DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30458 and XIRP1

DIOPT Version :9

Sequence 1:	NP_725663.1	Gene:	CG30458 / 246624	FlyBaseID:	FBgn0050458	Length:	145	Species:	Drosophila melanogaster
Sequence 2:	NP_919269.2	Gene:	XIRP1 / 165904	HGNCID:	14301	Length:	1843	Species:	Homo sapiens

Alignment Length:	148	Identity:	37/148 - (25%)
Similarity:	53/148 - (35%)	Gaps:	48/148 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 SEPAAGGYDYPQPAPPAPVKSYIPPPPPPP-----PPAP-----------------KNTYIPPPA 61
            |.|.|.|      |.|.|..:::||||..|     |..|                 |:..:...:
Human  1238 SGPQAAG------ASPHPHNAFVPPPPTLPAAVTGPDFPAGAHRAEDSIQQASEPLKDPLLHSHS 1296

  Fly    62 APAKAYIP-------PPPPPPPPAPKNTYIPPAPAPVAPVETYIPPAAPAPAYIPPAPVQAEEPI 119
            :||....|       |...|..|..|...:||.||.:  .:::.|...|.|  :|.:|..:.|..
Human  1297 SPAGQRTPGGSQTKTPKLDPTMPPKKKPQLPPKPAHL--TQSHPPQRLPKP--LPLSPSFSSEVG 1357

  Fly   120 IEE---------IEQPAQ 128
            ..|         |.|||:
Human  1358 QREHQRGERDTAIPQPAK 1375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30458	NP_725663.1	GYR	128..145	CDD:128953	0/1 (0%)
XIRP1	NP_919269.2	Interaction with VASP. /evidence=ECO:0000269\|PubMed:16631741	1..54
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..48
		Xin 1	89..104
		Xin 2	121..136
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	132..151
		Xin 3	151..166
		Xin	152..165	CDD:285310
		Xin 4	186..201
		Xin 5	226..241
		Xin 6	264..279
		Xin 7	302..317
		Xin	303..316	CDD:285310
		Xin 8	340..355
		Xin 9	376..391
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	406..432
		Xin 10	436..451
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	455..479
		Xin 11	507..522
		Xin	508..521	CDD:285310
		Interaction with CTNNB1. /evidence=ECO:0000250	531..632
		Xin	546..559	CDD:285310
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	564..591
		Xin	590..603	CDD:285310
		Xin 14	621..636
		Xin 15	654..669
		Xin 16	691..706
		Xin 17	723..738
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	943..999
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1063..1205
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1238..1277		14/44 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1289..1471		22/91 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1561..1696
		Interaction with FLNC. /evidence=ECO:0000269\|PubMed:16631741	1685..1843
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28KU4
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900