DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tdc2 and hdc

DIOPT Version :9

Sequence 1:	NP_724489.1	Gene:	Tdc2 / 246620	FlyBaseID:	FBgn0050446	Length:	637	Species:	Drosophila melanogaster
Sequence 2:	XP_005169965.1	Gene:	hdc / 793609	ZFINID:	ZDB-GENE-080102-5	Length:	608	Species:	Danio rerio

Alignment Length:	547	Identity:	267/547 - (48%)
Similarity:	358/547 - (65%)	Gaps:	27/547 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDSTEFRKRGMEMVEYICNYLETLNERRVTPSVEPGYLRHLLPPEAPQEPEDWDQIMRDVEDKIM 65
            |...|:..||.||||||..||..:.||||.|.|:||::|.|||..||.|||||..||:|||:.||
Zfish     1 MQPQEYMLRGKEMVEYIHQYLTGIRERRVVPDVQPGFMRPLLPSSAPYEPEDWSTIMQDVENIIM 65

  Fly    66 PGVTHWQHPRFHAYFPAGNSFPSILGDMLGDGIGCIGFSWAASPACTELETIVLDWLGKAIGLPD 130
            |||.|||.|..||||||.||:||:|||||.|.|.|:||:||:||||||||..|||||.||:||||
Zfish    66 PGVVHWQSPHMHAYFPALNSWPSLLGDMLADAINCLGFTWASSPACTELEMCVLDWLCKALGLPD 130

  Fly   131 HFLALKEGSTGGGVIQTSASECVLVTMLAARAQALKRLK--AQHPFVEEGHLLSKLMAYCSKEAH 193
            |:|.....|||||::|::.|||.||.:||||...:.::|  |.|...:|..|.|:|:||.|.:||
Zfish   131 HYLHHHPQSTGGGILQSTVSECTLVALLAARKDRILQMKSEATHTDTDESVLNSRLVAYASDQAH 195

  Fly   194 SCVEKAAMICFVKLRILEPDDDASLRGQTIYEAMEEDELQGLVPFFVSTTLGTTGSCAFDNLPEI 258
            |.||||.:|..||:|.|:.|...||||:|:..|:|||...||:|..|..|||:||.|:||.|.|:
Zfish   196 SSVEKAGLISLVKIRFLQTDAVFSLRGETLQRAVEEDRRSGLIPVMVCATLGSTGVCSFDRLDEL 260

  Fly   259 GKQLQRFPGVWLHVDAAYAGNSFICPELKPLLKGIEYADSFNTNPNKWLLTNFDCSTLWVRDRIR 323
            |....| .|:||||||||||::.:||||:..|.||::||||..||:||:|.:|||:..||:::::
Zfish   261 GPVCVR-EGLWLHVDAAYAGSALLCPELRYFLDGIQFADSFVFNPSKWMLVHFDCTAFWVKNKMK 324

  Fly   324 LTSALVVDPLYLKHGYSDAAIDYRHWGVPLSRRFRSLKLWFVLRSYGISGLQHYIRHHIKLAKRF 388
            |.....||||||:|..|:|. |:.||.:||||||||||||||:||:|:..||.:|||.:::||.|
Zfish   325 LQQTFTVDPLYLRHDNSNAT-DFMHWQIPLSRRFRSLKLWFVIRSFGLKKLQEHIRHGVEMAKLF 388

  Fly   389 EELVLKDKRFEICNQVKLGLVCFRLKGSDKLNEKLLSIINESGKLHMVPASVGDRYIIRFCAVAQ 453
            |.||..|..|:|..|..||||.|.|:..:...::||..:..||::.::||:||::.|:||...:|
Zfish   389 ESLVRNDTHFQIPAQRHLGLVVFCLRAGNAATQELLRKLTRSGRMFLIPAAVGNQLILRFSVTSQ 453

  Fly   454 NATAEDIDYAWDIIVDFANELLEKEQHDELSEIMNRKKQDTLAQKRSFFVRMVSDPKIYNPAINK 518
            ..|.:||...|.:|...|.|:|:       |.::.|:...|            |||:....::..
Zfish   454 LTTEQDIRRDWSLIQQAAREVLQ-------SGVVTRQPSVT------------SDPESEPESLTI 499

  Fly   519 AGTPKLSMELPSPVVSRGSAPIIRTQS 545
            ...|.|...|    |.:|....:|:.|
Zfish   500 HTEPMLDQRL----VRQGQRRAVRSYS 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tdc2	NP_724489.1	Pyridoxal_deC	35..414	CDD:278699	215/380 (57%)
hdc	XP_005169965.1	Pyridoxal_deC	35..414	CDD:278699	215/380 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57772
OrthoDB	1	1.010	-	-		D223497at33208
OrthoFinder	1	1.000	-	-		FOG0000865
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100572
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X696
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.730