DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pgant9 and Galnt7

DIOPT Version :9

Sequence 1:	NP_001097342.1	Gene:	Pgant9 / 246627	FlyBaseID:	FBgn0050463	Length:	650	Species:	Drosophila melanogaster
Sequence 2:	NP_075215.1	Gene:	Galnt7 / 29750	RGDID:	620362	Length:	657	Species:	Rattus norvegicus

Alignment Length:	655	Identity:	235/655 - (35%)
Similarity:	331/655 - (50%)	Gaps:	103/655 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 DPIALALRNEPAGEDFGINGNVIGGGGQKQAHDEADIPPTV-GKH----KADLQAERMRKKAAEQ 123
            ||..|:...    ||..:|..:...||...|..:....|.| ..|    :.||::.|.:.||..:
  Rat    34 DPSPLSRMR----EDRDVNNPLPNRGGNGLAPGDDRFKPVVPWPHVEGVEVDLESIRRKNKAKNE 94

  Fly   124 PKKKPQEDSKKVI----------------DPP------ANFEE----------NPGELGKPVRLP 156
            .::....||:|.|                ||.      .|||.          .|||..||:.|
  Rat    95 QERHAGGDSQKDIMQRQYLTFKPQTFTYRDPVLRPGVLGNFEPKEPEPHGVVGGPGENAKPLVL- 158

  Fly   157 KEMSDEMKKAVDDGWTKNAFNQYVSDLISVHRTLPDPRDAWCK----DEARYLTNLPKTDVIICF 217
               ..|.|:|......:..||...||:||:.|::.|.|...||    ||     ||..:.|:|.|
  Rat   159 ---GPEYKQAAQASIKEFGFNMAASDMISLDRSVNDLRQEECKYWHYDE-----NLLTSSVVIVF 215

  Fly   218 HNEAWTVLLRTVHSVLDRSPEHLIGKIILVDDYSDMPHLKRQLEDYFAAY-PKVQIIRGQKREGL 281
            |||.|:.|:||||||:.|:|...:.:|:|:||:|:..|||.:|.:|...: ..|::.|.::||||
  Rat   216 HNEGWSTLMRTVHSVIKRTPRKYLAEIVLIDDFSNKEHLKEKLTEYIKLWNGLVKVFRNERREGL 280

  Fly   282 IRARILGANHAK-SPVLTYLDSHCECTEGWLEPLLDRIARNSTTVVCPVIDVISDETLEYHYR-- 343
            |:||.:||..|| ..||.|||:|||....|..||:..|:::.|....|:||||:..|.|...:
  Rat   281 IQARSIGAQKAKLGQVLIYLDAHCEVAVNWYAPLVAPISKDRTICTVPIIDVINGNTYEIIPQGG 345

  Fly   344 -DSGGVNVGGFDWNLQFSWHPVPERERKRHNSTAEPVYSPTMAGGLFSIDREFFDRLGTYDSGFD 407
             |..|...|.:||::.:...|:..||::...:..||..||.||||||:|:|:||..||.||.|..
  Rat   346 GDEDGYARGAWDWSMLWKRVPLTPREKRLRKTKTEPYRSPAMAGGLFAIERDFFFELGLYDPGLQ 410

  Fly   408 IWGGENLELSFKTWMCGGTLEIVPCSHVGHIFRKRSPYKWRS-------GVNVLKKNSVRLAEVW 465
            ||||||.|:|:|.|.|||.|..||||.||||:|...   |:.       |.:...||.||:.|||
  Rat   411 IWGGENFEISYKIWQCGGKLLFVPCSRVGHIYRLEG---WQGNPPPLYVGSSPTLKNYVRVVEVW 472

  Fly   466 MDEYSQYYYHRIGNDKG-DWGDVSDRRKLRNDLKCKSFKWYLDNI-------YPELFIPGDSVAH 522
            .|||..|:|......|. .:||:|:.:|.|.|..||||||:::.|       ||   :|..:|..
  Rat   473 WDEYKDYFYASRPESKALPYGDISELKKFREDHNCKSFKWFMEEIAYDITAHYP---LPPRNVEW 534

  Fly   523 GEIRNL--GYGGRTCLDAPAGKKHQKKAVGTY----PCHRQGGNQYWMLSKAGEIRRDDSCLDYA 581
            ||||.|  .|    |:|: .||.:     |.:    ||||.||||.:.:::|.::.:.|.||...
  Rat   535 GEIRGLETAY----CIDS-MGKTN-----GGFVELGPCHRMGGNQLFRINEANQLMQYDQCLTKG 589

  Fly   582 --GKDVTLFGCHGGKGNQF--WTYRENTKQLHHGTSGKCLAISESKDKLLMEECSASLSRQQWTL 642
              |..|.:..|:   .|:|  |.|.:|..:..|..|||||..||...::.:..|......|:|.:
  Rat   590 PDGSKVMITHCN---LNEFKEWQYFKNLHRFTHIASGKCLDRSEVLHQVFISSCDNGKMTQKWEM 651

  Fly   643 ENYDS 647
            .|..|
  Rat   652 NNIHS 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant9	NP_001097342.1	WcaA	207..>478	CDD:223539	125/282 (44%)
		pp-GalNAc-T	213..510	CDD:133004	137/316 (43%)
		Ricin_B_lectin	521..640	CDD:279046	41/128 (32%)
		RICIN	523..642	CDD:238092	42/128 (33%)
Galnt7	NP_075215.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..66		9/35 (26%)
		Catalytic subdomain A	206..317		51/110 (46%)
		pp-GalNAc-T	210..518	CDD:133004	136/310 (44%)
		WcaA	210..>331	CDD:223539	53/120 (44%)
		Catalytic subdomain B	381..443		40/61 (66%)
		Ricin_B_lectin	534..649	CDD:279046	41/127 (32%)
		RICIN	535..651	CDD:238092	42/128 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345966
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D606683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.750