DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pgant9 and GALNT3

DIOPT Version :9

Sequence 1:	NP_001097342.1	Gene:	Pgant9 / 246627	FlyBaseID:	FBgn0050463	Length:	650	Species:	Drosophila melanogaster
Sequence 2:	NP_004473.2	Gene:	GALNT3 / 2591	HGNCID:	4125	Length:	633	Species:	Homo sapiens

Alignment Length:	535	Identity:	231/535 - (43%)
Similarity:	319/535 - (59%)	Gaps:	30/535 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 KKVIDPPANFEENPGELGKPVRLPKEMSDEMKKAVDDGWTKNAFNQYVSDLISVHRTL-PDPRDA 196
            |.|:|.|......||..||..: ...:|.|.:|..:.|..|:.||.:.||.||:||.| ||.|..
Human   108 KPVLDRPPQDSNAPGASGKAFK-TTNLSVEEQKEKERGEAKHCFNAFASDRISLHRDLGPDTRPP 171

  Fly   197 WC-KDEARYLTNLPKTDVIICFHNEAWTVLLRTVHSVLDRSPEHLIGKIILVDDYSDMPHLKRQL 260
            .| :.:.:....||.|.|||.||||||:.|||||||||..||..|:.:||||||.|...:|..:|
Human   172 ECIEQKFKRCPPLPTTSVIIVFHNEAWSTLLRTVHSVLYSSPAILLKEIILVDDASVDEYLHDKL 236

  Fly   261 EDYFAAYPKVQIIRGQKREGLIRARILGANHAKSPVLTYLDSHCECTEGWLEPLLDRIARNSTTV 325
            ::|...:..|:|:|.::|:|||.||:|||..|.:..||:||:||||..|||||||.|||.|.|.|
Human   237 DEYVKQFSIVKIVRQRERKGLITARLLGATVATAETLTFLDAHCECFYGWLEPLLARIAENYTAV 301

  Fly   326 VCPVIDVISDETLEYHYRDSGGV--NVGGFDWNLQFSWHPVPERERKRHNSTAEPVYSPTMAGGL 388
            |.|.|..|...|.|::.....|.  |.|.|||:|.|.|..:|:.|::|......|:.:||.||||
Human   302 VSPDIASIDLNTFEFNKPSPYGSNHNRGNFDWSLSFGWESLPDHEKQRRKDETYPIKTPTFAGGL 366

  Fly   389 FSIDREFFDRLGTYDSGFDIWGGENLELSFKTWMCGGTLEIVPCSHVGHIFRKRSPYKWRSGVNV 453
            |||.:|:|:.:|:||...:||||||:|:||:.|.|||.|||:|||.|||:||.:||:.:..|..|
Human   367 FSISKEYFEYIGSYDEEMEIWGGENIEMSFRVWQCGGQLEIMPCSVVGHVFRSKSPHSFPKGTQV 431

  Fly   454 LKKNSVRLAEVWMDEYSQYYYHR------IGNDKGDWGDVSDRRKLRNDLKCKSFKWYLDNIYPE 512
            :.:|.|||||||||||.:.:|.|      |...|. :||:|.|.::::.|:||:|.|||:|||||
Human   432 IARNQVRLAEVWMDEYKEIFYRRNTDAAKIVKQKA-FGDLSKRFEIKHRLQCKNFTWYLNNIYPE 495

  Fly   513 LFIPG-DSVAHGEIRNLGYGGRTCLDAPAGKKHQ-KKAVGTYPCHRQGGNQYWMLSKAGEIRRD- 574
            :::|. :.|..|.|:::|.  ..|||  .|:.:| .|.:..|.||..|||||:..|...|||.:
Human   496 VYVPDLNPVISGYIKSVGQ--PLCLD--VGENNQGGKPLIMYTCHGLGGNQYFEYSAQHEIRHNI 556

  Fly   575 --DSCLDYAGKDVTLFGC--HGGK----GNQFWTYRENTKQLHHGTSGKCLAISESKDKLLMEEC 631
              :.||..|...|.|..|  .|.|    |.|.|..::: :.|::.....||:.:.....|:  .|
Human   557 QKELCLHAAQGLVQLKACTYKGHKTVVTGEQIWEIQKD-QLLYNPFLKMCLSANGEHPSLV--SC 618

  Fly   632 SASLSRQQWTLENYD 646
            :.|...|:|.|...|
Human   619 NPSDPLQKWILSQND 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant9	NP_001097342.1	WcaA	207..>478	CDD:223539	143/278 (51%)
		pp-GalNAc-T	213..510	CDD:133004	154/304 (51%)
		Ricin_B_lectin	521..640	CDD:279046	39/128 (30%)
		RICIN	523..642	CDD:238092	40/128 (31%)
GALNT3	NP_004473.2	Catalytic subdomain A	184..293		62/108 (57%)
		pp-GalNAc-T	188..493	CDD:133004	154/305 (50%)
		Catalytic subdomain B	356..418		37/61 (61%)
		Ricin_B_lectin	506..627	CDD:306998	39/127 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152462
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D606683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750