DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tdc2 and Ddc

DIOPT Version :9

Sequence 1:	NP_724489.1	Gene:	Tdc2 / 246620	FlyBaseID:	FBgn0050446	Length:	637	Species:	Drosophila melanogaster
Sequence 2:	NP_724163.1	Gene:	Ddc / 35190	FlyBaseID:	FBgn0000422	Length:	510	Species:	Drosophila melanogaster

Alignment Length:	479	Identity:	248/479 - (51%)
Similarity:	337/479 - (70%)	Gaps:	4/479 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDSTEFRKRGMEMVEYICNYLETLNERRVTPSVEPGYLRHLLPPEAPQEPEDWDQIMRDVEDKIM 65
            |::.||:.....||::|..|||.:.||||.|.|:||||:.|:|..||::||.|..:|:|:|..||
  Fly    36 MEAPEFKDFAKTMVDFIAEYLENIRERRVLPEVKPGYLKPLIPDAAPEKPEKWQDVMQDIERVIM 100

  Fly    66 PGVTHWQHPRFHAYFPAGNSFPSILGDMLGDGIGCIGFSWAASPACTELETIVLDWLGKAIGLPD 130
            ||||||..|:||||||..||:|:|:.|||...|.||||:|.|||||||||.:::|||||.:.||.
  Fly   101 PGVTHWHSPKFHAYFPTANSYPAIVADMLSGAIACIGFTWIASPACTELEVVMMDWLGKMLELPA 165

  Fly   131 HFLALKEGSTGGGVIQTSASECVLVTMLAARAQALKRLKAQHPFVEEGHLLSKLMAYCSKEAHSC 195
            .|||. .|..||||||.:|||..||.:|.|:|:.||.:|..||..:|..:|.||:.|||.:|||.
  Fly   166 EFLAC-SGGKGGGVIQGTASESTLVALLGAKAKKLKEVKELHPEWDEHTILGKLVGYCSDQAHSS 229

  Fly   196 VEKAAMICFVKLRILEPDDDASLRGQTIYEAMEEDELQGLVPFFVSTTLGTTGSCAFDNLPEIGK 260
            ||:|.::..||||.:: .::..:||..:.:|:|:|..:||:||:...|||||.|||||.|.|.|.
  Fly   230 VERAGLLGGVKLRSVQ-SENHRMRGAALEKAIEQDVAEGLIPFYAVVTLGTTNSCAFDYLDECGP 293

  Fly   261 QLQRFPGVWLHVDAAYAGNSFICPELKPLLKGIEYADSFNTNPNKWLLTNFDCSTLWVRDRIRLT 325
            ...:. .:|:||||||||::|||||.:.|:||||.|||||.||:||:|.|||||.:|::|...:.
  Fly   294 VGNKH-NLWIHVDAAYAGSAFICPEYRHLMKGIESADSFNFNPHKWMLVNFDCSAMWLKDPSWVV 357

  Fly   326 SALVVDPLYLKHGYSDAAIDYRHWGVPLSRRFRSLKLWFVLRSYGISGLQHYIRHHIKLAKRFEE 390
            :|..||||||||....:|.|||||.:||.||||:||||||||.||:..||.:||.|...||:|.:
  Fly   358 NAFNVDPLYLKHDMQGSAPDYRHWQIPLGRRFRALKLWFVLRLYGVENLQAHIRRHCNFAKQFGD 422

  Fly   391 LVLKDKRFEICNQVKLGLVCFRLKGSDKLNEKLLSIINESGKLHMVPASVGDRYIIRFCAVAQNA 455
            |.:.|.|||:..::.:||||||||||::.||.||..||..|.:|:|||.:.|.|.:|....::..
  Fly   423 LCVADSRFELAAEINMGLVCFRLKGSNERNEALLKRINGRGHIHLVPAKIKDVYFLRMAICSRFT 487

  Fly   456 TAEDIDYAWDIIVDFANELLEKEQ 479
            .:||::|:|..:...|:| :|:||
  Fly   488 QSEDMEYSWKEVSAAADE-MEQEQ 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tdc2	NP_724489.1	Pyridoxal_deC	35..414	CDD:278699	206/378 (54%)
Ddc	NP_724163.1	Pyridoxal_deC	70..446	CDD:278699	206/378 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445349
Domainoid	1	1.000	368	1.000	Domainoid score	I180
eggNOG	1	0.900	-	-		E1_COG0076
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	417	1.000	Inparanoid score	I444
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D223497at33208
OrthoFinder	1	1.000	-	-		FOG0000865
OrthoInspector	1	1.000	-	-		mtm1068
orthoMCL	1	0.900	-	-		OOG6_100572
Panther	1	1.100	-	-	P	PTHR11999
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3838
SonicParanoid	1	1.000	-	-		X696
	12	11.830