DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pgant9 and Galnt10

DIOPT Version :9

Sequence 1:	NP_001097342.1	Gene:	Pgant9 / 246627	FlyBaseID:	FBgn0050463	Length:	650	Species:	Drosophila melanogaster
Sequence 2:	NP_598950.2	Gene:	Galnt10 / 171212	MGIID:	1890480	Length:	603	Species:	Mus musculus

Alignment Length:	682	Identity:	272/682 - (39%)
Similarity:	358/682 - (52%)	Gaps:	123/682 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RRRSTTIVKLVAFALAIWFCIAFLVYTDDTRRRAAQEGAGASGAGSAPGVG-----------GGA 59
            ||:...:::.||.|||....:                          |.||           |..
Mouse     2 RRKEKRLLQAVALALAALVLL--------------------------PNVGLWALYRERQPDGSP 40

  Fly    60 GGLGDPIALALRNEPAGEDFGINGNVIGGGGQKQAHDEADIPPTVGKHKADLQAERMRKKAAEQP 124
            ||||..:|      ||              ..::.|...       |....|.||:..|.  ...
Mouse    41 GGLGAAVA------PA--------------AVQELHSRQ-------KKTFFLGAEQRLKD--WHN 76

  Fly   125 KKKPQEDSKKVIDPPANFEENPGELGKPVRLPKEMSDEMKKAVDDGWTKNAFNQYVSDLISVHRT 189
            |:..:.|:::|         ..||.|||.    .|:|  .:.||..:.:|.||.||||.||::|:
Mouse    77 KEAIRRDAQRV---------GYGEQGKPY----PMTD--AERVDQAYRENGFNIYVSDKISLNRS 126

  Fly   190 LPDPRDAWCKDEARYLTNLPKTDVIICFHNEAWTVLLRTVHSVLDRSPEHLIGKIILVDDYSDMP 254
            |||.|...|..:. ||..||.|.:||.||||.|:.|||||||||:|||..|:.:|:||||:||..
Mouse   127 LPDIRHPNCNSKL-YLETLPNTSIIIPFHNEGWSSLLRTVHSVLNRSPPELVAEIVLVDDFSDRE 190

  Fly   255 HLKRQLEDYFAAYPKVQIIRGQKREGLIRARILGANHAKSPVLTYLDSHCECTEGWLEPLLDRIA 319
            |||:.||||.|.:|.|:|:|.:|||||||.|:|||:.|...|:|:||||||....||.|||||||
Mouse   191 HLKKPLEDYMALFPSVRILRTKKREGLIRTRMLGASAATGDVVTFLDSHCEANVNWLPPLLDRIA 255

  Fly   320 RNSTTVVCPVIDVISDETLEYHYRDSGGVNVGGFDWNLQFSWHPVPERERKRHNSTAEPVYSPTM 384
            ||..|:|||:||||..:...|. ..:|....|.|||.:.:...|:|...:|...|  :|..||.|
Mouse   256 RNRKTIVCPMIDVIDHDDFRYE-TQAGDAMRGAFDWEMYYKRIPIPPELQKADPS--DPFESPVM 317

  Fly   385 AGGLFSIDREFFDRLGTYDSGFDIWGGENLELSFKTWMCGGTLEIVPCSHVGHIFRKRSPYKWRS 449
            |||||::||::|..||.||.|.:|||||..|:|||.|||||.:|.:|||.||||:||..|||..:
Mouse   318 AGGLFAVDRKWFWELGGYDPGLEIWGGEQYEISFKVWMCGGRMEDIPCSRVGHIYRKYVPYKVPA 382

  Fly   450 GVNVLKKNSVRLAEVWMDEYSQYYYHRIGNDKGDW-----GDVSDRRKLRNDLKCKSFKWYLDNI 509
            ||: |.:|..|:||||||||::|.|.|    :.::     |||..::|||..|.||||||::..|
Mouse   383 GVS-LARNLKRVAEVWMDEYAEYIYQR----RPEYRHLSAGDVVAQKKLRVSLNCKSFKWFMTKI 442

  Fly   510 -------YPELFIPGDSVAHGEIRNLGYGGRTCLDAPAGKKHQKKAVGTYPCHRQGGNQYW---- 563
                   ||.:..|  :.|.|||||:|.|  .|.|...|.......:.|  |.|..|...|
Mouse   443 AWDLPKFYPPVEPP--AAAWGEIRNVGTG--LCTDTKLGTLGSPLRLET--CIRGRGEAAWNSMQ 501

  Fly   564 --MLSKAGEIRRDDS------CLDYAG--KDVTLFGCHGGKGNQFWTYRENTKQLHHGTSGKCLA 618
              ..:...:||..|.      |.|...  ..|||:.||..||||.|.||:: |.|:|..||.|:.
Mouse   502 VFTFTWREDIRPGDPQHTKKFCFDAVSHTSPVTLYDCHSMKGNQLWKYRKD-KTLYHPVSGSCMD 565

  Fly   619 ISESKDKLLMEECSASLSRQQWTLENYDSSKL 650
            .|||..::.|..|:.|...|||..|:.:|:.|
Mouse   566 CSESDHRVFMNTCNPSSLTQQWLFEHTNSTVL 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant9	NP_001097342.1	WcaA	207..>478	CDD:223539	151/270 (56%)
		pp-GalNAc-T	213..510	CDD:133004	162/308 (53%)
		Ricin_B_lectin	521..640	CDD:279046	46/132 (35%)
		RICIN	523..642	CDD:238092	47/132 (36%)
Galnt10	NP_598950.2	WcaA	144..443	CDD:223539	164/306 (54%)
		Catalytic subdomain A	144..253		67/108 (62%)
		pp-GalNAc-T	148..443	CDD:133004	161/302 (53%)
		Catalytic subdomain B	311..373		39/61 (64%)
		Flexible loop. /evidence=ECO:0000250	373..384		5/10 (50%)
		Ricin_B_lectin	459..587	CDD:279046	46/132 (35%)
		RICIN	461..589	CDD:238092	47/132 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842523
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740