTYDSGFDIWGGENLELSFKTWMCGGTLE 428
             |:...|......:.:..|.|||||||||:.:|..|||||.|.|:|||||:|||||.|||||.:|
  Rat   640 PPDVIAKNGIKETDIIRCPVMAGGLFSIDKSYFYELGTYDPGLDVWGGENMELSFKVWMCGGEIE 704

  Fly   429 IVPCSHVGHIFRKRSPYKW-RSGVNVLKKNSVRLAEVWMDEYSQYYY----HRIGNDKG-DWGDV 487
            |:|||.||||||..:||.: :..:..:::|.||:||||:|||.:.:|    |.|  |:| |.|::
  Rat   705 IIPCSRVGHIFRNDNPYSFPKDRMKTVERNLVRVAEVWLDEYKELFYGHGDHLI--DQGLDVGNL 767

  Fly   488 SDRRKLRNDLKCKSFKWYLDNIYPELFIPGDSVAHGEIRNLGYGGRTCLDAPAGKKHQKKAVGTY 552
            :.:|:||..|||:||||||||::|:|..|... |.|...||..|  .|:..      :...|...
  Rat   768 TQQRELRKKLKCQSFKWYLDNVFPDLKAPVVR-ASGVFINLALG--KCVSI------KNITVVLE 823

  Fly   553 PC----HRQGGNQYWM-LSKAGEIRRDDSCL----DYAGKDVTLFGCHGGKGNQFWTYR------ 602
            .|    ..|..|..|: |.|.||     .|:    |..  .:||:.|........|.:|
  Rat   824 DCDGSSELQQFNYTWVRLIKHGE-----WCVAPIPDKG--SLTLYPCDNRNNRLKWLHRSASAFH 881

  Fly   603 ---------ENTKQLHHGTSGKCLAISESKDKLLMEECSASLSRQQWTLENY 645
                     |:.:||      .|:..:.|:..|.:..|:.:..:|:|..|.|
  Rat   882 PELVDHIVFESYQQL------LCMEGNFSQKTLKLAACNPTEPQQKWKFEKY 927

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant9	NP_001097342.1	WcaA	207..>478	CDD:223539	140/276 (51%)
		pp-GalNAc-T	213..510	CDD:133004	156/303 (51%)
		Ricin_B_lectin	521..640	CDD:279046	30/142 (21%)
		RICIN	523..642	CDD:238092	30/142 (21%)
Galnt5	NP_113984.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	163..210
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	344..377		8/32 (25%)
		WcaA	484..>599	CDD:223539	64/114 (56%)
		Catalytic subdomain A	485..594		63/108 (58%)
		pp-GalNAc-T	489..790	CDD:133004	156/304 (51%)
		Catalytic subdomain B	654..716		42/61 (69%)
		RICIN	804..925	CDD:214672	29/141 (21%)
		RICIN	810..924	CDD:238092	27/134 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345970
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D606683at2759
OrthoFinder	1	1.000	-	-		FOG0002384
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11675
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.810