Protein Alignment Pgant9 and GALNT15

DIOPT Version :10

• Sequence 1: NP_725602.1
• Gene: Pgant9 / 246627
• FlyBaseID: FBgn0050463
• Length: 650
• Species: Drosophila melanogaster
• Sequence 2: NP_473451.3
• Gene: GALNT15 / 117248
• HGNCID: 21531
• Length: 639
• Species: Homo sapiens
• Alignment Length: 627
• Identity: 210/627 - (33%)
• Similarity: 306/627 - (48%)
• Gaps: 83/627 - (13%)

  Fly    67 ALALRNEPAGE---DFGINGNVIGGGGQKQAHDEAD-------IPPTVGKHKADL-------QAE 114
            |.|.::.|...   |||.:.:.:     .:|.||.:       :||.:...:..|       ||.
Human    46 AQASKHSPEARYRLDFGESQDWV-----LEAEDEGEEYSPLEGLPPFISLREDQLLVAVALPQAR 105

  Fly   115 RMRK--------KAAEQPKKKPQEDSKKVIDPPANFEENPGELGKPVRLPKEMSDEMKKAVDDGW 171
            |.:.        :..:||:::.:|..|:  |..|   :..||:.:...|.....|
Human   106 RNQSQGRRGGSYRLIKQPRRQDKEAPKR--DWGA---DEDGEVSEEEELTPFSLD---------- 155

  Fly   172 TKNAFNQYVSDLISVHRTLPDPRDAWCKDEARYLTNLPKTDVIICFHNEAWTVLLRTVHSVLDRS 236
             .....:.:|..|.:.|.||:.|...|..: ....:||...||:|||:|||:.|||||||:||..
Human   156 -PRGLQEALSARIPLQRALPEVRHPLCLQQ-HPQDSLPTASVILCFHDEAWSTLLRTVHSILDTV 218

  Fly   237 PEHLIGKIILVDDYSDMPHLKRQLEDYFAAYPKVQIIRGQKREGLIRARILGANHAKSPVLTYLD 301
            |...:.:||||||.|....||..|.:|.|....|:::|..||.|.||||:|||..|...||.::|
Human   219 PRAFLKEIILVDDLSQQGQLKSALSEYVARLEGVKLLRSNKRLGAIRARMLGATRATGDVLVFMD 283

  Fly   302 SHCECTEGWLEPLLDRIARNSTTVVCPVIDVISDETLEYHYRDSGGVNVGGFDWNLQFSWHPVPE 366
            :||||..|||||||.|||.:.:.||.||||||..:|.:|:  .|..:..|..||.|.|.|.|:||
Human   284 AHCECHPGWLEPLLSRIAGDRSRVVSPVIDVIDWKTFQYY--PSKDLQRGVLDWKLDFHWEPLPE 346

  Fly   367 RERKRHNSTAEPVYSPTMAGGLFSIDREFFDRLGTYDSGFDIWGGENLELSFKTWMCGGTLEIVP 431
            ..||...|...|:.||.:.|.:.::||.:|...|.|||...:.||||||||||.|:|||::||:|
Human   347 HVRKALQSPISPIRSPVVPGEVVAMDRHYFQNTGAYDSLMSLRGGENLELSFKAWLCGGSVEILP 411

  Fly   432 CSHVGHIFRKR---SPYKWRSGVNVLKKNSVRLAEVWMDEYSQYYY----HRIGNDKGDWGDVSD 489
            ||.||||::.:   ||....:.:    :|.||:||.|:..:.:.:|    ......|.:..|..:
Human   412 CSRVGHIYQNQDSHSPLDQEATL----RNRVRIAETWLGSFKETFYKHSPEAFSLSKAEKPDCME 472

  Fly   490 RRKLRNDLKCKSFKWYLDNIYPELF--IPGDSVAHGEIRNLGYGGRTCLDAPAGKKHQKKAVGTY 552
            |.:|:..|.|::|.|:|.|:||||:  .|..|.: |::.|.|.|  .|.|..|........:...
Human   473 RLQLQRRLGCRTFHWFLANVYPELYPSEPRPSFS-GKLHNTGLG--LCADCQAEGDILGCPMVLA 534

  Fly   553 PCHRQGGNQYWMLSKAGEIR---RDDSCLDYAGKDVTLFGC-------HGGKGNQFWTYRENTKQ 607
            ||......||...:...||.   ....|.....:.|.|..|       |    .|.|.::|| ..
Human   535 PCSDSRQQQYLQHTSRKEIHFGSPQHLCFAVRQEQVILQNCTEEGLAIH----QQHWDFQEN-GM 594

  Fly   608 LHHGTSGKCL--AISESKDKLLMEECSASLSRQQWTLENYDS 647
            :.|..||||:  .:.|:...|.:..|... :||||..:..::
Human   595 IVHILSGKCMEAVVQENNKDLYLRPCDGK-ARQQWRFDQINA 635

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant9	NP_725602.1	tolA	<91..>134	CDD:236545	12/64 (19%)
		pp-GalNAc-T	213..510	CDD:133004	136/303 (45%)
		beta-trefoil_Ricin_Pgant9-like	518..643	CDD:467340	35/136 (26%)
GALNT15	NP_473451.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	106..155		10/53 (19%)
		Catalytic subdomain A	190..299		59/108 (55%)
		pp-GalNAc-T	194..493	CDD:133004	136/304 (45%)
		Catalytic subdomain B	358..420		34/61 (56%)
		beta-trefoil_Ricin_GALNT15	502..629	CDD:467320	34/135 (25%)