DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pgant9 and gly-5

DIOPT Version :9

Sequence 1:	NP_001097342.1	Gene:	Pgant9 / 246627	FlyBaseID:	FBgn0050463	Length:	650	Species:	Drosophila melanogaster
Sequence 2:	NP_001379253.1	Gene:	gly-5 / 176736	WormBaseID:	WBGene00001630	Length:	626	Species:	Caenorhabditis elegans

Alignment Length:	661	Identity:	355/661 - (53%)
Similarity:	441/661 - (66%)	Gaps:	62/661 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IWRRRSTTIVKLVAFALAIWFCIAFLVYTDDTRRRAAQEGAGASGAGSAPGVGGGAGGLGDPIAL 68
            |:::::  |:|::......|.|  .|::...|...::|.|:.              ..|.:.||.
Worm     3 IFKKKA--ILKVLLLVPVFWIC--SLIFFAATSNDSSQIGSN--------------NDLANKIAE 49

  Fly    69 ALRNEPAGEDFGINGNVIGGGGQKQAHDEADIPPTVGKHKADLQAERMRKKAAEQP---KKKPQE 130
            |..:..|.:.     :||.|.|          ||.    :.:...|..:.:..|||   ..||
Worm    50 ANFHPKAAKQ-----DVIQGFG----------PPI----EPEPVVENNKVEEEEQPGGNLAKP-- 93

  Fly   131 DSKKVIDPPANFEENP----------GELGKPVRLPK-EMSDEMKKAVDDGWTKNAFNQYVSDLI 184
              |.::||     .:|          |||||.|.:.| ::|.|.|...|.|...||||||.||:|
Worm    94 --KFMVDP-----NDPIYKKGDAAQAGELGKAVVVDKTKLSTEEKAKYDKGMLNNAFNQYASDMI 151

  Fly   185 SVHRTLPDPRDAWCKDEARYLTNLPKTDVIICFHNEAWTVLLRTVHSVLDRSPEHLIGKIILVDD 249
            |||||||...||.||.| :|..|||:|.||||||||||:||||||||||:|:|:||:.:::||||
Worm   152 SVHRTLPTNIDAECKTE-KYNENLPRTSVIICFHNEAWSVLLRTVHSVLERTPDHLLEEVVLVDD 215

  Fly   250 YSDMPHLKRQLEDYFAAY-PKVQIIRGQKREGLIRARILGANHAKSPVLTYLDSHCECTEGWLEP 313
            :|||.|.||.||:|.:.: .||:|:|.:|||||||||:.||..|...|||||||||||.|||:||
Worm   216 FSDMDHTKRPLEEYMSQFGGKVKILRMEKREGLIRARLRGAAVATGEVLTYLDSHCECMEGWMEP 280

  Fly   314 LLDRIARNSTTVVCPVIDVISDETLEYHYRDSGGVNVGGFDWNLQFSWHPVPERERKRHNSTAEP 378
            |||||.|:.|||||||||||.|.|.|||:..:...:||||||.|||:||.:|||:||......:|
Worm   281 LLDRIKRDPTTVVCPVIDVIDDNTFEYHHSKAYFTSVGGFDWGLQFNWHSIPERDRKNRTRPIDP 345

  Fly   379 VYSPTMAGGLFSIDREFFDRLGTYDSGFDIWGGENLELSFKTWMCGGTLEIVPCSHVGHIFRKRS 443
            |.||||||||||||:::|::|||||.|||||||||||||||.|||||||||||||||||:|||||
Worm   346 VRSPTMAGGLFSIDKKYFEKLGTYDPGFDIWGGENLELSFKIWMCGGTLEIVPCSHVGHVFRKRS 410

  Fly   444 PYKWRSGVNVLKKNSVRLAEVWMDEYSQYYYHRIGNDKGDWGDVSDRRKLRNDLKCKSFKWYLDN 508
            |||||:||||||:||:||||||:|:|..|||.||.|..||:||:|.|:|||.||.||||||||||
Worm   411 PYKWRTGVNVLKRNSIRLAEVWLDDYKTYYYERINNQLGDFGDISSRKKLREDLGCKSFKWYLDN 475

  Fly   509 IYPELFIPGDSVAHGEIRNLGYGGRTCLDAPAGKKHQKKAVGTYPCHRQGGNQYWMLSKAGEIRR 573
            ||||||:||:|||.||:||.......|||...|:..:.:.||||.||.|||||||||||.|||||
Worm   476 IYPELFVPGESVAKGEVRNSAVQPARCLDCMVGRHEKNRPVGTYQCHGQGGNQYWMLSKDGEIRR 540

  Fly   574 DDSCLDYAGKDVTLFGCHGGKGNQFWTYRENTKQLHHGTSGKCLAISESKDKLLMEECSASLSRQ 638
            |:||:||||.||.:|.|||.||||.|.|..:|.:|.|..|.|||.:::...||.|..|......|
Worm   541 DESCVDYAGSDVMVFPCHGMKGNQEWRYNHDTGRLQHAVSQKCLGMTKDGAKLEMVACQYDDPYQ 605

  Fly   639 QWTLENYDSSK 649
            .|..:.|:.:|
Worm   606 HWKFKEYNEAK 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant9	NP_001097342.1	WcaA	207..>478	CDD:223539	193/271 (71%)
		pp-GalNAc-T	213..510	CDD:133004	212/297 (71%)
		Ricin_B_lectin	521..640	CDD:279046	62/118 (53%)
		RICIN	523..642	CDD:238092	62/118 (53%)
gly-5	NP_001379253.1	pp-GalNAc-T	178..477	CDD:133004	212/298 (71%)
gly-5	NP_001379253.1	Ricin_B_lectin	488..607	CDD:395527	62/118 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166314
Domainoid	1	1.000	260	1.000	Domainoid score	I1066
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H71043
Inparanoid	1	1.050	691	1.000	Inparanoid score	I357
Isobase	1	0.950	-	0.721928	Normalized mean entropy	S3838
OMA	1	1.010	-	-		QHG52215
OrthoDB	1	1.010	-	-		D153577at33208
OrthoFinder	1	1.000	-	-		FOG0002384
OrthoInspector	1	1.000	-	-		oto20665
orthoMCL	1	0.900	-	-		OOG6_102903
Panther	1	1.100	-	-	LDO	PTHR11675
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R16892
SonicParanoid	1	1.000	-	-		X13601
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.890