DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pgant9 and GALNT15

DIOPT Version :9

Sequence 1:	NP_001097342.1	Gene:	Pgant9 / 246627	FlyBaseID:	FBgn0050463	Length:	650	Species:	Drosophila melanogaster
Sequence 2:	NP_473451.3	Gene:	GALNT15 / 117248	HGNCID:	21531	Length:	639	Species:	Homo sapiens

Alignment Length:	627	Identity:	210/627 - (33%)
Similarity:	306/627 - (48%)	Gaps:	83/627 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 ALALRNEPAGE---DFGINGNVIGGGGQKQAHDEAD-------IPPTVGKHKADL-------QAE 114
            |.|.::.|...   |||.:.:.:     .:|.||.:       :||.:...:..|       ||.
Human    46 AQASKHSPEARYRLDFGESQDWV-----LEAEDEGEEYSPLEGLPPFISLREDQLLVAVALPQAR 105

  Fly   115 RMRK--------KAAEQPKKKPQEDSKKVIDPPANFEENPGELGKPVRLPKEMSDEMKKAVDDGW 171
            |.:.        :..:||:::.:|..|:  |..|   :..||:.:...|.....|
Human   106 RNQSQGRRGGSYRLIKQPRRQDKEAPKR--DWGA---DEDGEVSEEEELTPFSLD---------- 155

  Fly   172 TKNAFNQYVSDLISVHRTLPDPRDAWCKDEARYLTNLPKTDVIICFHNEAWTVLLRTVHSVLDRS 236
             .....:.:|..|.:.|.||:.|...|..: ....:||...||:|||:|||:.|||||||:||..
Human   156 -PRGLQEALSARIPLQRALPEVRHPLCLQQ-HPQDSLPTASVILCFHDEAWSTLLRTVHSILDTV 218

  Fly   237 PEHLIGKIILVDDYSDMPHLKRQLEDYFAAYPKVQIIRGQKREGLIRARILGANHAKSPVLTYLD 301
            |...:.:||||||.|....||..|.:|.|....|:::|..||.|.||||:|||..|...||.::|
Human   219 PRAFLKEIILVDDLSQQGQLKSALSEYVARLEGVKLLRSNKRLGAIRARMLGATRATGDVLVFMD 283

  Fly   302 SHCECTEGWLEPLLDRIARNSTTVVCPVIDVISDETLEYHYRDSGGVNVGGFDWNLQFSWHPVPE 366
            :||||..|||||||.|||.:.:.||.||||||..:|.:|:  .|..:..|..||.|.|.|.|:||
Human   284 AHCECHPGWLEPLLSRIAGDRSRVVSPVIDVIDWKTFQYY--PSKDLQRGVLDWKLDFHWEPLPE 346

  Fly   367 RERKRHNSTAEPVYSPTMAGGLFSIDREFFDRLGTYDSGFDIWGGENLELSFKTWMCGGTLEIVP 431
            ..||...|...|:.||.:.|.:.::||.:|...|.|||...:.||||||||||.|:|||::||:|
Human   347 HVRKALQSPISPIRSPVVPGEVVAMDRHYFQNTGAYDSLMSLRGGENLELSFKAWLCGGSVEILP 411

  Fly   432 CSHVGHIFRKR---SPYKWRSGVNVLKKNSVRLAEVWMDEYSQYYY----HRIGNDKGDWGDVSD 489
            ||.||||::.:   ||....:.:    :|.||:||.|:..:.:.:|    ......|.:..|..:
Human   412 CSRVGHIYQNQDSHSPLDQEATL----RNRVRIAETWLGSFKETFYKHSPEAFSLSKAEKPDCME 472

  Fly   490 RRKLRNDLKCKSFKWYLDNIYPELF--IPGDSVAHGEIRNLGYGGRTCLDAPAGKKHQKKAVGTY 552
            |.:|:..|.|::|.|:|.|:||||:  .|..|.: |::.|.|.|  .|.|..|........:...
Human   473 RLQLQRRLGCRTFHWFLANVYPELYPSEPRPSFS-GKLHNTGLG--LCADCQAEGDILGCPMVLA 534

  Fly   553 PCHRQGGNQYWMLSKAGEIR---RDDSCLDYAGKDVTLFGC-------HGGKGNQFWTYRENTKQ 607
            ||......||...:...||.   ....|.....:.|.|..|       |    .|.|.::|| ..
Human   535 PCSDSRQQQYLQHTSRKEIHFGSPQHLCFAVRQEQVILQNCTEEGLAIH----QQHWDFQEN-GM 594

  Fly   608 LHHGTSGKCL--AISESKDKLLMEECSASLSRQQWTLENYDS 647
            :.|..||||:  .:.|:...|.:..|... :||||..:..::
Human   595 IVHILSGKCMEAVVQENNKDLYLRPCDGK-ARQQWRFDQINA 635

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant9	NP_001097342.1	WcaA	207..>478	CDD:223539	128/277 (46%)
		pp-GalNAc-T	213..510	CDD:133004	136/303 (45%)
		Ricin_B_lectin	521..640	CDD:279046	32/130 (25%)
		RICIN	523..642	CDD:238092	34/130 (26%)
GALNT15	NP_473451.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	106..155		10/53 (19%)
		Catalytic subdomain A	190..299		59/108 (55%)
		Glyco_tranf_2_3	191..447	CDD:290369	126/261 (48%)
		pp-GalNAc-T	194..493	CDD:133004	136/304 (45%)
		Catalytic subdomain B	358..420		34/61 (56%)
		Ricin_B_lectin	505..628	CDD:279046	32/131 (24%)
		RICIN	507..630	CDD:238092	34/130 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152452
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D606683at2759
OrthoFinder	1	1.000	-	-		FOG0002384
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.750