DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant9 and GALNT7

DIOPT Version :9

Sequence 1:	NP_001097342.1	Gene:	Pgant9 / 246627	FlyBaseID:	FBgn0050463	Length:	650	Species:	Drosophila melanogaster
Sequence 2:	NP_001362528.1	Gene:	GALNT7 / 51809	HGNCID:	4129	Length:	657	Species:	Homo sapiens

Alignment Length:	649	Identity:	237/649 - (36%)
Similarity:	336/649 - (51%)	Gaps:	91/649 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 DPIALALRNEPAGEDFGINGNVIGGGGQKQAHDEADIPPTV-GKH----KADLQAERMRKKAAEQ 123
            ||..|:...    ||..:|..:...||...|..|....|.| ..|    :.||::.|...||..:
Human    34 DPSPLSRMR----EDRDVNDPMPNRGGNGLAPGEDRFKPVVPWPHVEGVEVDLESIRRINKAKNE 94

  Fly   124 PKKKPQEDSKKVI----------------DPP------ANFE----ENPGELGKP--VRLPKEMS 160
            .:.....||:|.|                ||.      .|||    |.||.:|.|  ...|..:.
Human    95 QEHHAGGDSQKDIMQRQYLTFKPQTFTYHDPVLRPGILGNFEPKEPEPPGVVGGPGEKAKPLVLG 159

  Fly   161 DEMKKAVDDGWTKNAFNQYVSDLISVHRTLPDPRDAWCK----DEARYLTNLPKTDVIICFHNEA 221
            .|.|:|:.....:..||...||:||:.|::.|.|...||    ||     ||..:.|:|.||||.
Human   160 PEFKQAIQASIKEFGFNMVASDMISLDRSVNDLRQEECKYWHYDE-----NLLTSSVVIVFHNEG 219

  Fly   222 WTVLLRTVHSVLDRSPEHLIGKIILVDDYSDMPHLKRQLEDYFAAY-PKVQIIRGQKREGLIRAR 285
            |:.|:||||||:.|:|...:.:|:|:||:|:..|||.:|::|...: ..|::.|.::|||||:||
Human   220 WSTLMRTVHSVIKRTPRKYLAEIVLIDDFSNKEHLKEKLDEYIKLWNGLVKVFRNERREGLIQAR 284

  Fly   286 ILGANHAK-SPVLTYLDSHCECTEGWLEPLLDRIARNSTTVVCPVIDVI--SDETLE-YHYRDSG 346
            .:||..|| ..||.|||:|||....|..||:..|:::.||...|:||.|  :|.::| ....|..
Human   285 SIGAQKAKLGQVLIYLDAHCEVAVNWYAPLVAPISKDRTTCTVPLIDYIDGNDYSIEPQQGGDED 349

  Fly   347 GVNVGGFDWNLQFSWHPVPERERKRHNSTAEPVYSPTMAGGLFSIDREFFDRLGTYDSGFDIWGG 411
            |...|.:||:|.:...|:..:|:.:.....||..||.||||||:|:||||..||.||.|..||||
Human   350 GFARGAWDWSLLWKRIPLSHKEKAKRKHKTEPYRSPAMAGGLFAIEREFFFELGLYDPGLQIWGG 414

  Fly   412 ENLELSFKTWMCGGTLEIVPCSHVGHIFRKRSPYKWRS-------GVNVLKKNSVRLAEVWMDEY 469
            ||.|:|:|.|.|||.|..||||.||||:|...   |:.       |.:...||.||:.|||.|||
Human   415 ENFEISYKIWQCGGKLLFVPCSRVGHIYRLEG---WQGNPPPIYVGSSPTLKNYVRVVEVWWDEY 476

  Fly   470 SQYYY-HRIGNDKGDWGDVSDRRKLRNDLKCKSFKWYLDNI-------YPELFIPGDSVAHGEIR 526
            ..|:| .|..:....:||:|:.:|.|.|..||||||:::.|       ||   :|..:|..||||
Human   477 KDYFYASRPESQALPYGDISELKKFREDHNCKSFKWFMEEIAYDITSHYP---LPPKNVDWGEIR 538

  Fly   527 NLGYGGRTCLDAPAGKKHQKKAVGTY----PCHRQGGNQYWMLSKAGEIRRDDSCLDYA--GKDV 585
              |:....|:|: .||.:     |.:    ||||.||||.:.:::|.::.:.|.||...  |..|
Human   539 --GFETAYCIDS-MGKTN-----GGFVELGPCHRMGGNQLFRINEANQLMQYDQCLTKGADGSKV 595

  Fly   586 TLFGCHGGKGNQF--WTYRENTKQLHHGTSGKCLAISESKDKLLMEECSASLSRQQWTLENYDS 647
            .:..|:   .|:|  |.|.:|..:..|..|||||..||...::.:..|.:|.:.|:|.:.|..|
Human   596 MITHCN---LNEFKEWQYFKNLHRFTHIPSGKCLDRSEVLHQVFISNCDSSKTTQKWEMNNIHS 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant9	NP_001097342.1	WcaA	207..>478	CDD:223539	127/283 (45%)
		pp-GalNAc-T	213..510	CDD:133004	138/316 (44%)
		Ricin_B_lectin	521..640	CDD:279046	41/126 (33%)
		RICIN	523..642	CDD:238092	42/126 (33%)
GALNT7	NP_001362528.1	pp-GalNAc-T	210..518	CDD:133004	137/310 (44%)
GALNT7	NP_001362528.1	Ricin_B_lectin	534..649	CDD:366226	41/125 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152450
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D606683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750