DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tdc2 and Gadl1

DIOPT Version :9

Sequence 1:	NP_724489.1	Gene:	Tdc2 / 246620	FlyBaseID:	FBgn0050446	Length:	637	Species:	Drosophila melanogaster
Sequence 2:	NP_001382689.1	Gene:	Gadl1 / 73748	MGIID:	1920998	Length:	522	Species:	Mus musculus

Alignment Length:	508	Identity:	130/508 - (25%)
Similarity:	221/508 - (43%)	Gaps:	70/508 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 KRGMEMVEYICNYL--------ETLNERRVTPSVEPGYLRHLLPPEAPQEPEDWDQIMRDVEDKI 64
            |.|.:.||..|..:        ..:|| :|.....|..||.||..|.....|..|::::..:|
Mouse    44 KAGEKFVEEACRLIMEEVVLKATDVNE-KVCEWQPPEQLRQLLDLEMRDTGESQDKLLKLCQD-- 105

  Fly    65 MPGVTHW----QHPRFHAYFPAGNSFPSILGDMLGDGIGCIGFSWAASPACTELETIVLDWLGKA 125
               |.|:    .||||.....||..:.|:...::.:.:....:::..||....:|..||..:.:.
Mouse   106 ---VIHFSVKTNHPRFFNQLYAGLDYYSLAARIITEALNPSIYTYEVSPVFLLVEEAVLKKMIEC 167

  Fly   126 IGLPDHFLALKEGSTGGGVIQTSASECVLVTMLAARAQALKRLKAQH-PFVEEGHL--LSKLMAY 187
            :|       .|||.   |:.....|...:..|..||        .:| |.::|..|  |.:|:.:
Mouse   168 VG-------WKEGD---GIFNPGGSVSNMCAMNLAR--------YRHCPDIKEKGLSGLPRLILF 214

  Fly   188 CSKEAHSCVEKAAMICFV---KLRILEPDDDASLRGQTIYEAMEED----ELQGLVPFFVSTTLG 245
            .|.|.|..::|||....:   .:..:|.|.    ||:.|.|.:|:.    ..:|.|||.|..|.|
Mouse   215 TSAECHYSMKKAASFLGIGTQNVYFVETDG----RGKMIPEDLEKQIWQARQEGAVPFLVCATSG 275

  Fly   246 TTGSCAFDNLPEIGKQLQRFPGVWLHVDAAYAGNSFICPELKPLLKGIEYADSFNTNPNKWLLTN 310
            ||...|||.|.||.:..:|. |:||||||::.|::.:..:.:.||.||..|||...||:|.|:..
Mouse   276 TTVLGAFDPLDEIAEVCERH-GLWLHVDASWGGSALVSRKHRRLLHGIHRADSVAWNPHKMLMAG 339

  Fly   311 FDCSTLWVRDR---IRLTSALVVDPLYLKHGYSDAAIDYRHWGVPLSRRFRSLKLWFVLRSYGIS 372
            ..||.|.|:|:   ::...:.....|:.:..:.|.:.|.....:..|||..:.|.|...::.|.|
Mouse   340 IQCSALLVKDKSDLLKKCYSAKATYLFQQDKFYDVSYDTGDKSIQCSRRPDAFKFWMTWKALGTS 404

  Fly   373 GLQHYIRHHIKLAKRFEELVLKDKRFEICNQVKLGLVCF-----RLKGSDKLNE--KLLSIINES 430
            ||:..:.....|::...:.:.|.:.|::..:.:...|||     .|:..::..|  :.||::..:
Mouse   405 GLEERVNRAFALSRYLVDEIKKREGFKLLMEPEYTNVCFWYIPPSLREMEEGPEFWRKLSLVAPA 469

  Fly   431 GKLHMVPASV---------GDRYIIRFCAVAQNATAEDIDYAWDIIVDFANEL 474
            .|..|:....         |.....|...::...:.||:|:..|.|.....::
Mouse   470 IKEKMMKKGSLMLGYQPHRGKVNFFRQVVISPQVSREDMDFLLDEIDSLGRDM 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tdc2	NP_724489.1	Pyridoxal_deC	35..414	CDD:278699	109/400 (27%)
Gadl1	NP_001382689.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835052
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740