DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tdc2 and AAS

DIOPT Version :9

Sequence 1:	NP_724489.1	Gene:	Tdc2 / 246620	FlyBaseID:	FBgn0050446	Length:	637	Species:	Drosophila melanogaster
Sequence 2:	NP_849999.1	Gene:	AAS / 816553	AraportID:	AT2G20340	Length:	490	Species:	Arabidopsis thaliana

Alignment Length:	492	Identity:	228/492 - (46%)
Similarity:	306/492 - (62%)	Gaps:	28/492 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDSTEFRKRGMEMVEYICNYLETLNERRVTPSVEPGYLRHLLPPEAPQEPEDWDQIMRDVEDKIM 65
            |||.:.|:.|..||::|.:|.:|:.:..|...|:||||..|||..||..||..||::.||..||:
plant    12 MDSEQLREYGHLMVDFIADYYKTIEDFPVLSQVQPGYLHKLLPDSAPDHPETLDQVLDDVRAKIL 76

  Fly    66 PGVTHWQHPRFHAYFPAGNSFPSILGDMLGDGIGCIGFSWAASPACTELETIVLDWLGKAIGLPD 130
            |||||||.|.|.||:|:.:|....||:||..|:|.:||||..|||.||||.|||||:.|.:.||:
plant    77 PGVTHWQSPSFFAYYPSNSSVAGFLGEMLSAGLGIVGFSWVTSPAATELEMIVLDWVAKLLNLPE 141

  Fly   131 HFLALKEGSTGGGVIQTSASECVLVTMLAARAQALKRLKAQHPFVEEGHLLSKLMAYCSKEAHSC 195
            .|::  :|: ||||||.||||.|||.::|||.:.|:.:..        :.|.||:.|.|.:.||.
plant   142 QFMS--KGN-GGGVIQGSASEAVLVVLIAARDKVLRSVGK--------NALEKLVVYSSDQTHSA 195

  Fly   196 VEKAAMICFV---KLRILEPDDDA--SLRGQTIYEAMEEDELQGLVPFFVSTTLGTTGSCAFDNL 255
            ::||..|..:   ..|:|..|...  :||.:::.||:..|...||:|||:...:|||.|.|.|.|
plant   196 LQKACQIAGIHPENCRVLTTDSSTNYALRPESLQEAVSRDLEAGLIPFFLCANVGTTSSTAVDPL 260

  Fly   256 PEIGKQLQRFPGVWLHVDAAYAGNSFICPELKPLLKGIEYADSFNTNPNKWLLTNFDCSTLWVRD 320
            ..:|| :....|:|.||||||||::.||||.:..:.|:|.|||||.|.:||.|||||||.|||:|
plant   261 AALGK-IANSNGIWFHVDAAYAGSACICPEYRQYIDGVETADSFNMNAHKWFLTNFDCSLLWVKD 324

  Fly   321 RIRLTSALVVDPLYLKHGYSDA--AIDYRHWGVPLSRRFRSLKLWFVLRSYGISGLQHYIRHHIK 383
            :..||.||..:|.:||:..|.|  .:||:.|.:||.|||||||||.|||.||...|:.|||:|||
plant   325 QDSLTLALSTNPEFLKNKASQANLVVDYKDWQIPLGRRFRSLKLWMVLRLYGSETLKSYIRNHIK 389

  Fly   384 LAKRFEELVLKDKRFEICNQVKLGLVCFRL-------KGSDKLNEKLLSIINESGKLHMVPASVG 441
            |||.||:||.:|..|||.......||||||       |..:..|.:||..:|.||||.|...::.
plant   390 LAKEFEQLVSQDPNFEIVTPRIFALVCFRLVPVKDEEKKCNNRNRELLDAVNSSGKLFMSHTALS 454

  Fly   442 DRYIIRFCAVAQNATAE-DIDYAWDIIVDFANELLEK 477
            .:.::| ||:....|.| .:..||.||.:.|:.||.|
plant   455 GKIVLR-CAIGAPLTEEKHVKEAWKIIQEEASYLLHK 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tdc2	NP_724489.1	Pyridoxal_deC	35..414	CDD:278699	193/392 (49%)
AAS	NP_849999.1	PLN02880	3..490	CDD:215475	227/490 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	368	1.000	Domainoid score	I180
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	417	1.000	Inparanoid score	I444
OMA	1	1.010	-	-		QHG57772
OrthoDB	1	1.010	-	-		D856958at2759
OrthoFinder	1	1.000	-	-		FOG0000865
OrthoInspector	1	1.000	-	-		mtm1068
orthoMCL	1	0.900	-	-		OOG6_100572
Panther	1	1.100	-	-	O	PTHR11999
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X696
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840