Protein Alignment Pgant9 and GALNT5

DIOPT Version :10

• Sequence 1: NP_725602.1
• Gene: Pgant9 / 246627
• FlyBaseID: FBgn0050463
• Length: 650
• Species: Drosophila melanogaster
• Sequence 2: XP_016858726.1
• Gene: GALNT5 / 11227
• HGNCID: 4127
• Length: 956
• Species: Homo sapiens
• Alignment Length: 601
• Identity: 228/601 - (37%)
• Similarity: 322/601 - (53%)
• Gaps: 102/601 - (16%)

  Fly    93 QAHDEADIPPTVGKHKADLQAERMRKKAAEQPKKKPQEDSKKVIDPPANFEENPGELGKPVRLP- 156
            |:|.:|.:|...|.|:.      :|......|:           ||.|     ||:.|:||.:|
Human   407 QSHIKALLPEDSGTHQV------LRIDVTLSPR-----------DPKA-----PGQFGRPVVVPH 449

  Fly   157 -KEMSDEMKKAVDDGWTKNAFNQYVSDLISVHRTLPDPRDAWCKDEARYLTNLPKTDVIICFHNE 220
             ||...|.:      |.:..||.|:||||.|.|.:.|.|.|.|.::..: .|||.|.||:||.:|
Human   450 GKEKEAERR------WKEGNFNVYLSDLIPVDRAIEDTRPAGCAEQLVH-NNLPTTSVIMCFVDE 507

  Fly   221 AWTVLLRTVHSVLDRSPEHLIGKIILVDDYSDMPHLKRQLEDYFAAYPKVQIIRGQKREGLIRAR 285
            .|:.|||:||||::|||.|||.:|:||||:|...:||..|:.|.:.:|||:|:|.::|.||||||
Human   508 VWSTLLRSVHSVINRSPPHLIKEILLVDDFSTKDYLKDNLDKYMSQFPKVRILRLKERHGLIRAR 572

  Fly   286 ILGANHAKSPVLTYLDSHCECTEGWLEPLLDRIARNSTTVVCPVIDVISDETLEYHYRDSGGVNV 350
            :.||.:|...|||:||||.||..|||||||:|:..:...|.||||:||:|:.:.|...|:  ...
Human   573 LAGAQNATGDVLTFLDSHVECNVGWLEPLLERVYLSRKKVACPVIEVINDKDMSYMTVDN--FQR 635

  Fly   351 GGFDWNLQFSWHPVP----ERERKRHNSTAEPVYSPTMAGGLFSIDREFFDRLGTYDSGFDIWGG 411
            |.|.|.:.|.|..:|    .:.|.:...|   :..|.|||||||||:.:|..|||||.|.|:|||
Human   636 GIFVWPMNFGWRTIPPDVIAKNRIKETDT---IRCPVMAGGLFSIDKSYFFELGTYDPGLDVWGG 697

  Fly   412 ENLELSFKTWMCGGTLEIVPCSHVGHIFRKRSPYKW-RSGVNVLKKNSVRLAEVWMDEYSQYYY- 474
            ||:|||||.|||||.:||:|||.||||||..:||.: :..:..:::|.||:||||:|||.:.:|
Human   698 ENMELSFKVWMCGGEIEIIPCSRVGHIFRNDNPYSFPKDRMKTVERNLVRVAEVWLDEYKELFYG 762

  Fly   475 ---HRIGNDKG-DWGDVSDRRKLRNDLKCKSFKWYLDNIYPELFIPGDSVAHGEIRNLGYGGRTC 535
               |.|  |:| |.|:::.:|:||..||||||||||:|::|:|..| ...|.|.:.|:..|  .|
Human   763 HGDHLI--DQGLDVGNLTQQRELRKKLKCKSFKWYLENVFPDLRAP-IVRASGVLINVALG--KC 822

  Fly   536 L----------DAPAGKKHQ----------------------KKAVGTYPCHRQGGNQYWMLSKA 568
            :          |....|:.|                      |.||..:||..:.....|:....
Human   823 ISIENTTVILEDCDGSKELQQFNYTWLRLIKCGEWCIAPIPDKGAVRLHPCDNRNKGLKWLHKST 887

  Fly   569 G----EIRRDDSCLDYAGKDVTLFGCHGGKGNQFWTYRENTKQLHHGTSGKCLAISESKDKLLME 629
            .    |:..:.:|..:... ::|...|        ...||.:||      .||..:.|:..|.:.
Human   888 SVFHPELLSNSACGSFPAL-LSLQVNH--------IVFENNQQL------LCLEGNFSQKILKVA 937

  Fly   630 ECSASLSRQQWTLENY 645
            .|......|:|..|.|
Human   938 ACDPVKPYQKWKFEKY 953

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant9	NP_725602.1	tolA	<91..>134	CDD:236545	8/40 (20%)
		pp-GalNAc-T	213..510	CDD:133004	156/306 (51%)
		beta-trefoil_Ricin_Pgant9-like	518..643	CDD:467340	29/160 (18%)
GALNT5	XP_016858726.1	pp-GalNAc-T	499..800	CDD:133004	156/307 (51%)
		beta-trefoil_Ricin_GALNT5	806..954	CDD:467314	32/166 (19%)