DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tdc2 and gad2

DIOPT Version :9

Sequence 1:	NP_724489.1	Gene:	Tdc2 / 246620	FlyBaseID:	FBgn0050446	Length:	637	Species:	Drosophila melanogaster
Sequence 2:	NP_001017708.2	Gene:	gad2 / 550403	ZFINID:	ZDB-GENE-030909-9	Length:	583	Species:	Danio rerio

Alignment Length:	507	Identity:	132/507 - (26%)
Similarity:	206/507 - (40%)	Gaps:	78/507 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 EMVEYICNYL-ETLNERRVTPSVEPGYLRHLLPP---EAPQEPEDWDQIMRDVEDKIMPGVTHWQ 72
            |:|:.:..|: |:.:  |.|..::..|...||..   |...|||..|.|:......:...: ...
Zfish   111 EVVDILLAYIVESFD--RSTKVIDFHYPNELLQRNNWELSDEPETLDDILISCRATLKYAI-KTA 172

  Fly    73 HPRFHAYFPAGNSFPSILGDMLGDGIGCIGFSWAASPACTELETIVLDWLGKAIGLPDHFLALKE 137
            |||:......|.....:..|.|........|::..:|....||.:.|..:.:.||..|
Zfish   173 HPRYFNQLSTGLDMVGLAADWLTSTANTNMFTYEVAPVFVLLEYVTLKKMREIIGWQD------- 230

  Fly   138 GSTGGGVIQTSASECVLVTMLAARAQALKRLKAQHPFVEEG-HLLSKLMAYCSKEAHSCVEKAA- 200
             ..|.|:.....:...:..||.||.:....:|      |:| ..:.:|:|:.|:.:|..::|.|
Zfish   231 -GHGDGIFSPGGAISNMYAMLLARYKMFPEVK------EKGMSSVPRLVAFTSEHSHFSIKKGAA 288

  Fly   201 --------MICFVKLRILEPDDDASLRGQTIYEAME----EDELQGLVPFFVSTTLGTTGSCAFD 253
                    :||      ::.|:    ||:.|...:|    |.:.:|.||||||.|.|||...|||
Zfish   289 ALGIGTESVIC------IKADE----RGKMIPSDLERRIIEAKQKGYVPFFVSATAGTTVYGAFD 343

  Fly   254 NLPEIGKQLQRFPGVWLHVDAAYAGNSFICPELKPLLKGIEYADSFNTNPNKWLLTNFDCSTLWV 318
            .|..|....::. .||:|||.|:.|:..:..:.:..|.|:|.|:|...||:|.:.....||.|.|
Zfish   344 PLIAIADICKKH-DVWMHVDGAWGGSLLMSRKHRWKLNGVERANSMTWNPHKMMAVPLQCSALLV 407

  Fly   319 RDRIRLTSALVVDPLYL----KHGYSDAAIDYRHWGVPLSRRFRSLKLWFVLRSYGISGLQHYIR 379
            |:...:.|...:...||    ||  .|...|.....:...|.....|||.:.|:.|..|.:..|.
Zfish   408 REEGLMQSCNQMQACYLFQQDKH--YDLQYDTGDKALQCGRHVDIFKLWLMWRAKGTIGFEAQID 470

  Fly   380 HHIKLAKRFEELVLKDKRFEICNQVKLGL-----VCF---------------RLKGSDKLNEKLL 424
            ..::|:   |.|..|.|..|....|..|.     |||               |:|...|:...:.
Zfish   471 KCLELS---EYLYNKIKDREGYQMVFDGKPQHTNVCFWYLPPGVRYLEDKVERMKRLHKVAPVIK 532

  Fly   425 SIINESGKLHMVPASVGDRYIIRFCAVAQN--ATAEDIDYAWDIIVDFANEL 474
            :.:.|.|...:.....||: :..|..|..|  ||.||||:..:.|.....:|
Zfish   533 ARMMEYGTTMVSYQPQGDK-VNFFRMVISNPAATFEDIDFLIEEIERLGQDL 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tdc2	NP_724489.1	Pyridoxal_deC	35..414	CDD:278699	109/419 (26%)
gad2	NP_001017708.2	Pyridoxal_deC	136..506	CDD:278699	107/400 (27%)
gad2	NP_001017708.2	TIM_phosphate_binding	511..>561	CDD:304361	9/50 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578195
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740