DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pgant9 and GALNT8

DIOPT Version :9

Sequence 1:	NP_001097342.1	Gene:	Pgant9 / 246627	FlyBaseID:	FBgn0050463	Length:	650	Species:	Drosophila melanogaster
Sequence 2:	NP_059113.1	Gene:	GALNT8 / 26290	HGNCID:	4130	Length:	637	Species:	Homo sapiens

Alignment Length:	615	Identity:	199/615 - (32%)
Similarity:	303/615 - (49%)	Gaps:	84/615 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 LGDPIALALRNEPAGEDFGINGNVIGGGGQKQAHDEADIPPTVGKHKADLQAERMRKKAAEQPKK 126
            |.:.:.||||.:.     .:|..:      |:|.||  :.|.:         :.|..|..|..|.
Human    70 LKESMKLALRQQE-----NVNSTL------KRAKDE--VRPLL---------KAMETKVNETKKH 112

  Fly   127 KPQEDSKKVIDPPANFEENPGELGKPVRLPKEMSDEMKKAVDDGWTKNAFNQYVSDLISVHRTLP 191
            |.|    ..:.|.:......||         ::|:..:||..|.:.|..:|.|:|:.:.::||:|
Human   113 KTQ----MKLFPHSQLFRQWGE---------DLSEAQQKAAQDLFRKFGYNAYLSNQLPLNRTIP 164

  Fly   192 DPRDAWCKDEARYLTNLPKTDVIICFHNEAWTVLLRTVHSVLDRSPEHLIGKIILVDDYSDMPHL 256
            |.||..|..:. |.:.||...||:.|.|||.:::.|.:.|:::|:|..|:.:||||||:|....|
Human   165 DTRDYRCLRKT-YPSQLPSLSVILIFVNEALSIIQRAITSIINRTPSRLLKEIILVDDFSSNGEL 228

  Fly   257 KRQLED----YFAAYP-KVQIIRGQKREGLIRARILGANHAKSPVLTYLDSHCECTEGWLEPLLD 316
            |..|::    |...|| .::|||..:|:||.:||..|...|.:.|:..||:|.|...||.||:|.
Human   229 KVHLDEKIKLYNQKYPGLLKIIRHPERKGLAQARNTGWEAATADVVAILDAHIEVNVGWAEPILA 293

  Fly   317 RIARNSTTVVCPVIDVISDETLEYHYRDSGGVNVGGFDWNLQFSWHPVPERERKRHNSTAEPVYS 381
            ||..:.|.:|.||.|.|..:|.:.   |...:.|.||:|.|...:..:|:.....|:.|| ||.|
Human   294 RIQEDRTVIVSPVFDNIRFDTFKL---DKYELAVDGFNWELWCRYDALPQAWIDLHDVTA-PVKS 354

  Fly   382 PTMAGGLFSIDREFFDRLGTYDSGFDIWGGENLELSFKTWMCGGTLEIVPCSHVGHIFRKRSPYK 446
            |::. |:.:.:|.|...:|:.|.|..|:||||:|||.:.|.|||.:||:|||.:.|:.|...||.
Human   355 PSIM-GILAANRHFLGEIGSLDGGMLIYGGENVELSLRVWQCGGKVEILPCSRIAHLERHHKPYA 418

  Fly   447 WRSGVNVLKKNSVRLAEVWMDEYSQYYYHR----IGNDKGDWGDVSDRRKLRNDLKCKSFKWYLD 507
             ......||:|::|:||:||||:....|..    :.|...|:||||.|..||..||||:|.|||.
Human   419 -LDLTAALKRNALRVAEIWMDEHKHMVYLAWNIPLQNSGIDFGDVSSRMALREKLKCKTFDWYLK 482

  Fly   508 NIYPELFIPGDSVAHGEIRNLGYGGRTCLDAPAGKKHQKKAVGTYP----CHR-QGGNQYWMLSK 567
            |:||.|......|.:|.::|| .....|||       |....|..|    ||. ...|.|:.|:
Human   483 NVYPLLKPLHTIVGYGRMKNL-LDENVCLD-------QGPVPGNTPIMYYCHEFSSQNVYYHLT- 538

  Fly   568 AGEI---------RRDDSCLDYAGK--DVTLFGCHGGKGNQ---FWTYRENTKQLHHGTSGKCLA 618
             ||:         ...|.||...||  ..||..|.....|:   :|.::.....::..|. :||.
Human   539 -GELYVGQLIAEASASDRCLTDPGKAEKPTLEPCSKAAKNRLHIYWDFKPGGAVINRDTK-RCLE 601

  Fly   619 ISE---SKDKLLMEECSASLSRQQWTLENY 645
            :.:   ....|:::.||..:...|.|:.::
Human   602 MKKDLLGSHVLVLQTCSTQVWEIQHTVRDW 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant9	NP_001097342.1	WcaA	207..>478	CDD:223539	107/279 (38%)
		pp-GalNAc-T	213..510	CDD:133004	123/305 (40%)
		Ricin_B_lectin	521..640	CDD:279046	32/140 (23%)
		RICIN	523..642	CDD:238092	33/140 (24%)
GALNT8	NP_059113.1	transmembrane domain	7..29
		stem region	30..148		25/112 (22%)
		SMC_N	<48..>161	CDD:330553	28/125 (22%)
		GT1 motif	182..298		46/115 (40%)
		pp-GalNAc-T	184..485	CDD:133004	123/306 (40%)
		Gal/GalNAc transferase motif	358..397		16/39 (41%)
		RICIN	498..624	CDD:238092	32/136 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152460
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740