Protein Alignment Tdc2 and CSAD

DIOPT Version :9

• Sequence 1: NP_724489.1
• Gene: Tdc2 / 246620
• FlyBaseID: FBgn0050446
• Length: 637
• Species: Drosophila melanogaster
• Sequence 2: XP_024304779.1
• Gene: CSAD / 51380
• HGNCID: 18966
• Length: 620
• Species: Homo sapiens
• Alignment Length: 530
• Identity: 132/530 - (24%)
• Similarity: 205/530 - (38%)
• Gaps: 109/530 - (20%)

  Fly     8 KRGMEMVEYICNYLETLNERRVTPSVEPGYLRHLLPPEAPQEPEDWDQIMRDVEDKIMPGVTHWQ 72
            ::|..:.:.:|.:            .||..|:.||..|...:.|...||:......|...| ...
Human   130 QKGTSVSQKVCEW------------KEPEELKQLLDLELRSQGESQKQILERCRAVIRYSV-KTG 181

  Fly    73 HPRFHAYFPAGNSFPSILGDMLGDGIGCIGFSWAASPACTELETIVLDWLGKAIGLPDHFLALKE 137
            ||||.....:|....::.|.::.:.:....:::..:|....:|..||..|...:|
Human   182 HPRFFNQLFSGLDPHALAGRIITESLNTSQYTYEIAPVFVLMEEEVLRKLRALVG---------- 236

  Fly   138 GSTGGGVIQTSASECVLVTMLAARAQALKRLKAQHPFVEEGHL--LSKLMAYCSKEA---HSCVE 197
            .|:|.|:.....|...:..:..||.|       ::|..::..|  |..|..:.|||.   |.  .
Human   237 WSSGDGIFCPGGSISNMYAVNLARYQ-------RYPDCKQRGLRTLPPLALFTSKEVGKRHR--P 292

  Fly   198 KAAMICFVKLRILEPD-------DDASL------------------RGQTI----------YEAM 227
            ...::..:...:..|.       |.|..                  ||:.:          :|..
Human   293 NPGLLILISSHVTTPSRRELRFWDLAPTVSEWSRLMREGKWSPRIWRGRLVWPRLRLTFHFFETF 357

  Fly   228 EEDELQGLVPFFVSTTLGTTGSCAFDNLPEIGKQLQRFPGVWLHVDAAYAGNSFICPELKPLLKG 292
            ..|  .|.|||.||.|.|||...|||.|..|....||. |:|||||||:.|:..:....:.||.|
Human   358 ILD--SGAVPFLVSATSGTTVLGAFDPLEAIADVCQRH-GLWLHVDAAWGGSVLLSQTHRHLLDG 419

  Fly   293 IEYADSFNTNPNKWLLTNFDCSTLWVRDRIRLTSALV-------VDPLYLKHGYSDAAIDYRHWG 350
            |:.|||...||:|.|.....||.|.::|    ||.|:       ...|:.:..:.|.|:|.....
Human   420 IQRADSVAWNPHKLLAAGLQCSALLLQD----TSNLLKRCHGSQASYLFQQDKFYDVALDTGDKV 480

  Fly   351 VPLSRRFRSLKLWFVLRSYGISGLQHYIRHHIKLAKRFEELVLKDKRFEICNQVKLGLVCF---- 411
            |...||...||||.:.::.|..||:..|.....||:...|.:.|.:.||:..:.:...|||
Human   481 VQCGRRVDCLKLWLMWKAQGDQGLERRIDQAFVLARYLVEEMKKREGFELVMEPEFVNVCFWFVP 545

  Fly   412 -RLKG---SDKLNEKLLSI-------INESGKLHMVPASVGDRYIIRFCAVAQNA-TAEDIDYAW 464
             .|:|   |...:|:|..:       :.:.|.:.:.....|.|.......||.:| |..|:|:
Human   546 PSLRGKQESPDYHERLSKVAPVLKERMVKEGSMMIGYQPHGTRGNFFRVVVANSALTCADMDF-- 608

  Fly   465 DIIVDFANEL 474
                 ..|||
Human   609 -----LLNEL 613

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tdc2	NP_724489.1	Pyridoxal_deC	35..414	CDD:278699	112/430 (26%)
CSAD	XP_024304779.1	DOPA_deC_like	185..616	CDD:99743	116/462 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810