DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tdc2 and Gad1

DIOPT Version :9

Sequence 1:	NP_724489.1	Gene:	Tdc2 / 246620	FlyBaseID:	FBgn0050446	Length:	637	Species:	Drosophila melanogaster
Sequence 2:	NP_001261396.1	Gene:	Gad1 / 38484	FlyBaseID:	FBgn0004516	Length:	510	Species:	Drosophila melanogaster

Alignment Length:	506	Identity:	124/506 - (24%)
Similarity:	212/506 - (41%)	Gaps:	63/506 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EFRKRGMEMVEYICNYLETLNER--RVTPSVEPGYLRHLLPPEAPQEPEDWDQIMRD----VEDK 63
            |.|:..:::::.:.::::..|:|  :|.....|..::.||..:.|.......|::.|    ::.:
  Fly    32 ETREFLLKVIDVLLDFVKATNDRNEKVLDFHHPEDMKRLLDLDVPDRALPLQQLIEDCATTLKYQ 96

  Fly    64 IMPGVTHWQHPRFHAYFPAGNSFPSILGDMLGDGIGCIGFSWAASPACTELETIVLDWLGKAIGL 128
            :..|     ||.|......|....|:.|:.|........|::..:|....:|.:||..:.:.||
  Fly    97 VKTG-----HPHFFNQLSNGLDLISMAGEWLTATANTNMFTYEIAPVFILMENVVLTKMREIIG- 155

  Fly   129 PDHFLALKEGSTGGGVIQTSASECVLVTMLAARAQALKRLKAQHPFVEEGHLLSKLMAYCSKEAH 193
                     .|.|..::....|...|...||||.:.....| :|..|   .|...|:.:.|.:.|
  Fly   156 ---------WSGGDSILAPGGSISNLYAFLAARHKMFPNYK-EHGSV---GLPGTLVMFTSDQCH 207

  Fly   194 SCVEKAAMICFVKLR--ILEPDDDASLRGQTIYEAME----EDELQGLVPFFVSTTLGTTGSCAF 252
            ..::..|.:|.:...  |:.|.|:   .|:.|...:|    |.:.:|.:||||:.|.|||...||
  Fly   208 YSIKSCAAVCGLGTDHCIVVPSDE---HGKMITSELERLILERKAKGDIPFFVNATAGTTVLGAF 269

  Fly   253 DNLPEIGKQLQRFPGVWLHVDAAYAGNSFICPELK-PLLKGIEYADSFNTNPNKWLLTNFDCSTL 316
            |::..|....|:: ..|:|:|||:.|...:..:.: |...|:|.|||...||:|.:.....|||:
  Fly   270 DDINTIADICQKY-NCWMHIDAAWGGGLLMSRKHRHPRFTGVERADSVTWNPHKLMGALLQCSTI 333

  Fly   317 WVRDRIRLTSA--LVVDPLYLKHGYSDAAIDYRHWGVPLSRRFRSLKLWFVLRSYGISGLQHYIR 379
            ..::...|.|.  :..:.|::.....|.:.|.....:...|.....|||...|:.|..|.:....
  Fly   334 HFKEDGLLISCNQMSAEYLFMTDKQYDISYDTGDKVIQCGRHNDIFKLWLQWRAKGTEGFEQQQD 398

  Fly   380 HHIKLA----KRFEELVLKDKRFEI-----CNQVKLGLVCFRLKG--SDKLNE----KLLSIIN- 428
            ..::|.    ||..|   :..||.:     |..|....|..||:|  .|...|    |:..||.
  Fly   399 RLMELVQYQLKRIRE---QSDRFHLILEPECVNVSFWYVPKRLRGVPHDAKKEVELGKICPIIKG 460

  Fly   429 ---ESGKLHMVPASVGDRYIIRFCAVAQNATAE--DIDYAWDIIVDFANEL 474
               :.|.| ||.....||....|.::..:|...  |:|:..|.|....::|
  Fly   461 RMMQKGTL-MVGYQPDDRRPNFFRSIISSAAVNEADVDFMLDEIHRLGDDL 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tdc2	NP_724489.1	Pyridoxal_deC	35..414	CDD:278699	99/400 (25%)
Gad1	NP_001261396.1	Pyridoxal_deC	64..434	CDD:395219	97/395 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445340
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0076
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740