DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pgant9 and Galnt16

DIOPT Version :9

Sequence 1:	NP_001097342.1	Gene:	Pgant9 / 246627	FlyBaseID:	FBgn0050463	Length:	650	Species:	Drosophila melanogaster
Sequence 2:	NP_001074890.1	Gene:	Galnt16 / 108760	MGIID:	1917754	Length:	558	Species:	Mus musculus

Alignment Length:	651	Identity:	242/651 - (37%)
Similarity:	319/651 - (49%)	Gaps:	121/651 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 KLVAFALAI----WFCIAFLVYTDDTRRRAA-QEGAGASGAGSAPGVGGGAGGLGDPIALALRNE 73
            |:.|.|:||    |....|.....|.|..|| ..|.||..||..|                   |
Mouse     3 KIRANAIAILTVAWILGTFYYLWQDNRAHAASSSGRGAQRAGGRP-------------------E 48

  Fly    74 PAGEDFGINGNVIGGGGQKQAHDEADIPPTVGKHKADLQAERMRKKAAEQPKKKPQEDSKKVIDP 138
            ...||..|  .:|..|...:..||          ||.|.|::::
Mouse    49 QLREDRTI--PLIVTGTPSKGFDE----------KAYLSAKQLK--------------------- 80

  Fly   139 PANFEENPGELGKPVRLPKEMSDEMKKAVDDGWTKNAFNQYVSDLISVHRTLPDPRDAWCKDEAR 203
                   |||                    |.:.::||||..||.:|..|.:.|.|...| ....
Mouse    81 -------PGE--------------------DPYRQHAFNQLESDKLSSDRPIRDTRHYSC-PSLS 117

  Fly   204 YLTNLPKTDVIICFHNEAWTVLLRTVHSVLDRSPEHLIGKIILVDDYSDMPHLKRQLED--YFAA 266
            |.::||.|.|||.|||||.:.|||||.|||:|:|..||.:||||||:|..|      ||  ....
Mouse   118 YSSDLPATSVIITFHNEARSTLLRTVKSVLNRTPASLIQEIILVDDFSSDP------EDCLLLTR 176

  Fly   267 YPKVQIIRGQKREGLIRARILGANHAKSPVLTYLDSHCECTEGWLEPLLDRIARNSTTVVCPVID 331
            .|||:.:|..|||||||:|:.||:.|.:.|||:||||||....||:|:|.|:..:.|.||.|:||
Mouse   177 IPKVKCLRNDKREGLIRSRVRGADVAGATVLTFLDSHCEVNVEWLQPMLQRVMEDHTRVVSPIID 241

  Fly   332 VISDETLEYHYRDSGGVNVGGFDWNLQFSWHPVPERERKRHNSTAEPVYSPTMAGGLFSIDREFF 396
            |||.:...| ...|..:. |||||:|.|.|..:|..::.......:|:.:|.:|||:|.||:.:|
Mouse   242 VISLDNFAY-LAASADLR-GGFDWSLHFKWEQIPLEQKMTRTDPTKPIRTPVIAGGIFVIDKSWF 304

  Fly   397 DRLGTYDSGFDIWGGENLELSFKTWMCGGTLEIVPCSHVGHIFRKRSPYKWRSGVNVLK--KNSV 459
            :.||.||:..|||||||.||||:.|||||:|||||||.|||:||||.||.:..| |.|.  :|:.
Mouse   305 NHLGKYDAQMDIWGGENFELSFRVWMCGGSLEIVPCSRVGHVFRKRHPYNFPEG-NALTYIRNTK 368

  Fly   460 RLAEVWMDEYSQYYYHRIGNDKGD-WGDVSDRRKLRNDLKCKSFKWYLDNIYPELFIPGDSVAHG 523
            |.||||||||.||||....:..|. :|.|:.|.:.|..:.||||:|||:|:||||.:|...|..|
Mouse   369 RTAEVWMDEYKQYYYEARPSAIGKAFGSVATRIEQRKKMDCKSFRWYLENVYPELTVPVKEVLPG 433

  Fly   524 EIRNLGYGGRTCLDAPAGKKHQKKAVGTYPCHRQGGN----QYWMLSKAGEIRRDDSCL------ 578
            .|:.    |..||::..........:|...|.....:    |.|:.|. ..|::...||
Mouse   434 VIKQ----GVNCLESQGQNTAGDLLLGMGICRGSAKSPPPAQAWLFSD-HLIQQQGKCLAATSTL 493

  Fly   579 -DYAGKDVTLFGCHGGKGNQFWTYRENTKQLHHGTSGKCLAISESKD-KLLMEECSASLSRQQWT 641
             ...|..|.|..|:..:|.|.|  |.....:.|..||.||   |:|. :|:..:|......|||.
Mouse   494 MSSPGSPVILQTCNPKEGKQKW--RRKGSFIQHSVSGLCL---ETKPAQLVTSKCQTDAQAQQWQ 553

  Fly   642 L 642
            |
Mouse   554 L 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant9	NP_001097342.1	WcaA	207..>478	CDD:223539	144/274 (53%)
		pp-GalNAc-T	213..510	CDD:133004	154/301 (51%)
		Ricin_B_lectin	521..640	CDD:279046	31/130 (24%)
		RICIN	523..642	CDD:238092	33/130 (25%)
Galnt16	NP_001074890.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	34..53		7/37 (19%)
		Catalytic subdomain A	122..227		61/110 (55%)
		pp-GalNAc-T	126..420	CDD:133004	154/302 (51%)
		Catalytic subdomain B	286..348		39/61 (64%)
		Ricin_B_lectin	441..552	CDD:306998	28/116 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842506
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52215
OrthoDB	1	1.010	-	-		D606683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.760