Protein Alignment Tdc2 and Tdc1

DIOPT Version :10

• Sequence 1: NP_724489.1
• Gene: Tdc2 / 246620
• FlyBaseID: FBgn0050446
• Length: 637
• Species: Drosophila melanogaster
• Sequence 2: NP_610226.2
• Gene: Tdc1 / 35573
• FlyBaseID: FBgn0259977
• Length: 587
• Species: Drosophila melanogaster
• Alignment Length: 609
• Identity: 300/609 - (49%)
• Similarity: 383/609 - (62%)
• Gaps: 53/609 - (8%)

  Fly     1 MDSTEFRKRGMEMVEYICNYLETLNERRVTPSVEPGYLRHLLPPEAPQEPEDWDQIMRDVEDKIM 65
            ||..||||.|.|:::|||.|...:.||.|.|:::||||:.|||.:|||.||.:..::.|.|.|||
  Fly     1 MDVEEFRKYGKEVIDYICQYGTNIEERDVAPTLDPGYLKKLLPADAPQSPEPFKDVLEDFEQKIM 65

  Fly    66 PGVTHWQHPRFHAYFPAGNSFPSILGDMLGDGIGCIGFSWAASPACTELETIVLDWLGKAIGLPD 130
            |||.||.||:|.||||:||||||:|||||...||.||||||:.||..||||||::|..||:|||.
  Fly    66 PGVVHWNHPKFFAYFPSGNSFPSVLGDMLSSAIGSIGFSWASCPAAAELETIVMNWYAKALGLPK 130

  Fly   131 HFLALKEGSTGGGVIQTSASECVLVTMLAARAQALKRLKAQHPFVEEGHLLSKLMAYCSKEAHSC 195
            .|::...||||||.:|.||||||||:::.|||:|:..||.| ..|.:...|..|:||.|:||||.
  Fly   131 AFVSDAPGSTGGGALQGSASECVLVSLITARARAISELKGQ-TSVHDSVFLPSLIAYASREAHSS 194

  Fly   196 VEKAAMICFVKLRILEPDDDASLRGQTIYEAMEEDELQGLVPFFVSTTLGTTGSCAFDNLPEIGK 260
            ||||..:..|||||::.|:...:|...:.:|::.|...||.||||..|:||||.||||::.||||
  Fly   195 VEKATKMALVKLRIIDADEHGRMRVDLLRQAIQNDVNAGLTPFFVVATVGTTGGCAFDDITEIGK 259

  Fly   261 QLQRFPGVWLHVDAAYAGNSFICPELKPLLKGIEYADSFNTNPNKWLLTNFDCSTLWVRDRIRLT 325
            ..::...:|||||.||||||||.||::....|:||||||||||||.||||||.|.|||||.:.|.
  Fly   260 VCRQVSSIWLHVDGAYAGNSFILPEMRVFSAGLEYADSFNTNPNKLLLTNFDASALWVRDVMNLK 324

  Fly   326 SALVVDPLYLKHGYSDAAIDYRHWGVPLSRRFRSLKLWFVLRSYGISGLQHYIRHHIKLAKRFEE 390
            |||.|:||||:|.:. ..:||||:|:|||||||:||||||.|:|||.|||.|||:|:.|||:||.
  Fly   325 SALNVNPLYLRHEHL-TGVDYRHYGIPLSRRFRALKLWFVFRTYGIRGLQEYIRNHMALAKKFEM 388

  Fly   391 LVLKDKRFEICNQVKLGLVCFRLKGSDKLNEKLLSIINESGKLHMVPASVGDRYIIRFCAVAQNA 455
            ||.||:|||:.|.|.|||||||::..|:.|..||:.||.|||:||.||....||:||||...::|
  Fly   389 LVRKDERFEVRNDVHLGLVCFRMRTGDEPNHMLLAQINHSGKMHMTPAKFNGRYVIRFCVTYEHA 453

  Fly   456 TAEDIDYAWDIIVDFANELLEKEQHDELS-----EIMNRKKQDTLAQKRSFFVRMVSDPKIYNPA 515
            |.:||..||..|..||.|:|...|.:..|     |...|...:.||            |....|.
  Fly   454 TEKDILEAWTQIKCFAEEILRDHQLESSSVPTTPEGSERTSSEPLA------------PVAGKPP 506

  Fly   516 INKAGTPKLSMELP-SPVVSR------------GSAPII---------RTQSSVDHNSWISWPLA 558
            |.|..|...|:... :..:||            |..||:         ..|.:.|.|.
  Fly   507 IKKRLTRTKSLRFSFTRSISREQYQSQSEHLMDGCTPILVVDPKTLQENFQKAADDND------- 564

  Fly   559 FLFNSNNEEKGSNVSLRFRHLDTN 582
             ..|||...|..::|    .:||:
  Fly   565 -RNNSNGNVKLKDIS----DVDTD 583

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tdc2	NP_724489.1	Pyridoxal_deC	35..414	CDD:395219	227/378 (60%)
Tdc1	NP_610226.2	Pyridoxal_deC	35..412	CDD:395219	227/378 (60%)